Search Results - "Pucci, Bruna"

SIRT5 regulation of ammonia-induced autophagy and mitophagy by Polletta, Lucia, Vernucci, Enza, Carnevale, Ilaria, Arcangeli, Tania, Rotili, Dante, Palmerio, Silvia, Steegborn, Clemens, Nowak, Theresa, Schutkowski, Mike, Pellegrini, Laura, Sansone, Luigi, Villanova, Lidia, Runci, Alessandra, Pucci, Bruna, Morgante, Emanuela, Fini, Massimo, Mai, Antonello, Russo, Matteo A, Tafani, Marco

“…In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is…”
Get full text

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction by Marfe, Gabriella, Tafani, Marco, Indelicato, Manuela, Sinibaldi-Salimei, Paola, Reali, Valentina, Pucci, Bruna, Fini, Massimo, Russo, Matteo Antonio

“…Kaempferol (3,4′,5,7‐tetrahydroxyflavone) is a flavonoid with anti‐ and pro‐oxidant activity present in various natural sources. Kaempferol has been shown to…”
Get full text

Cell Cycle and Apoptosis by Pucci, Bruna, Kasten, Margaret, Giordano, Antonio

“…In multicellular organisms, cell proliferation and death must be regulated to maintain tissue homeostasis. Many observations suggest that this regulation may…”
Get full text

Role of hypoxia and autophagy in MDA-MB-231 invasiveness by Indelicato, Manuela, Pucci, Bruna, Schito, Luana, Reali, Valentina, Aventaggiato, Michele, Mazzarino, Maria C., Stivala, Franca, Fini, Massimo, Russo, Matteo A., Tafani, Marco

“…Survival strategies adopted by tumor cells in response to a hypoxic stress include activation of hypoxia‐inducible factor 1 (HIF‐1) and autophagy. However, the…”
Get full text

Activation of MyoD-dependent transcription by cdk9/cyclin T2 by Simone, Cristiano, Stiegler, Peter, Bagella, Luigi, Pucci, Bruna, Bellan, Cristiana, De Falco, Giulia, De Luca, Antonio, Guanti, Ginevra, Puri, Pier Lorenzo, Giordano, Antonio

“…Myogenic transcription is repressed in myoblasts by serum-activated cyclin-dependent kinases, such as cdk2 and cdk4. Serum withdrawal promotes muscle-specific…”
Get full text

Induction of autophagic cell death by a novel molecule Is increased by hypoxia by Tafani, Marco, Schito, Luana, Anwar, Tahira, Indelicato, Manuela, Sale, Patrizio, Di Vito, Maura, Morgante, Emanuela, Beraldi, Rosanna, Makovec, Francesco, Letari, Ornella, Caselli, Gianfranco, Spadafora, Corrado, Pucci, Bruna, Russo, Matteo A.

“…Adaptation to hypoxia through activation of the hypoxia inducible factor-1 (HIF-1) is crucial for tumor cells survival. Here we describe the antitumoral…”
Get full text

The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners by Marfe, Gabriella, Tafani, Marco, Pucci, Bruna, Di Stefano, Carla, Indelicato, Manuela, Andreoli, Angela, Russo, Matteo Antonio, Sinibaldi-Salimei, Paola, Manzi, Vincenzo

“…A large body of evidence shows that a single bout of strenuous exercise induces oxidative stress in circulating human lymphocytes leading to lipid…”
Get full text

Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF by Pucci, Bruna, Bertani, Francesca, Karpinich, Natalie O., Indelicato, Manuela, Russo, Matteo A., Farber, John L., Tafani, Marco

“…Induction of cell death in HeLa cells with TNF and cycloheximide (CHX) required an adequate ATP supply and was accompanied by decrease in intracellular pH,…”
Get full text

Aspirin Extrusion From Human Platelets Through Multidrug Resistance Protein-4–Mediated Transport by Mattiello, Teresa, DPharm, Guerriero, Raffaella, PhD, Lotti, Lavinia Vittoria, PhD, Trifirò, Elisabetta, PhD, Felli, Maria Pia, PhD, Barbarulo, Alessandro, PhD, Pucci, Bruna, PhD, Gazzaniga, Paola, MD, Gaudio, Carlo, MD, Frati, Luigi, MD, Pulcinelli, Fabio M., MD

“…Objectives In this study we investigate: 1) the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating…”
Get full text

Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation by Pucci, Bruna, Adams, Christopher S., Fertala, Jolanta, Snyder, Bradley C., Mansfield, Kyle D., Tafani, Marco, Freeman, Theresa, Shapiro, Irving M.

“…The maturation of epiphyseal chondrocytes is accompanied by dramatic changes in energy metabolism and shifts in proteins concerned with the induction of…”
Get full text

Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2 by Carlberg, Alyssa L., Pucci, Bruna, Rallapalli, Ravikumar, Tuan, Rocky S., Hall, David J.

