Search Results - "Puente Pérez, Pedro"
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d‐Amino acid substitutions and dimerization increase the biological activity and stability of an IL‐15 antagonist peptide
Published in Journal of peptide science (01-03-2021)“…Interleukin (IL)‐15 plays an important role in several inflammatory diseases. We have previously identified an IL‐15 antagonist called P8 peptide, which binds…”
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Antigen dose escalation study of a VEGF-based therapeutic cancer vaccine in non human primates
Published in Vaccine (05-01-2012)“…Highlights ► CIGB-247 is a cancer therapeutic, based on recombinant modified VEGF as antigen, in combination with powerful adjuvant VSSP. ► We extend the…”
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Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates
Published in Vaccine (26-04-2010)“…Abstract We have developed a cancer vaccine candidate (hereafter denominated CIGB-247), based on recombinant modified human vascular endothelial growth factor…”
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4
Experimental studies of a vaccine formulation of recombinant human VEGF antigen with aluminum phosphate
Published in Human vaccines & immunotherapeutics (03-08-2015)“…CIGB-247 is a cancer vaccine that is a formulation of a recombinant protein antigen representative of the human vascular endothelial growth factor (VEGF) with…”
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5
Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15
Published in BMC immunology (18-12-2021)“…Interleukin (IL)-15 is a proinflammatory T-cell growth factor overexpressed in several autoimmune diseases such as rheumatoid arthritis. Our initial strategy…”
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6
Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates
Published in BMC immunology (26-09-2016)“…Interleukin-15 is an immunostimulatory cytokine overexpressed in several autoimmune and inflammatory diseases such as Rheumatoid Arthritis, psoriasis and…”
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