Search Results - "Puduvalli, V"

Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation by Gopisetty, G, Xu, J, Sampath, D, Colman, H, Puduvalli, V K

“…Tumor stem cells, postulated to be the source cells for malignancies, have been identified in several cancers using cell-surface expression of markers…”
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A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma by Kesanakurti, D, Maddirela, D, Banasavadi-Siddegowda, Y K, Lai, T-H, Qamri, Z, Jacob, N K, Sampath, D, Mohanam, S, Kaur, B, Puduvalli, V K

“…Tumor recurrence in glioblastoma (GBM) is, in part, attributed to increased epithelial-to-mesenchymal transition (EMT) and enhanced tumor cell dissemination in…”
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A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients by Raizer, J. J., Giglio, P., Hu, J., Groves, M., Merrell, R., Conrad, C., Phuphanich, S., Puduvalli, V. K., Loghin, M., Paleologos, N., Yuan, Y., Liu, D., Rademaker, A., Yung, W. K., Vaillant, B., Rudnick, J., Chamberlain, M., Vick, N., Grimm, S., Tremont-Lukats, I. W., De Groot, J., Aldape, K., Gilbert, M. R.

“…Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ)…”
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Two phase II trials of temozolomide with interferon-α2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme by Groves, M D, Puduvalli, V K, Gilbert, M R, Levin, V A, Conrad, C A, Liu, V H, Hunter, K, Meyers, C, Hess, K R, Alfred Yung, W K

“…Background: Because of the poor outcomes for patients with recurrent glioblastoma multiforme (GBM), and some laboratory and clinical evidence of efficacy using…”
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Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma by de Groot, J. F., Gilbert, M. R., Aldape, K., Hess, K. R., Hanna, T. A., Ictech, S., Groves, M. D., Conrad, C., Colman, H., Puduvalli, V. K., Levin, V., Yung, W. K. A.

“…Targeting the epidermal growth factor receptor (EGFR) may be effective in a subset of glioblastoma patients. This phase II study assessed the clinical activity…”
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TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation by Puduvalli, V K, Sampath, D, Bruner, J M, Nangia, J, Xu, R, Kyritsis, A P

“…Patients with malignant gliomas have a poor prognosis and new treatment paradigms are needed against this disease. TRAIL/Apo2L selectively induces apoptosis in…”
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Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts by Liu, Y, Lang, F, Xie, X, Prabhu, S, Xu, J, Sampath, D, Aldape, K, Fuller, G, Puduvalli, V K

“…Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells, including gliomas, and is currently in…”
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Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment of glioblastoma multiforme by LEVIN, V. A, GIGLIO, P, PUDUVALLI, V. K, JOCHEC, J, GROVES, M. D, YUNG, W. K. A, HESS, K

“…In a phase II clinical trial, we sought to determine if combining celecoxib with 13-cis-retinoic acid (13-cRA, Accutane) was efficacious in the treatment of…”
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Antiangiogenesis -- therapeutic strategies and clinical implications for brain tumors by Puduvalli, V K, Sawaya, R

“…The poor prognosis of patients with malignant brain tumors in spite of aggressive multimodality therapy has led to the search for novel therapeutic strategies…”
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Radio-responsive TRAIL gene therapy for malignant gliomas by Kyritsis, A P, Rao, J S, Puduvalli, V K

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Brain metastases: biology and the role of the brain microenvironment by Puduvalli, V K

“…Metastatic lesions constitute the most frequently occurring malignancy in the brain, and their detection portends a grim prognosis. Efforts to treat these…”
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A phase I study of temozolomide (TMZ) and the farnesyltransferase inhibitor (FTI), lonafarnib (Sarazar, SCH66336) in recurrent glioblastoma by Gilbert, M. R., Gaupp, P., Liu, V., Conrad, C., Colman, H., Groves, M., Puduvalli, V., Levin, V., Hsu, S., Horowitz, J., Yung, W.

