Search Results - "Pugh, J."

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts by Roulois, David, Loo Yau, Helen, Singhania, Rajat, Wang, Yadong, Danesh, Arnavaz, Shen, Shu Yi, Han, Han, Liang, Gangning, Jones, Peter A., Pugh, Trevor J., O’Brien, Catherine, De Carvalho, Daniel D.

“…DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown mechanism of action. Using a combination of experimental and bioinformatics…”
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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy by Rehman, Sumaiyah K., Haynes, Jennifer, Collignon, Evelyne, Brown, Kevin R., Wang, Yadong, Nixon, Allison M.L., Bruce, Jeffrey P., Wintersinger, Jeffrey A., Singh Mer, Arvind, Lo, Edwyn B.L., Leung, Cherry, Lima-Fernandes, Evelyne, Pedley, Nicholas M., Soares, Fraser, McGibbon, Sophie, He, Housheng Hansen, Pollet, Aaron, Pugh, Trevor J., Haibe-Kains, Benjamin, Morris, Quaid, Ramalho-Santos, Miguel, Goyal, Sidhartha, Moffat, Jason, O’Brien, Catherine A.

“…Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that…”
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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity by Hezaveh, Kebria, Shinde, Rahul S, Klötgen, Andreas, Halaby, Marie Jo, Lamorte, Sara, Ciudad, M Teresa, Quevedo, Rene, Neufeld, Luke, Liu, Zhe Qi, Jin, Robbie, Grünwald, Barbara T, Foerster, Elisabeth G, Chaharlangi, Danica, Guo, Mengdi, Makhijani, Priya, Zhang, Xin, Pugh, Trevor J, Pinto, Devanand M, Co, Ileana L, McGuigan, Alison P, Jang, Gun Ho, Khokha, Rama, Ohashi, Pamela S, O'Kane, Grainne M, Gallinger, Steven, Navarre, William W, Maughan, Heather, Philpott, Dana J, Brooks, David G, McGaha, Tracy L

“…The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in…”
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Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling by Loganathan, Sampath K, Schleicher, Krista, Malik, Ahmad, Quevedo, Rene, Langille, Ellen, Teng, Katie, Oh, Robin H, Rathod, Bhavisha, Tsai, Ricky, Samavarchi-Tehrani, Payman, Pugh, Trevor J, Gingras, Anne-Claude, Schramek, Daniel

“…In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent…”
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Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial by Uppaluri, Ravindra, Campbell, Katie M, Egloff, Ann Marie, Zolkind, Paul, Skidmore, Zachary L, Nussenbaum, Brian, Paniello, Randal C, Rich, Jason T, Jackson, Ryan, Pipkorn, Patrik, Michel, Loren S, Ley, Jessica, Oppelt, Peter, Dunn, Gavin P, Barnell, Erica K, Spies, Nicholas C, Lin, Tianxiang, Li, Tiantian, Mulder, David T, Hanna, Youstina, Cirlan, Iulia, Pugh, Trevor J, Mudianto, Tenny, Riley, Rachel, Zhou, Liye, Jo, Vickie Y, Stachler, Matthew D, Hanna, Glenn J, Kass, Jason, Haddad, Robert, Schoenfeld, Jonathan D, Gjini, Evisa, Lako, Ana, Thorstad, Wade, Gay, Hiram A, Daly, Mackenzie, Rodig, Scott J, Hagemann, Ian S, Kallogjeri, Dorina, Piccirillo, Jay F, Chernock, Rebecca D, Griffith, Malachi, Griffith, Obi L, Adkins, Douglas R

“…Pembrolizumab improved survival in patients with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC). The aims of this study were to…”
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Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas by Seiwert, Tanguy Y, Zuo, Zhixiang, Keck, Michaela K, Khattri, Arun, Pedamallu, Chandra S, Stricker, Thomas, Brown, Christopher, Pugh, Trevor J, Stojanov, Petar, Cho, Juok, Lawrence, Michael S, Getz, Gad, Brägelmann, Johannes, DeBoer, Rebecca, Weichselbaum, Ralph R, Langerman, Alexander, Portugal, Louis, Blair, Elizabeth, Stenson, Kerstin, Lingen, Mark W, Cohen, Ezra E W, Vokes, Everett E, White, Kevin P, Hammerman, Peter S

