Search Results - "Puddicombe, Sarah M."

Defective epithelial barrier function in asthma by Xiao, Chang, PhD, Puddicombe, Sarah M., PhD, Field, Sarah, PhD, Haywood, Joel, BSc, Broughton-Head, Victoria, PhD, Puxeddu, Ilaria, MD, PhD, Haitchi, Hans Michael, MD, PhD, Vernon-Wilson, Elizabeth, PhD, Sammut, David, MD, Bedke, Nicole, PhD, Cremin, Catherine, BSc, Sones, Jody, BSc, Djukanović, Ratko, MD, DM, Howarth, Peter H., MD, DM, Collins, Jane E., PhD, Holgate, Stephen T., MD, DSc, Monk, Phillip, PhD, Davies, Donna E., PhD

“…Background Asthma is a complex disease involving gene and environment interactions. Although atopy is a strong predisposing risk factor for asthma, local…”
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Asthmatic Bronchial Epithelium Is More Susceptible to Oxidant-Induced Apoptosis by Bucchieri, Fabio, Puddicombe, Sarah M, Lordan, James L, Richter, Audrey, Buchanan, Diane, Wilson, Susan J, Ward, Jon, Zummo, Giovanni, Howarth, Peter H, Djukanovic, Ratko, Holgate, Stephen T, Davies, Donna E

“…Abnormal apoptotic mechanisms are associated with disease pathogenesis. Because the asthmatic bronchial epithelium is characteristically damaged with loss of…”
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The Contribution of Interleukin (IL)-4 and IL-13 to the Epithelial-Mesenchymal Trophic Unit in Asthma by Richter, Audrey, Puddicombe, Sarah M, Lordan, James L, Bucchieri, Fabio, Wilson, Susan J, Djukanovic', Ratko, Dent, Gordon, Holgate, Stephen T, Davies, Donna E

“…Interleukin (IL)-4 and IL-13 are key proinflammatory cytokines in asthma. Studies in transgenic mice show that both cytokines cause inflammation, but only…”
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Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells by Lordan, James L, Bucchieri, Fabio, Richter, Audrey, Konstantinidis, Athanassias, Holloway, John W, Thornber, Matthew, Puddicombe, Sarah M, Buchanan, Diana, Wilson, Susan J, Djukanovic, Ratko, Holgate, Stephen T, Davies, Donna E

“…In sensitized individuals, exposure to allergens such as Dermatophagoides pteronyssinus (Der p) causes Th2 polarization and release of cytokines, including…”
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Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium by Mullings, Rebecca E., Wilson, Susan J., Puddicombe, Sarah M., Lordan, James L., Bucchieri, Fabio, Djukanović, Ratko, Howarth, Peter H., Harper, Steven, Holgate, Stephen T., Davies, Donna E.

“…Background: Asthma is associated with increased production of IL-4 and IL-13. Objective: Because many of the effects of these cytokines are mediated by…”
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Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects by Polosa, Riccardo, Puddicombe, Sarah M., Krishna, M.Thirumala, Tuck, Angela B., Howarth, Peter H., Holgate, Stephen T., Davies, Donna E.

“…Background: The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to regulate cell behavior. Disturbances in this system have been…”
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Kinetic Analysis of the Interleukin-13 Receptor Complex by Andrews, Allison-Lynn, Holloway, John W, Puddicombe, Sarah M, Holgate, Stephen T, Davies, Donna E

“…Interleukin (IL)-13 is a key cytokine associated with the asthmatic phenotype. It signals via its cognate receptor, a complex of IL-13 receptor α1 chain…”
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Airway remodeling in asthma: New insights by Nelson, Harold S., Davies, Donna E., Wicks, James, Powell, Robert M., Puddicombe, Sarah M., Holgate, Stephen T.

