Search Results - "Puchowicz"

Effect of statin treatment on metabolites, lipids and prostanoids in patients with Statin Associated Muscle Symptoms (SAMS) by Garrett, Timothy J, Puchowicz, Michelle A, Park, Edwards A, Dong, Qingming, Farage, Gregory, Childress, Richard, Guingab, Joy, Simpson, Claire L, Sen, Saunak, Brogdon, Elizabeth C, Buchanan, Logan M, Raghow, Rajendra, Elam, Marshall B

“…Between 5-10% of patients discontinue statin therapy due to statin-associated adverse reactions, primarily statin associated muscle symptoms (SAMS). The…”
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HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism by Du, Weinan, Zhang, Luchang, Brett-Morris, Adina, Aguila, Brittany, Kerner, Janos, Hoppel, Charles L., Puchowicz, Michelle, Serra, Dolors, Herrero, Laura, Rini, Brian I., Campbell, Steven, Welford, Scott M.

“…Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor…”
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Murine deficiency of peroxisomal l-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis by Ranea-Robles, Pablo, Violante, Sara, Argmann, Carmen, Dodatko, Tetyana, Bhattacharya, Dipankar, Chen, Hongjie, Yu, Chunli, Friedman, Scott L., Puchowicz, Michelle, Houten, Sander M.

“…Peroxisomes play an essential role in the β-oxidation of dicarboxylic acids (DCAs), which are metabolites formed upon ω-oxidation of fatty acids. Genetic…”
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Ketosis Proportionately Spares Glucose Utilization in Brain by Zhang, Yifan, Kuang, Youzhi, Xu, Kui, Harris, Donald, Lee, Zhenghong, LaManna, Joseph, Puchowicz, Michelle A

“…The brain is dependent on glucose as a primary energy substrate, but is capable of utilizing ketones such as β-hydroxybutyrate and acetoacetate, as occurs with…”
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Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof by McDonald, Tanya, Puchowicz, Michelle, Borges, Karin

“…There is mounting evidence that oxidative glucose metabolism is impaired in epilepsy and recent work has further characterized the metabolic mechanisms…”
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Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain by Sethuraman, Aarti, Rao, Prahlad, Pranay, Atul, Xu, Kui, LaManna, Joseph, Puchowicz, Michelle A

“…Hypoxia inducible factor alpha (HIF1α) is associated with neuroprotection conferred by diet-induced ketosis but the underlying mechanism remains unclear. In…”
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Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise by Mera, Paula, Laue, Kathrin, Ferron, Mathieu, Confavreux, Cyril, Wei, Jianwen, Galán-Díez, Marta, Lacampagne, Alain, Mitchell, Sarah J., Mattison, Julie A., Chen, Yun, Bacchetta, Justine, Szulc, Pawel, Kitsis, Richard N., de Cabo, Rafael, Friedman, Richard A., Torsitano, Christopher, McGraw, Timothy E., Puchowicz, Michelle, Kurland, Irwin, Karsenty, Gerard

“…Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time levels of insulin decrease. In contrast,…”
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Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue by Stephenson, Erin J., Stayton, Amanda S., Sethuraman, Aarti, Rao, Prahlad K., Meyer, Alice, Gomes, Charles Klazer, Mulcahy, Molly C., McAllan, Liam, Puchowicz, Michelle A., Pierre, Joseph F., Bridges, Dave, Han, Joan C.

“…Almost all effective treatments for non-alcoholic fatty liver disease (NAFLD) involve reduction of adiposity, which suggests the metabolic axis between liver…”
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Intranasal Delivery of Mitochondria Attenuates Brain Injury by AMPK and SIRT1/PGC-1α Pathways in a Murine Model of Photothrombotic Stroke by Salman, Mohd, Stayton, Amanda S, Parveen, Kehkashan, Parveen, Arshi, Puchowicz, Michelle A, Parvez, Suhel, Bajwa, Amandeep, Ishrat, Tauheed

“…Ischemic stroke is one of the major causes of morbidity and mortality worldwide. Mitochondria play a vital role in the pathological processes of cerebral…”
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Development and field validation of an omni-domain power-duration model by Puchowicz, Michael J., Baker, Jonathan, Clarke, David C.