“…The genetic differences between human papilloma virus (HPV)-positive and -negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To…”
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Landscape of genomic alterations in cervical carcinomas by Ojesina, Akinyemi I., Lichtenstein, Lee, Freeman, Samuel S., Pedamallu, Chandra Sekhar, Imaz-Rosshandler, Ivan, Pugh, Trevor J., Cherniack, Andrew D., Ambrogio, Lauren, Cibulskis, Kristian, Bertelsen, Bjørn, Romero-Cordoba, Sandra, Treviño, Victor, Vazquez-Santillan, Karla, Guadarrama, Alberto Salido, Wright, Alexi A., Rosenberg, Mara W., Duke, Fujiko, Kaplan, Bethany, Wang, Rui, Nickerson, Elizabeth, Walline, Heather M., Lawrence, Michael S., Stewart, Chip, Carter, Scott L., McKenna, Aaron, Rodriguez-Sanchez, Iram P., Espinosa-Castilla, Magali, Woie, Kathrine, Bjorge, Line, Wik, Elisabeth, Halle, Mari K., Hoivik, Erling A., Krakstad, Camilla, Gabiño, Nayeli Belem, Gómez-Macías, Gabriela Sofia, Valdez-Chapa, Lezmes D., Garza-Rodríguez, María Lourdes, Maytorena, German, Vazquez, Jorge, Rodea, Carlos, Cravioto, Adrian, Cortes, Maria L., Greulich, Heidi, Crum, Christopher P., Neuberg, Donna S., Hidalgo-Miranda, Alfredo, Escareno, Claudia Rangel, Akslen, Lars A., Carey, Thomas E., Vintermyr, Olav K., Gabriel, Stacey B., Barrera-Saldaña, Hugo A., Melendez-Zajgla, Jorge, Getz, Gad, Salvesen, Helga B., Meyerson, Matthew

“…Whole-exome sequencing and analysis of 115 cervical carcinoma–normal paired samples, in addition to transcriptome and whole-genome sequencing for a subset of…”
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Recurrent and functional regulatory mutations in breast cancer by Rheinbay, Esther, Parasuraman, Prasanna, Grimsby, Jonna, Tiao, Grace, Engreitz, Jesse M., Kim, Jaegil, Lawrence, Michael S., Taylor-Weiner, Amaro, Rodriguez-Cuevas, Sergio, Rosenberg, Mara, Hess, Julian, Stewart, Chip, Maruvka, Yosef E., Stojanov, Petar, Cortes, Maria L., Seepo, Sara, Cibulskis, Carrie, Tracy, Adam, Pugh, Trevor J., Lee, Jesse, Zheng, Zongli, Ellisen, Leif W., Iafrate, A. John, Boehm, Jesse S., Gabriel, Stacey B., Meyerson, Matthew, Golub, Todd R., Baselga, Jose, Hidalgo-Miranda, Alfredo, Shioda, Toshi, Bernards, Andre, Lander, Eric S., Getz, Gad

“…Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By…”
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Mutational heterogeneity in cancer and the search for new cancer-associated genes by Lawrence, Michael S., Stojanov, Petar, Polak, Paz, Kryukov, Gregory V., Cibulskis, Kristian, Sivachenko, Andrey, Carter, Scott L., Stewart, Chip, Mermel, Craig H., Roberts, Steven A., Kiezun, Adam, Hammerman, Peter S., McKenna, Aaron, Drier, Yotam, Zou, Lihua, Ramos, Alex H., Pugh, Trevor J., Stransky, Nicolas, Helman, Elena, Kim, Jaegil, Sougnez, Carrie, Ambrogio, Lauren, Nickerson, Elizabeth, Shefler, Erica, Cortés, Maria L., Auclair, Daniel, Saksena, Gordon, Voet, Douglas, Noble, Michael, DiCara, Daniel, Lin, Pei, Lichtenstein, Lee, Heiman, David I., Fennell, Timothy, Imielinski, Marcin, Hernandez, Bryan, Hodis, Eran, Baca, Sylvan, Dulak, Austin M., Lohr, Jens, Landau, Dan-Avi, Wu, Catherine J., Melendez-Zajgla, Jorge, Hidalgo-Miranda, Alfredo, Koren, Amnon, McCarroll, Steven A., Mora, Jaume, Lee, Ryan S., Crompton, Brian, Onofrio, Robert, Parkin, Melissa, Winckler, Wendy, Ardlie, Kristin, Gabriel, Stacey B., Roberts, Charles W. M., Biegel, Jaclyn A., Stegmaier, Kimberly, Bass, Adam J., Garraway, Levi A., Meyerson, Matthew, Golub, Todd R., Gordenin, Dmitry A., Sunyaev, Shamil, Lander, Eric S., Getz, Gad

