Effects of a rehabilitation program on microvascular function of CHD patients assessed by near‐infrared spectroscopy

Effects of a rehabilitation program on microvascular function of CHD patients assessed by near‐infrared spectroscopy

This study aimed to evaluate whether near‐infrared spectroscopy (NIRS)‐derived reperfusion slope would detect the effects of a 12‐week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease (CHD). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 ...

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Bibliographic Details
Published in:Physiological reports Vol. 7; no. 11; pp. e14145 - n/a
Main Authors: Soares, Rogerio N., Murias, Juan M., Saccone, Flavia, Puga, Leopoldo, Moreno, Gustavo, Resnik, Miguel, De Roia, Gabriela F.
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01-06-2019
John Wiley and Sons Inc
Wiley
Subjects:
Blood pressure
Cardiovascular disease
Coronary artery disease
Exercise
Fitness training programs
Heart diseases
Heart rate
Infrared spectroscopy
Intervention
microvascular responsiveness
Microvasculature
NIRS
Occlusion
Original Research
Oxygenation
Patients
Physiology
Rehabilitation
Reperfusion
Shear stress
Spectrum analysis
Studies
vascular
Veins & arteries
NIRS
microvascular responsiveness
Cardiovascular disease
rehabilitation
vascular
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Summary:This study aimed to evaluate whether near‐infrared spectroscopy (NIRS)‐derived reperfusion slope would detect the effects of a 12‐week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease (CHD). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 years) underwent 12 weeks of drug treatment and high‐intensity interval training (HIIT), 2 times per week (40 min/session). Microvascular responsiveness was assessed by using NIRS assessment of muscle oxygen saturation (StO2) combined with a vascular occlusion test (VOT) (NIRS‐VOT). NIRS‐VOT measures were taken at pre‐ and postintervention, and microvascular responsiveness was evaluated by examining the slope 2 of re‐oxygenation rate (slope 2 StO2) and the area under the curve (StO2AUC) of StO2 signal following cuff release subsequent to a 5‐min occlusion period. The slope 2 StO2 was significantly steeper after 12 weeks of training (4.8 ± 1.6% sec−1) compared to the pretraining (3.1 ± 1.6% sec−1) (P < 0.05). The area under the curve for the change in the % StO2 signal during re‐oxygenation increased significantly from 3494 ± 2372%∙sec at pretraining to 9006 ± 4311%∙sec at post‐training (P < 0.05). NIRS‐VOT technique detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients. Coronary heart disease (CHD) is associated with vascular dysfunction at conduit and microvascular level. Near‐infrared spectroscopy detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients.
Bibliography:These authors contributed equally to this manuscript to share the last authorship.
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ISSN:2051-817X
DOI:10.14814/phy2.14145