Search Results - "Pürstinger, Gerhard"

Identification of 2‑(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus by Moesslacher, Julia, Battisti, Verena, Delang, Leen, Neyts, Johan, Abdelnabi, Rana, Pürstinger, Gerhard, Urban, Ernst, Langer, Thierry

“…The chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus, and it is the causative agent of chikungunya fever (CHIKF). Although it has re-emerged as…”
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The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family by van der Linden, Lonneke, Vives-Adrián, Laia, Selisko, Barbara, Ferrer-Orta, Cristina, