Search Results - "Puchkova, Ludmila"

Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis by Polishchuk, Elena V., Merolla, Assunta, Lichtmannegger, Josef, Romano, Alessia, Indrieri, Alessia, Ilyechova, Ekaterina Y., Concilli, Mafalda, De Cegli, Rossella, Crispino, Roberta, Mariniello, Marta, Petruzzelli, Raffaella, Ranucci, Giusy, Iorio, Raffaele, Pietrocola, Federico, Einer, Claudia, Borchard, Sabine, Zibert, Andree, Schmidt, Hartmut H., Di Schiavi, Elia, Puchkova, Ludmila V., Franco, Brunella, Kroemer, Guido, Zischka, Hans, Polishchuk, Roman S.

“…Wilson disease (WD) is an inherited disorder of copper metabolism that leads to copper accumulation and toxicity in the liver and brain. It is caused by…”
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Chemical background of silver nanoparticles interfering with mammalian copper metabolism by Skvortsov, Alexey N., Ilyechova, Ekaterina Yu, Puchkova, Ludmila V.

“…The rapidly increasing application of silver nanoparticles (AgNPs) boosts their release into the environment, which raises a reasonable alarm for ecologists…”
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The Features of Copper Metabolism in the Rat Liver during Development by Zatulovskaia, Yulia A, Ilyechova, Ekaterina Y, Puchkova, Ludmila V

“…Strong interest in copper homeostasis is due to the fact that copper is simultaneously a catalytic co-factor of the vital enzymes, a participant in signaling,…”
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A low blood copper concentration is a co-morbidity burden factor in Parkinson’s disease development by Ilyechova, Ekaterina Y., Miliukhina, Irina V., Orlov, Iurii A., Muruzheva, Zamira M., Puchkova, Ludmila V., Karpenko, Marina N.

“…Parkinson’s disease (PD) patients are often characterized by copper dyshomeostasis, which is responsible for ROS formation and fibrillogenesis. However, the…”
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Silver Ions as a Tool for Understanding Different Aspects of Copper Metabolism by Puchkova, Ludmila V, Broggini, Massimo, Polishchuk, Elena V, Ilyechova, Ekaterina Y, Polishchuk, Roman S

“…In humans, copper is an important micronutrient because it is a cofactor of ubiquitous and brain-specific cuproenzymes, as well as a secondary messenger…”
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The Crossroads between Host Copper Metabolism and Influenza Infection by Puchkova, Ludmila V., Kiseleva, Irina V., Polishchuk, Elena V., Broggini, Massimo, Ilyechova, Ekaterina Yu

“…Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral…”
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Copper Metabolism of Newborns Is Adapted to Milk Ceruloplasmin as a Nutritive Source of Copper: Overview of the Current Data by Puchkova, Ludmila V, Babich, Polina S, Zatulovskaia, Yulia A, Ilyechova, Ekaterina Y, Di Sole, Francesca

“…Copper, which can potentially be a highly toxic agent, is an essential nutrient due to its role as a cofactor for cuproenzymes and its participation in…”
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The role of subcutaneous adipose tissue in supporting the copper balance in rats with a chronic deficiency in holo-ceruloplasmin by Ilyechova, Ekaterina Y, Tsymbalenko, Nadezhda V, Puchkova, Ludmila V

“…We have previously shown that (1) an acute deficiency in blood serum holo-ceruloplasmin (Cp) developed in rats that were fed fodder containing silver ions…”
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Biogenetic and morphofunctional heterogeneity of mitochondria: the case of synaptic mitochondria by Fedorovich, Sergei V, Waseem, Tatyana V, Puchkova, Ludmila V

“…The mitochondria of different cells are different in their morphological and biochemical properties. These organelles generate free radicals during activity,…”
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Properties of recombinant extracellular N-terminal domain of human high-affinity copper transporter 1 (hNdCTR1) and its interactions with Cu(II) and Ag(I) ions by Orlov, Iurii A, Sankova, Tatiana P, Skvortsov, Alexey N, Klotchenko, Sergey A, Sakhenberg, Elena I, Mekhova, Aleksandra A, Kiseleva, Irina V, Ilyechova, Ekaterina Yu, Puchkova, Ludmila V

“…High-affinity copper transporter 1 (CTR1) is a key link in the transfer of copper (Cu) from the extracellular environment to the cell. Violation in the control…”
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The Effect of Mice Adaptation Process on the Pathogenicity of Influenza A/South Africa/3626/2013 (H1N1)pdm09 Model Strain by Al Farroukh, Mohammad, Kiseleva, Irina, Stepanova, Ekaterina, Bazhenova, Ekaterina, Krutikova, Elena, Tkachev, Artem, Chistyakova, Anna, Rekstin, Andrey, Puchkova, Ludmila, Rudenko, Larisa

