Search Results - "Puduvalli, Vinay"

Tumor microenvironment in glioblastoma: Current and emerging concepts by Sharma, Pratibha, Aaroe, Ashley, Liang, Jiyong, Puduvalli, Vinay K

“…Abstract Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex system, which in addition to cancer cells, consists of various…”
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Demystifying demethylator sensitivity in gliomas: role for TERT and DNMT1 by Puduvalli, Vinay K

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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress by Cheng, Xiang, Geng, Feng, Pan, Meixia, Wu, Xiaoning, Zhong, Yaogang, Wang, Chunyan, Tian, Zhihua, Cheng, Chunming, Zhang, Rui, Puduvalli, Vinay, Horbinski, Craig, Mo, Xiaokui, Han, Xianlin, Chakravarti, Arnab, Guo, Deliang

“…Glioblastoma (GBM), a mostly lethal brain tumor, acquires large amounts of free fatty acids (FAs) to promote cell growth. But how the cancer avoids…”
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Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas by Wang, Joshua L, Barth, Rolf F, Cavaliere, Robert, Puduvalli, Vinay K, Giglio, Pierre, Lonser, Russell R, Elder, J Bradley

“…Carboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high…”
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Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial by Nassiri, Farshad, Patil, Vikas, Yefet, Leeor S., Singh, Olivia, Liu, Jeff, Dang, Rachel M. A., Yamaguchi, Takafumi N., Daras, Mariza, Cloughesy, Timothy F., Colman, Howard, Kumthekar, Priya U., Chen, Clark C., Aiken, Robert, Groves, Morris D., Ong, Shirley S., Ramakrishna, Rohan, Vogelbaum, Michael A., Khagi, Simon, Kaley, Thomas, Melear, Jason M., Peereboom, David M., Rodriguez, Analiz, Yankelevich, Maxim, Nair, Suresh G., Puduvalli, Vinay K., Aldape, Kenneth, Gao, Andrew, López-Janeiro, Álvaro, de Andrea, Carlos E., Alonso, Marta M., Boutros, Paul, Robbins, Joan, Mason, Warren P., Sonabend, Adam M., Stupp, Roger, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F., Zadeh, Gelareh

“…Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment approach for…”
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Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia by Sampath, Deepa, Liu, Chaomei, Vasan, Karthik, Sulda, Melanie, Puduvalli, Vinay K., Wierda, William G., Keating, Michael J.

“…Chronic lymphocytic leukemia (CLL) demonstrates a global down-regulation of miR-15a and miR-16 and a selective silencing of the related miR-29b in aggressive…”
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Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis by Geng, Feng, Cheng, Xiang, Wu, Xiaoning, Yoo, Ji Young, Cheng, Chunming, Guo, Jeffrey Yunhua, Mo, Xiaokui, Ru, Peng, Hurwitz, Brian, Kim, Sung-Hak, Otero, Jose, Puduvalli, Vinay, Lefai, Etienne, Ma, Jianjie, Nakano, Ichiro, Horbinski, Craig, Kaur, Balveen, Chakravarti, Arnab, Guo, Deliang

“…Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1), a transcription factor playing a central role in lipid metabolism, is…”
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Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma by WICK, Wolfgang, PUDUVALLI, Vinay K, LIEPA, Astra M, THORNTON, Donald E, FINE, Howard A, CHAMBERLAIN, Marc C, VAN DEN BENT, Martin J, CARPENTIER, Antoine F, CHER, Lawrence M, MASON, Warren, WELLER, Michael, SHENGYAN HONG, MUSIB, Luna

“…This phase III open-label study compared the efficacy and safety of enzastaurin versus lomustine in patients with recurrent glioblastoma (WHO grade 4)…”
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Protocol for real-time assessment of mitochondrial and glycolytic ATP production in patient-derived glioma stem-like cells by Sharma, Pratibha, Puduvalli, Vinay K.

“…Glioma cells switch between energetic pathways to adapt and resist therapies. We present a protocol for measuring mitochondrial and glycolytic ATP rates in…”
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Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study by Lassman, Andrew B, Sepúlveda-Sánchez, Juan Manuel, Cloughesy, Timothy F, Gil-Gil, Miguel J, Puduvalli, Vinay K, Raizer, Jeffrey J, De Vos, Filip Y F, Wen, Patrick Y, Butowski, Nicholas A, Clement, Paul M J, Groves, Morris D, Belda-Iniesta, Cristóbal, Giglio, Pierre, Soifer, Harris S, Rowsey, Steven, Xu, Cindy, Avogadri, Francesca, Wei, Ge, Moran, Susan, Roth, Patrick

“…FGFR genomic alterations (amplification, mutations, and/or fusions) occur in ∼8% of gliomas, particularly FGFR1 and FGFR3. We conducted a multicenter…”
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MGMT promoter methylation and survival following chemotherapy for WHO grade 4 IDH-mutant astrocytoma by Lim-Fat, Mary Jane, Wen, Patrick Y, Touat, Mehdi, Puduvalli, Vinay K, Iorgulescu, J Bryan

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Impact of provider level, training and gender on the utilization of palliative care and hospice in neuro-oncology: a North-American survey by Walbert, Tobias, Glantz, Michael, Schultz, Lonni, Puduvalli, Vinay K.