“…Continuing Medical Education examination CONTINUING MEDICAL EDUCATION ARTICLECredit can now be obtained, free for a limited time, by reading the following…”
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Characterization of Ciliated Bronchial Epithelium 1, a Ciliated Cell-Associated Gene Induced During Mucociliary Differentiation by Yoshisue, Hajime, Puddicombe, Sarah M, Wilson, Susan J, Haitchi, Hans Michael, Powell, Robert M, Wilson, David I, Pandit, Anita, Berger, Ann E, Davies, Donna E, Holgate, Stephen T, Holloway, John W

“…Lung epithelial structure is altered in asthma; however, the precise mechanisms underlying epithelial repair, including differentiation from basal to columnar…”
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Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma by Holgate, S T, Lackie, P M, Howarth, P H, Roche, W R, Puddicombe, S M, Richter, A, Wilson, S J, Holloway, J W, Davies, D E

“…A recent NIH Workshop and an ERS Task Force concluded that more work was needed to understand mechanisms of severe and chronic asthma. This report describes a…”
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Epithelial-mesenchymal interactions in the pathogenesis of asthma by Holgate, Stephen T., Davies, Donna E., Lackie, Peter M., Wilson, Susan J., Puddicombe, Sarah M., Lordan, James L.

“…During lung development, repair, and inflammation, local production of cytokines (eg, transforming growth factor-β) and growth factors (eg, epidermal growth…”
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Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles by Parnia, Sam, Hamilton, Lynnsey M, Puddicombe, Sarah M, Holgate, Stephen T, Frew, Anthony J, Davies, Donna E

“…Diesel exhaust is associated with cardiovascular and respiratory mortality and morbidity. Acute exposure leads to increased IL-8 expression and airway…”
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Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma by Babu, Suresh K, Puddicombe, Sarah M, Arshad, Hasan H, Wilson, Susan J, Ward, John, Gozzard, Neil, Higgs, Gerry, Holgate, Stephen T, Davies, Donna E

“…Abstract Subjects with mild asthma underwent repeated low-dose allergen exposure and bronchial biopsies were examined for the expression of TNF-α and adhesion…”
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Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium by Puddicombe, Sarah M, Torres-Lozano, Carlos, Richter, Audrey, Bucchieri, Fabio, Lordan, James L, Howarth, Peter H, Vrugt, Bart, Albers, Rene, Djukanovic, Ratko, Holgate, Stephen T, Wilson, Susan J, Davies, Donna E

“…Because the asthmatic bronchial epithelium is characterized by widespread damage, we postulated that this is associated with expression of cell cycle…”
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Structure−Function Studies of Ligand-Induced Epidermal Growth Factor Receptor Dimerization by Neelam, Beena, Richter, Audrey, Chamberlin, Stephen G, Puddicombe, Sarah M, Wood, Lynn, Murray, Mary Beth, Nandagopal, Krishnadas, Niyogi, Salil K, Davies, Donna E

“…We present a novel 96-well assay which we have applied to a structure−function study of epidermal growth factor receptor dimerization. The basis of the assay…”
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β-Catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells by Steel, Mark D., Puddicombe, Sarah M., Hamilton, Lynnsey M., Powell, Rob M., Holloway, John W., Holgate, Stephen T., Davies, Donna E., Collins, Jane E.

“…The embryonic Wnt/β-catenin (‘canonical’) pathway has been implicated in epithelial regeneration. To investigate the role of Wnt signal transduction in the…”
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Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue by Knapper, J M, Puddicombe, S M, Morgan, L M, Fletcher, J M

“…The direct actions of glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1(7-36)amide and insulin on lipoprotein lipase activity in explants…”
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Increased Expression of p21waf Cyclin-Dependent Kinase Inhibitor in Asthmatic Bronchial Epithelium by Puddicombe, Sarah M, Torres-Lozano, Carlos, Richter, Audrey, Bucchieri, Fabio, Lordan, James L, Howarth, Peter H, Vrugt, Bart, Albers, Rene, Djukanovic, Ratko, Holgate, Stephen T, Wilson, Susan J, Davies, Donna E

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Increased Expression of p21 waf Cyclin-Dependent Kinase Inhibitor in Asthmatic Bronchial Epithelium by Puddicombe, Sarah M., Torres-Lozano, Carlos, Richter, Audrey, Bucchieri, Fabio, Lordan, James L., Howarth, Peter H., Vrugt, Bart, Albers, Rene, Djukanovic, Ratko, Holgate, Stephen T., Wilson, Susan J., Davies, Donna E.

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The Interaction of an Epidermal Growth Factor/Transforming Growth Factor α Tail Chimera with the Human Epidermal Growth Factor Receptor Reveals Unexpected Complexities by Sarah M. Puddicombe, Lynn Wood, Stephen G. Chamberlin, Donna E. Davies

“…It has been assumed that substitution of homologous regions of transforming growth factor α (TGF-α) into epidermal growth factor (EGF) can be used to probe…”
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