“…Influenza virus strain A/South Africa/3626/2013 (H1N1)pdm09 (SA-WT) is a non-mouse-adapted model strain that has naturally high pathogenic properties in mice…”
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A new Caenorhabditis elegans model to study copper toxicity in Wilson disease by Catalano, Federico, O'Brien, Thomas J., Mekhova, Aleksandra A., Sepe, Lucia Vittoria, Elia, Mariantonietta, De Cegli, Rossella, Gallotta, Ivan, Santonicola, Pamela, Zampi, Giuseppina, Ilyechova, Ekaterina Y., Romanov, Aleksei A., Samuseva, Polina D., Salzano, Josephine, Petruzzelli, Raffaella, Polishchuk, Elena V., Indrieri, Alessia, Kim, Byung‐Eun, Brown, André E. X., Puchkova, Ludmila V., Di Schiavi, Elia, Polishchuk, Roman S.

“…Wilson disease (WD) is caused by mutations in the ATP7B gene that encodes a copper (Cu) transporting ATPase whose trafficking from the Golgi to endo‐lysosomal…”
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CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences by Ilyechova, Ekaterina Y, Bonaldi, Elisa, Orlov, Iurii A, Skomorokhova, Ekaterina A, Puchkova, Ludmila V, Broggini, Massimo

“…Copper, the highly toxic micronutrient, plays two essential roles: it is a catalytic and structural cofactor for Cu-dependent enzymes, and it acts as a…”
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Understanding the Variability of Certain Biological Properties of H1N1pdm09 Influenza Viruses by Al Farroukh, Mohammad, Kiseleva, Irina, Bazhenova, Ekaterina, Stepanova, Ekaterina, Puchkova, Ludmila, Rudenko, Larisa

“…The influenza virus continually evolves because of the high mutation rate, resulting in dramatic changes in its pathogenicity and other biological properties…”
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Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover by Skomorokhova, Ekaterina A, Sankova, Tatiana P, Orlov, Iurii A, Savelev, Andrew N, Magazenkova, Daria N, Pliss, Mikhail G, Skvortsov, Alexey N, Sosnin, Ilya M, Kirilenko, Demid A, Grishchuk, Ivan V, Sakhenberg, Elena I, Polishchuk, Elena V, Brunkov, Pavel N, Romanov, Alexey E, Puchkova, Ludmila V, Ilyechova, Ekaterina Yu

“…The ability of silver nanoparticles (AgNPs) of different sizes to influence copper metabolism in mice is assessed. AgNPs with diameters of 10, 20, and 75 nm…”
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Abnormalities in Copper Status Associated with an Elevated Risk of Parkinson’s Phenotype Development by Karpenko, Marina N., Muruzheva, Zamira M., Ilyechova, Ekaterina Yu, Babich, Polina S., Puchkova, Ludmila V.

“…In the last 15 years, among the many reasons given for the development of idiopathic forms of Parkinson’s disease (PD), copper imbalance has been identified as…”
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Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin by Mariniello, Marta, Petruzzelli, Raffaella, Wanderlingh, Luca G, La Montagna, Raffaele, Carissimo, Annamaria, Pane, Francesca, Amoresano, Angela, Ilyechova, Ekaterina Y, Galagudza, Michael M, Catalano, Federico, Crispino, Roberta, Puchkova, Ludmila V, Medina, Diego L, Polishchuk, Roman S

“…Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent…”
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Non-Mouse-Adapted H1N1pdm09 Virus as a Model for Influenza Research by Kiseleva, Irina, Rekstin, Andrey, Al Farroukh, Mohammad, Bazhenova, Ekaterina, Katelnikova, Anastasia, Puchkova, Ludmila, Rudenko, Larisa

“…The number of lung-adapted influenza viruses is limited. Most of them are not antigenically related to current circulating viruses. Viruses similar to recent…”
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Influence of Silver Nanoparticles on the Growth of Ascitic and Solid Ehrlich Adenocarcinoma: Focus on Copper Metabolism by Magazenkova, Daria N, Skomorokhova, Ekaterina A, Farroukh, Mohammad Al, Zharkova, Maria S, Jassem, Zena M, Rekina, Valeria E, Shamova, Olga V, Puchkova, Ludmila V, Ilyechova, Ekaterina Y

“…The link between copper metabolism and tumor progression motivated us to use copper chelators for suppression of tumor growth. We assume that silver…”
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In vivo effect of copper status on cisplatin-induced nephrotoxicity by Puchkova, Ludmila V., Skvortsov, Alexey N., Rusconi, Paolo, Ilyechova, Ekaterina Yu, Broggini, Massimo

“…Cisplatin is a widely used antitumor agent; however, tumor resistance and severe side effects limit its use. It is well accepted that cisplatin toxicity can be…”
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