“…Purpose: To validate and compare a novel model based on the critical power (CP) concept that describes the entire domain of maximal mean power (MMP) data from…”
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Decreased carbon shunting from glucose toward oxidative metabolism in diet‐induced ketotic rat brain by Zhang, Yifan, Zhang, Shenghui, Marin‐Valencia, Isaac, Puchowicz, Michelle A.

“…The mechanistic link of ketosis to neuroprotection under certain pathological conditions continues to be explored. We investigated whether chronic ketosis…”
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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance by KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L

“…We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase…”
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Myeloid Slc2a1 -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1 by Freemerman, Alex J, Zhao, Liyang, Pingili, Ajeeth K, Teng, Bin, Cozzo, Alyssa J, Fuller, Ashley M, Johnson, Amy R, Milner, J Justin, Lim, Maili F, Galanko, Joseph A, Beck, Melinda A, Bear, James E, Rotty, Jeremy D, Bezavada, Lavanya, Smallwood, Heather S, Puchowicz, Michelle A, Liu, Juan, Locasale, Jason W, Lee, Douglas P, Bennett, Brian J, Abel, E Dale, Rathmell, Jeff C, Makowski, Liza

“…Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory…”
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Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism by Frederick, David W., Davis, James G., Dávila, Antonio, Agarwal, Beamon, Michan, Shaday, Puchowicz, Michelle A., Nakamaru-Ogiso, Eiko, Baur, Joseph A.

“…The NAD biosynthetic precursors nicotinamide mononucleotide and nicotinamide riboside are reported to confer resistance to metabolic defects induced by high…”
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Surface-enhanced Raman spectroscopy (SERS) in cotton fabrics analysis by Puchowicz, Dorota, Giesz, Patrycja, Kozanecki, Marcin, Cieślak, Małgorzata

“…This article presents some aspects of application the dispersive Micro- Raman Spectroscopy in textile fibers analysis. Research were dedicated to the…”
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Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain by Sethuraman, Aarti, Rao, Prahlad, Pranay, Atul, Xu, Kui, LaManna, Joseph C, Puchowicz, Michelle A

“…Hypoxia inducible factor alpha (HIF1α) is associated with neuroprotection conferred by diet-induced ketosis, but the underlying mechanism remains unclear. In…”
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Overcompensation of CoA Trapping by Di(2-ethylhexyl) Phthalate (DEHP) Metabolites in Livers of Wistar Rats by Hala, David, Petersen, Lene H, Huggett, Duane B, Puchowicz, Michelle A, Brunengraber, Henri, Zhang, Guo-Fang

“…Di(2-ethylhexyl) phthalate (DEHP) is commonly used as a plasticizer in various industrial and household plastic products, ensuring widespread human exposures…”
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Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype by Ko, Chih-Wei, Counihan, Daniel, Wu, Jing, Hatzoglou, Maria, Puchowicz, Michelle A., Croniger, Colleen M.

“…Phosphoenolpyruvate carboxykinase (Pck1) is a metabolic enzyme that is integral to the gluconeogenic and glyceroneogenic pathways. However, Pck1's role in…”
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Neuroprotection in diet-induced ketotic rat brain after focal ischemia by Puchowicz, Michelle A, Zechel, Jennifer L, Valerio, Jose, Emancipator, Douglas S, Xu, Kui, Pundik, Svetlana, LaManna, Joseph C, Lust, W David

“…Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible factor (HIF)-1α, a primary constituent associated with hypoxic…”
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Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer by Babcook, Melissa A, Shukla, Sanjeev, Fu, Pingfu, Vazquez, Edwin J, Puchowicz, Michelle A, Molter, Joseph P, Oak, Christine Z, MacLennan, Gregory T, Flask, Chris A, Lindner, Daniel J, Parker, Yvonne, Daneshgari, Firouz, Gupta, Sanjay

“…Docetaxel chemotherapy remains a standard of care for metastatic castration-resistant prostate cancer (CRPC). Docetaxel modestly increases survival, yet…”
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