“…As the sample size in cancer genome studies increases, the list of genes identified as significantly mutated is likely to include more false positives; here,…”
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Risk assessment tools in criminal justice and forensic psychiatry: The need for better data by Douglas, T, Pugh, J, Singh, I, Savulescu, J, Fazel, S

“…Abstract Violence risk assessment tools are increasingly used within criminal justice and forensic psychiatry, however there is little relevant, reliable and…”
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EVOLVE: A Multicenter Open-Label Single-Arm Clinical and Translational Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer after PARP Inhibition Progression by Lheureux, Stephanie, Oaknin, Ana, Garg, Swati, Bruce, Jeffrey P, Madariaga, Ainhoa, Dhani, Neesha C, Bowering, Valerie, White, Justin, Accardi, Sarah, Tan, Qian, Braunstein, Marsela, Karakasis, Katherine, Cirlan, Iulia, Pedersen, Stephanie, Li, Tiantiam, Fariñas-Madrid, Lorena, Lee, Yeh Chen, Liu, Zhihui Amy, Pugh, Trevor J, Oza, Amit M

“…PARP inhibitors (PARPi) are standard-of-care therapy for high-grade serous ovarian cancer (HGSOC). We investigated combining cediranib (antiangiogenic) with…”
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Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy by Lan, Xiaoyang, Jörg, David J., Cavalli, Florence M. G., Richards, Laura M., Nguyen, Long V., Vanner, Robert J., Guilhamon, Paul, Lee, Lilian, Kushida, Michelle M., Pellacani, Davide, Park, Nicole I., Coutinho, Fiona J., Whetstone, Heather, Selvadurai, Hayden J., Che, Clare, Luu, Betty, Carles, Annaick, Moksa, Michelle, Rastegar, Naghmeh, Head, Renee, Dolma, Sonam, Prinos, Panagiotis, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Arrowsmith, Cheryl H., Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Gallo, Marco, Lupien, Mathieu, Pugh, Trevor J., Taylor, Michael D., Hirst, Martin, Eaves, Connie J., Simons, Benjamin D., Dirks, Peter B.

“…Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity…”
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Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia by Mortensen, E. M, Pugh, M. J, Copeland, L. A, Restrepo, M. I, Cornell, J. E, Anzueto, A, Pugh, J. A

“…Recent studies suggest that statins and angiotensin-converting enzyme (ACE) inhibitors may have beneficial effects for some types of infections. The present…”
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Incidence of atrial fibrillation detected by implantable loop recorders in unexplained stroke by COTTER, Paul E, MARTIN, Peter J, RING, Liam, WARBURTON, Elizabeth A, BELHAM, Mark, PUGH, Peter J

“…The usefulness of the implantable loop recorder (ILR) with improved atrial fibrillation (AF) detection capability (Reveal XT) and the factors associated with…”
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Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation by Costello, Maura, Pugh, Trevor J, Fennell, Timothy J, Stewart, Chip, Lichtenstein, Lee, Meldrim, James C, Fostel, Jennifer L, Friedrich, Dennis C, Perrin, Danielle, Dionne, Danielle, Kim, Sharon, Gabriel, Stacey B, Lander, Eric S, Fisher, Sheila, Getz, Gad

