Search Results - "Puerta, E"
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“Pdrugsapp”: A Mobil App for Implementing the Who Guide to Good Prescribing by Medical Students
Published in Clinical therapeutics (01-08-2017)Get full text
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Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers
Published in Psychopharmacology (01-10-2018)“…Rationale Antidepressant action has been linked to increased synaptic plasticity in which epigenetic mechanisms such as histone posttranslational acetylation…”
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geno5mC: A Database to Explore the Association between Genetic Variation (SNPs) and CpG Methylation in the Human Genome
Published in Journal of molecular biology (28-05-2021)“…[Display omitted] •DNA methylation and genetic variation was obtained from 58 WGBS datasets.•51,585 SNPs were found as statistically associated to CpG…”
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Sildenafil restores cognitive function without affecting β‐amyloid burden in a mouse model of Alzheimer's disease
Published in British journal of pharmacology (01-12-2011)“…BACKGROUND AND PURPOSE Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes…”
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SIRT2 inhibition reverses anhedonia in the VGLUT1+/− depression model
Published in Behavioural brain research (29-09-2017)“…Some histone deacetylase (HDACs) enzymes have been proposed as epigenetic targets involved in the pathophysiology of depression and antidepressant-like action…”
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Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex
Published in Pharmacology, biochemistry and behavior (01-08-2015)“…Many studies suggest that the prefrontal cortex (PFC) is a target limbic region for stress response because a dysfunction here is linked to anhedonia, a…”
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Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity
Published in European neuropsychopharmacology (01-11-2015)“…Abstract Changes in histone acetylation could contribute to the pathogenesis of depression and antidepressant therapy. Using the chronic social defeat stress…”
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Follicular progesterone concentrations and messenger RNA expression of MATER and OCT-4 in immature bovine oocytes as predictors of developmental competence
Published in Theriogenology (15-04-2015)“…The ability of bovine embryos to develop to the blastocyst stage and to implant and generate healthy offspring depends greatly on the competence of the oocyte…”
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Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma
Published in Surgical oncology (01-12-2020)“…ABCB1, DPYD, MHTFR, XRCC1, ERCC1, GSTP1 and UGT1A1 genetic variants affect proteins related to CRC chemotherapy toxicity. A retrospective cohort study was…”
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Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice
Published in Neuropharmacology (01-06-2015)“…Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that…”
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P.1.a.032 Beneficial effects of Sirtuin 2 inhibition in a mouse model of chronic stress
Published in European neuropsychopharmacology (01-09-2015)Get full text
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Satellite DNA methylation status and expression of selected genes in Bos indicus blastocysts produced in vivo and in vitro
Published in Zygote (Cambridge) (01-04-2017)“…Bovine embryos produced in vivo and in vitro differ with respect to molecular profiles, including epigenetic marks and gene expression profiles. This study…”
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P.2.a.024 Regulation of HDAC5 and Sirt2 by chronic stress and imipramine treatment in the prefrontal cortex
Published in European neuropsychopharmacology (01-10-2014)Get full text
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P.5.a.010 Sildenafil ameliorates cognitive deficits and APP amyloidogenic processing in a senescence-accelerated mouse model
Published in European neuropsychopharmacology (01-10-2014)Get full text
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P.1.g.108 Differential regulation of synaptic plasticity markers and behaviour by histone deacetylase inhibitors
Published in European neuropsychopharmacology (01-10-2014)Get full text
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On the mechanisms underlying 3,4-methylenedioxymethamphetamine toxicity: the dilemma of the chicken and the egg
Published in Neuropsychobiology (01-01-2009)“…Administration of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to various experimental animals has been shown to induce a selective damage to serotonergic…”
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PS1391 ASSESSMENT OF THE BURDEN OF DISEASE IN TERMS OF HEALTH‐RELATED QUALITY OF LIFE IN PATIENTS WITH MULTIPLE MYELOMA NOT ELIGIBLE FOR ASCT IN SPAIN: INTERIM ANALYSIS OF QOLMMBUS STUDY
Published in HemaSphere (01-06-2019)“…Background: Multiple myeloma (MM) is an incurable disease that is associated with severe symptoms affecting Health‐Related Quality of Life (HRQoL). Patients…”
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Theoretical generalization of normal and sick coronary arteries with fractal dimensions and the arterial intrinsic mathematical harmony
Published in BMC medical physics (17-09-2010)“…Fractal geometry is employ to characterize the irregular objects and had been used in experimental and clinic applications. Starting from a previous work, here…”
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