“…Abstract only 1556 Background: Farnesylation is essential for the post-translational modification of several proteins that play a role in cell proliferation…”
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Fenretinide Activates Caspases and Induces Apoptosis in Gliomas by Puduvalli, V K, Saito, Y, Xu, R, Kouraklis, G P, Levin, V A, Kyritsis, A P

“…The synthetic retinoid fenretinide ( N -[4-hydroxyphenyl] retinamide or 4HPR) has been shown to not only inhibit cell growth but also to induce apoptosis in a…”
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Patterns of expression of Rb and p16 in astrocytic gliomas, and correlation with survival by Puduvalli, V K, Kyritsis, A P, Hess, K R, Bondy, M L, Fuller, G N, Kouraklis, G P, Levin, V A, Bruner, J M

“…The retinoblastoma pathway is a key cell cycle regulatory complex that controls the passage of cells through the G1 checkpoint and is a frequent target of…”
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249 ORAL Specific activation of microRNA 106b targets the ubiquitin ligase ITCH to enable the p73 apoptotic response in chronic lymphocytic leukemia by Sampath, D, Calin, G.A, Puduvalli, V, Gopisetty, G, Taccioli, C, Liu, C.G, Ewald, B, Liu, C, Keating, M.J, Plunkett, W

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Induction of apoptosis by N-(4-hydroxyphenyl)retinamide in glioma cells by Saitoh, Y, Goto, T, Puduvalli, V K, Murakami, M, Kochi, M, Levin, V A, Kyritsis, A P, Ushio, Y

“…N-(4-hydroxyphenyl)retinamide (fenretinide) is a synthetic retinoid with anticancer properties. We investigated the effects of fenretinide on the growth of…”
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Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: implications for therapy by Fueyo, J, Gomez-Manzano, C, Puduvalli, V K, Martin-Duque, P, Perez-Soler, R, Levin, V A, Yung, W K, Kyritsis, A P

“…Malignant gliomas are highly resistant to chemotherapy, in part because of the blood-brain barrier, which restricts the delivery of chemotherapy to certain…”
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JS01.5.A PHASE 2 TRIAL OF CARBOPLATIN AND BEVACIZUMAB FOR RECURRENT ADULT EPENDYMOMA. A CERN STUDY by Gilbert, M R, Omuro, A, Yuan, Y, Mendoza, T, Wall, K, Grajkowska, E, Vera, E, Reyes, J, Aldape, K, Penas-Prado, M, Walbert, T, Mikkelsen, T, Weathers, S, O'Brien, B, DeGroot, J, Puduvalli, V, Pentsova, E, DeAngelis, L, Kaley, T, Gavrilovic, I, Batchelor, T, Armstrong, T S

“…Abstract BACKGROUND Most adults with ependymoma undergo tumor resection at the time of diagnosis, which may be followed by radiation. At recurrence,…”
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A novel interaction of PAK4 with PPAR[gamma] to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma by Kesanaku, Maddirela, D, Banasavadi-Siddegowda, Y K, Lai, T-H, Qamri, Z, Jacob, N K, Sampath, D, Mohanam, S, Kaur, B, Puduvalli, V K

“…Tumor recurrence in glioblastoma (GBM) is, in part, attributed to increased epithelial-to-mesenchymal transition (EMT) and enhanced tumor cell dissemination in…”
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Phase I Study of Trametinib in Combination with Whole-Brain Radiation Therapy for Brain Metastases by Fabian, D., Wuthrick, E.J., Wei, L., Tan, J., Grecula, J.C., Welliver, M.X., Williams, T.M., Elder, J.B., Raval, R., Blakaj, D.M., Haglund, K.E., Bazan, J.G., Kendra, K.L., Liebner, D., Puduvalli, V., Giglio, P., Gonzalez, J., Arnett, A.L.H., Bell, E.H., Chakravarti, A., Palmer, J.D.

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