“…As researchers begin probing deep coverage sequencing data for increasingly rare mutations and subclonal events, the fidelity of next generation sequencing…”
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Dissecting the genomic complexity underlying medulloblastoma by Jones, David T. W., Jäger, Natalie, Kool, Marcel, Zichner, Thomas, Hutter, Barbara, Sultan, Marc, Cho, Yoon-Jae, Pugh, Trevor J., Hovestadt, Volker, Stütz, Adrian M., Rausch, Tobias, Warnatz, Hans-Jörg, Ryzhova, Marina, Bender, Sebastian, Sturm, Dominik, Pleier, Sabrina, Cin, Huriye, Pfaff, Elke, Sieber, Laura, Wittmann, Andrea, Remke, Marc, Witt, Hendrik, Hutter, Sonja, Tzaridis, Theophilos, Weischenfeldt, Joachim, Raeder, Benjamin, Avci, Meryem, Amstislavskiy, Vyacheslav, Zapatka, Marc, Weber, Ursula D., Wang, Qi, Lasitschka, Bärbel, Bartholomae, Cynthia C., Schmidt, Manfred, von Kalle, Christof, Ast, Volker, Lawerenz, Chris, Eils, Jürgen, Kabbe, Rolf, Benes, Vladimir, van Sluis, Peter, Koster, Jan, Volckmann, Richard, Shih, David, Betts, Matthew J., Russell, Robert B., Coco, Simona, Paolo Tonini, Gian, Schüller, Ulrich, Hans, Volkmar, Graf, Norbert, Kim, Yoo-Jin, Monoranu, Camelia, Roggendorf, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Milde, Till, Kulozik, Andreas E., von Deimling, Andreas, Witt, Olaf, Maass, Eberhard, Rössler, Jochen, Ebinger, Martin, Schuhmann, Martin U., Frühwald, Michael C., Hasselblatt, Martin, Jabado, Nada, Rutkowski, Stefan, von Bueren, André O., Williamson, Dan, Clifford, Steven C., McCabe, Martin G., Peter Collins, V., Wolf, Stephan, Wiemann, Stefan, Lehrach, Hans, Brors, Benedikt, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Northcott, Paul A., Taylor, Michael D., Meyerson, Matthew, Pomeroy, Scott L., Yaspo, Marie-Laure, Korbel, Jan O., Korshunov, Andrey, Eils, Roland, Pfister, Stefan M., Lichter, Peter

“…Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging…”
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Randomized Trial of Hypofractionated, Dose-Escalated, Intensity-Modulated Radiation Therapy (IMRT) Versus Conventionally Fractionated IMRT for Localized Prostate Cancer by Hoffman, Karen E, Voong, K Ranh, Levy, Lawrence B, Allen, Pamela K, Choi, Seungtaek, Schlembach, Pamela J, Lee, Andrew K, McGuire, Sean E, Nguyen, Quynh, Pugh, Thomas J, Frank, Steven J, Kudchadker, Rajat J, Du, Weiliang, Kuban, Deborah A

“…Hypofractionated radiotherapy delivers larger daily doses of radiation and may increase the biologically effective dose delivered to the prostate. We conducted…”
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Polycystic Ovary Syndrome with Hyperandrogenism Is Characterized by an Increased Risk of Hepatic Steatosis Compared to Nonhyperandrogenic PCOS Phenotypes and Healthy Controls, Independent of Obesity and Insulin Resistance by Jones, Helen, Sprung, Victoria S, Pugh, Christopher J. A, Daousi, Christina, Irwin, Andrew, Aziz, Nabil, Adams, Valerie L, Thomas, E. Louise, Bell, Jimmy D, Kemp, Graham J, Cuthbertson, Daniel J

“…Context: Nonalcoholic fatty liver disease may be evident in women with polycystic ovary syndrome (PCOS), both conditions being associated with obesity and…”
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High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis by Greenaway, R. L., Santolini, V., Bennison, M. J., Alston, B. M., Pugh, C. J., Little, M. A., Miklitz, M., Eden-Rump, E. G. B., Clowes, R., Shakil, A., Cuthbertson, H. J., Armstrong, H., Briggs, M. E., Jelfs, K. E., Cooper, A. I.

“…Supramolecular synthesis is a powerful strategy for assembling complex molecules, but to do this by targeted design is challenging. This is because…”
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The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing by Pugh, Trevor J., Kelly, Melissa A., Gowrisankar, Sivakumar, Hynes, Elizabeth, Seidman, Michael A., Baxter, Samantha M., Bowser, Mark, Harrison, Bryan, Aaron, Daniel, Mahanta, Lisa M., Lakdawala, Neal K., McDermott, Gregory, White, Emily T., Rehm, Heidi L., Lebo, Matthew, Funke, Birgit H.

“…Purpose: Dilated cardiomyopathy is characterized by substantial locus, allelic, and clinical heterogeneity that necessitates testing of many genes across…”
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