Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis?

Sphingosine 1-phosphate (S1P) has recently been reported to induce antimycobacterial activity in vitro and in a mouse model of in vivo Mycobacterium tuberculosis infection. However, its role in the course of pulmonary tuberculosis in humans is still not known. This study shows that S1P levels in air...

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Bibliographic Details
Published in:	Clinical Immunology Vol. 121; no. 3; pp. 260 - 264
Main Authors:	Garg, Sanjay K., Santucci, Marilina B., Panitti, Miriam, Pucillo, Leo, Bocchino, Marialuisa, Okajima, Fumikazu, Bisen, Prakash S., Saltini, Cesare, Fraziano, Maurizio
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-12-2006 Elsevier
Subjects:	Adult Animals Biological and medical sciences Bronchoalveolar lavage Cells, Cultured Cricetinae Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Immunotherapy Lysophospholipids - metabolism Lysophospholipids - pharmacology Male Medical sciences Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology Sphingosine 1-phosphate Tuberculosis Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Tuberculosis Bronchoalveolar lavage Immunotherapy Sphingosine 1-phosphate Immunopathology Lung disease Respiratory disease Pulmonary tuberculosis Mycobacterial infection Infection Prevention Immunology Treatment Bacteriosis
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Summary:	Sphingosine 1-phosphate (S1P) has recently been reported to induce antimycobacterial activity in vitro and in a mouse model of in vivo Mycobacterium tuberculosis infection. However, its role in the course of pulmonary tuberculosis in humans is still not known. This study shows that S1P levels in airway surface fluid of tuberculosis (TB) patients are significantly less than those observed in non-TB control patients. Moreover, the in vitro stimulation of bronchoalveolar lavage cells coming from TB patients with S1P significantly reduces intracellular growth of endogenous mycobacterial isolates. These results show that, in the course of pulmonary TB, airway epithelial fluid-associated S1P may play a protective role in the containment of intracellular mycobacterial growth and that its decrease may represent a novel pathogenic mechanism through which M. tuberculosis favors its replication.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1521-6616 1521-7035 1365-2567
DOI:	10.1016/j.clim.2006.09.002