“…The multipotential murine embryonic C3H10T1/2 mesenchymal cell line is able to undergo chondrogenesis in vitro, in a high density micromass environment,…”
Get full text

Insulin-like growth factor-1 inhibits STS-induced cell death and increases functional recovery of in vitro differentiated neurons by Pucci, Bruna, Bertani, Francesca, Indelicato, Manuela, Sale, Patrizio, Lococo, Emanuela, Grassi, Francesca, Pagani, Francesca, Colafrancesco, Valeria, Morgante, Emanuela, Tafani, Marco, Fini, Massimo, Russo, Matteo A.

“…NG108-15 cells differentiate into neurons by 1 mM sodium butyrate (NaB) treatment. Differentiated cells resulted more resistant to staurosporine (STS) than…”
Get full text

pRb2/p130 Promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation by PUCCI, Bruna, CLAUDIO, Pier Paolo, MASCIULLO, Valeria, BELLINCAMPI, Lorenza, TERRINONI, Alessandro, KHALILI, Kamel, MELINO, Gerry, GIORDANO, Antonio

“…This study shows that in the glioblastoma hamster cell line HJC12 the retinoblastoma family member pRb2/p130 enhances gamma-radiation-induced cell death. In…”
Get full text

Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB by Tafani, Marco, Schito, Luana, Pellegrini, Laura, Villanova, Lidia, Marfe, Gabriella, Anwar, Tahira, Rosa, Roberta, Indelicato, Manuela, Fini, Massimo, Pucci, Bruna, Russo, Matteo A.

“…The role of hypoxia in regulating tumor progression is still controversial. Here, we demonstrate that, similarly to what previously observed by us in human…”
Get full text

A Transcriptionally Inactive E2F-1 Targets the MDM Family of Proteins for Proteolytic Degradation by Strachan, Gordon D., Rallapalli, Ravikumar, Pucci, Bruna, Lafond, Toulouse P., Hall, David J.

“…E2F-1-activated transcription promotes cell cycle progression and apoptosis. These functions are regulated by several factors including the E2F-1-binding…”
Get full text

Role of the Dopaminergic System in the Development of Myopia in Children and Adolescents by Nebbioso, Marcella, Plateroti, Andrea Maria, Pucci, Bruna, Pescosolido, Nicola

“…This review summarizes the experimental evidence that supports the role of dopamine in the regulation of ocular axial growth. The most important functions…”
Get full text

Association of dietary flavan-3-ol intakes with plasma phenyl-γ-valerolactones: analysis from the TUDA cohort of healthy older adults by Angelino, Donato, Caffrey, Aoife, McNulty, Helene, Gill, Chris IR, Mena, Pedro, Rosi, Alice, Moore, Katie, Hoey, Leane, Clements, Michelle, Laird, Eamon, Boyd, Kerrie, Mullen, Brian, Pucci, Bruna, Jarrett, Harry, Cunningham, Conal, Ward, Mary, Strain, J.J., McCarroll, Kevin, Moore, Adrian J., Molloy, Anne M., Del Rio, Daniele

“…Dietary polyphenols, including flavan-3-ols (F3O), are associated with better health outcomes. The relationship of plasma phenyl-γ-valerolactones (PVLs), the…”
Get full text

SIRT1 silencing confers neuroprotection through IGF-1 pathway activation by Sansone, Luigi, Reali, Valentina, Pellegrini, Laura, Villanova, Lidia, Aventaggiato, Michele, Marfe, Gabriella, Rosa, Roberta, Nebbioso, Marcella, Tafani, Marco, Fini, Massimo, Russo, Matteo A., Pucci, Bruna

“…The following study demonstrated that, in in vitro differentiated neurons, SIRT1 silencing induced an increase of IGF‐1 protein expression and secretion and of…”
Get full text

Aspirin Extrusion From Human Platelets Through Multidrug Resistance Protein-4―Mediated Transport: Evidence of a Reduced Drug Action in Patients After Coronary Artery Bypass Grafting by MATTIELLO, Teresa, GUERRIERO, Raffaella, PULCINELLI, Fabio M, VITTORIA LOTTI, Lavinia, TRIFIRO, Elisabetta, PIA FELLI, Maria, BARBARULO, Alessandro, PUCCI, Bruna, GAZZANIGA, Paola, GAUDIO, Carlo, FRATI, Luigi

“…In this study we investigate: 1) the role of multidrug resistance protein-4 (MRP4), an organic anion unidirectional transporter, in modulating aspirin action…”
Get full text

Modulators of HIF1α and NFkB in Cancer Treatment: Is it a Rational Approach for Controlling Malignant Progression? by Tafani, Marco, Pucci, Bruna, Russo, Andrea, Schito, Luana, Pellegrini, Laura, Perrone, Giulietta A, Villanova, Lidia, Salvatori, Luisa, Ravenna, Linda, Petrangeli, Elisa, Russo, Matteo A

“…HIF1α and NFkB are two transcription factors very frequently activated in tumors and involved in tumor growth, progression, and resistance to chemotherapy. In…”
Get full text