“…Specialized palliative care (PC) services have emerged to address symptoms and provide end-of-life management for patients with brain tumors. The utilization…”
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Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma by Brown, Aaron P., MD, Barney, Christian L., BS, Grosshans, David R., MD, PhD, McAleer, Mary Frances, MD, PhD, de Groot, John F., MD, Puduvalli, Vinay K., MD, Tucker, Susan L., PhD, Crawford, Cody N., CMD, Khan, Meena, CMD, Khatua, Soumen, MD, Gilbert, Mark R., MD, Brown, Paul D., MD, Mahajan, Anita, MD

“…Purpose Efficacy and acute toxicity of proton craniospinal irradiation (p-CSI) were compared with conventional photon CSI (x-CSI) for adults with…”
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Characterization of pseudoprogression in patients with glioblastoma: is histology the gold standard? by Melguizo-Gavilanes, Isaac, Bruner, Janet M., Guha-Thakurta, Nandita, Hess, Kenneth R., Puduvalli, Vinay K.

“…Pseudoprogression (psPD) refers to an increase in size or appearance of new areas of MRI contrast enhancement soon after completing chemoradiation, timely…”
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Triethylammonium Salts of Dicoumarol: Synthesis, Characterization, Human Antiglioblastoma, Antimicrobial and Antioxidant Studies by Rehman, Sadia, Ikram, Muhammad, Khan, Afzal, Khan, Adnan, Farzia, Khan, Rizwan, Sinnokrot, Mutasem Omar, Puduvalli, Vinay K, Jadoon, Ayub

“…The most typical primary brain tumor, glioblastoma multiforme (GBM), has a dismal prognosis. They are removed through arduous, potentially fatal operations…”
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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress by Sharma, Pratibha, Xu, Jihong, Williams, Katie, Easley, Michelle, Elder, J Brad, Lonser, Russell, Lang, Frederick F, Lapalombella, Rosa, Sampath, Deepa, Puduvalli, Vinay K

“…Abstract Background Tumor-specific metabolic processes essential for cell survival are promising targets to potentially circumvent intratumoral heterogeneity,…”
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A First-in-Human Phase I Study of BXQ-350, a First-in-Class Sphingolipid Metabolism Regulator, in Patients with Advanced/Recurrent Solid Tumors or High-Grade Gliomas by Rixe, Olivier, Villano, John L., Wesolowski, Robert, Noonan, Anne M., Puduvalli, Vinay K., Wise-Draper, Trisha M., Curry, Richard, Yilmaz, Emrullah, Cruze, Charlie, Ogretmen, Besim, Tapolsky, Gilles, Takigiku, Ray

“…Abstract Purpose: BXQ-350, a nanovesicle formulation of saposin C, is an allosteric sphingolipid metabolism regulator that increases proapoptotic ceramide and…”
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Multidisciplinary Management of Isocitrate Dehydrogenase-Mutated Gliomas in a Contemporary Molecularly Defined Era by Kotecha, Rupesh, Schiff, David, Chakravarti, Arnab, Fleming, Jessica L, Brown, Paul D, Puduvalli, Vinay K, Vogelbaum, Michael A, Gondi, Vinai, Gallus, Marco, Okada, Hideho, Mehta, Minesh P

“…Mutations in isocitrate dehydrogenase (IDH) genes, an early step in the ontogeny of lower-grade gliomas, induce global epigenetic changes characterized by a…”
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Phase 1 lead‐in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma by Maraka, Stefania, Groves, Morris D., Mammoser, Aaron G., Melguizo‐Gavilanes, Isaac, Conrad, Charles A., Tremont‐Lukats, Ivo W., Loghin, Monica E., O’Brien, Barbara J., Puduvalli, Vinay K., Sulman, Erik P., Hess, Kenneth R., Aldape, Kenneth D., Gilbert, Mark R., de Groot, John F., Alfred Yung, W.K., Penas‐Prado, Marta

“…Background Repurposed memantine, mefloquine, and metformin have putative anticancer activity. The objective of this phase 1 study was to determine the maximum…”
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NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022 by Horbinski, Craig, Nabors, Louis Burt, Portnow, Jana, Baehring, Joachim, Bhatia, Ankush, Bloch, Orin, Brem, Steven, Butowski, Nicholas, Cannon, Donald M, Chao, Samuel, Chheda, Milan G, Fabiano, Andrew J, Forsyth, Peter, Gigilio, Pierre, Hattangadi-Gluth, Jona, Holdhoff, Matthias, Junck, Larry, Kaley, Thomas, Merrell, Ryan, Mrugala, Maciej M, Nagpal, Seema, Nedzi, Lucien A, Nevel, Kathryn, Nghiemphu, Phioanh L, Parney, Ian, Patel, Toral R, Peters, Katherine, Puduvalli, Vinay K, Rockhill, Jason, Rusthoven, Chad, Shonka, Nicole, Swinnen, Lode J, Weiss, Stephanie, Wen, Patrick Yung, Willmarth, Nicole E, Bergman, Mary Anne, Darlow, Susan

“…The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2-3…”
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