Search Results - "Pugh, TD"

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging by Kujoth, G. C, Hiona, A, Pugh, T. D, Someya, S, Panzer, K, Wohlgemuth, S. E, Hofer, T, Seo, A. Y, Sullivan, R, Jobling, W. A, Morrow, J. D, Van Remmen, H, Sedivy, J. M, Yamasoba, T, Tanokura, M, Weindruch, R, Leeuwenburgh, C, Prolla, T. A

“…Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice…”
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Controlling caloric consumption: protocols for rodents and rhesus monkeys by Pugh, Thomas D, Klopp, Roger G, Weindruch, Richard

“…One approach for investigating biological aging is to compare control-fed animals with others restricted in calorie intake by 20% or more. Caloric restriction…”
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Dietary intervention at middle age : Caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice by PUGH, T. D, OBERLEY, T. D, WEINDRUCH, R

“…Dietary manipulations to prevent cancer and other diseases of aging have drawn broad public and scientific attention. One indicator of this interest is that…”
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Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart by Bronikowski, A. M, Carter, P. A, Morgan, T. J, Garland, T., Jr, Ung, N, Pugh, T. D, Weindruch, R, Prolla, T. A

“…1 Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011 2 School of Biological Sciences, Washington State University, Pullman, Washington…”
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In vivo Cytokine Gene Transfer by Gene Gun Reduces Tumor Growth in Mice by Sun, Wenn H., Burkholder, Joseph K., Sun, Jian, Culp, Jerilyn, Turner, Joel, Lu, Xing G., Pugh, Thomas D., Ershler, William B., Yang, Ning-Sun

“…Implantation of tumor cells modified by in vitro cytokine gene transfer has been shown by many investigators to result in potent in vivo antitumor activities…”
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Safety of interleukin-12 gene therapy against cancer: a murine biodistribution and toxicity study by Imboden, Michael, Shi, Fushun, Pugh, Thomas D, Freud, Aharon G, Thom, Nathaniel J, Hank, Jacquelin A, Hao, Zhengling, Staelin, Stephen T, Sondel, Paul M, Mahvi, David M

“…As a prerequisite for a human clinical trial using interleukin (IL)-12 gene therapy, the biodistribution and safety of IL-12, administered as an intradermal…”
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Orchiectomy increases bone marrow interleukin-6 levels in mice by Zhang, J, Pugh, T D, Stebler, B, Ershler, W B, Keller, E T

“…Interleukin-6 (IL-6) appears to be an important factor in disease states associated with bone resorption. There is both in vitro and in vivo evidence…”
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Influence of Fat Intake and Caloric Restriction on Bone in Aging Male Rats by Sanderson, Jeff P., Binkley, Neil, Roecker, Ellen B., Champ, Julia E., Pugh, Thomas D., Aspnes, Lauren, Weindruch, Richard

“…Caloric and fat intake may have important skeletal consequences. To evaluate this possibility, skeletal effects of adultonset caloric restriction (CR) at…”
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Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice by VOLK, M. J, PUGH, T. D, MOONJU KIM, FRITH, C. H, DAYNES, R. A, ERSHLER, W. B, WEINDRUCH, R

“…Dietary restriction (DR) started in middle age profoundly reduces the occurrence of lymphoma in C57BL/6 mice. Here, we report immunocellular and molecular…”
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Timed appearance of lymphocytic choriomeningitis virus after gastric inoculation of mice by Rai, SK, Micales, BK, Wu, MS, Cheung, DS, Pugh, TD, Lyons, GE, Salvato, MS

“…Arenaviruses present an emerging health threat in agrarian areas of Africa and South America; however, the natural routes of arenaviral infections are not…”
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In vivo particle-mediated cytokine gene transfer into canine oral mucosa and epidermis by Keller, E T, Burkholder, J K, Shi, F, Pugh, T D, McCabe, D, Malter, J S, MacEwen, E G, Yang, N S, Ershler, W B

“…Cytokines can stimulate immune effector cells present within the oral mucosa and epidermis to respond to vaccination or to combat cancer. However, intravenous…”
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Growth kinetics of microscopic hepatocellular neoplasms in carcinogen-resistant and carcinogen-responsive strains of mice by Pugh, T D, Goldfarb, S

“…The initiation and growth of microscopic hepatocellular neoplasms in C57BL/6 mice, considered relatively resistant to hepatocarcinogenesis, was compared with…”
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Prostatic localization of spontaneous early invasive carcinoma in Lobund-Wistar rats by PUGH, T. D, CHANG, C, UEMURA, H, WEINDRUCH, R

“…Animal models of human prostate cancer are very limited in number but are of obvious importance to develop. Dr. Morris Pollard (M. Pollard, J. Natl. Cancer…”
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Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital by Pugh, T D, Goldfarb, S

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Caloric restriction diminishes the age-associated loss of immunoreactive catalase in rat prostate by Suzuki, Kazuhiko, Oberley, Terry D., Pugh, Thomas D., Sempf, Joan M., Weindruch, Richard

“…BACKGROUND Caloric restriction (CR) retards aging and diseases in mice, rats, and other animals by unknown mechanisms. A popular hypothesis is that CR acts by…”
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Ovariectomy accelerates the growth of microscopic hepatocellular neoplasms in the mouse : possible association with whole body growth and fat deposition by GOLDFARB, S, PUGH, T. D

“…Ovariectomy (ovex) shortens the latency for development of hepatocellular neoplasms in mice, but the mechanism by which this occurs is not known. In the…”
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Reliable stereological method for estimating the number of microscopic hepatocellular foci from their transections by Pugh, T D, King, J H, Koen, H, Nychka, D, Chover, J, Wahba, G, He, Y H, Goldfarb, S

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Radon penetration of concrete slab cracks, joints, pipe penetrations, and sealants by Nielson, K K, Rogers, V C, Holt, R B, Pugh, T D, Grondzik, W A, de Meijer, R J

“…Radon movement through 12 test slabs with different cracks, pipe penetrations, cold joints, masonry blocks, sealants, and tensile stresses characterized the…”
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Neuropeptide Y- and peptide YY-containing colonic cells increase with ageing in male rats by Sweet, M.A, Ntambi, J.A, Gaumnitz, E.A, Pugh, T.D, Weindruch, R, Singaram, C

“…Colonic mucosal cells are known to contain several neuropeptides. The distribution of various peptidecontaining cells in the colon and their possible…”
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Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain's resistance to hepatocarcinogenesis by KAKIZOE, S, GOLDFARB, S, PUGH, T. D

“…C57BL/6 mice are relatively more resistant to hepatocarcinogens than C3H and C57BL/6 x C3H F1 (hereafter called B6C3F1) mice; however, the basis for this…”
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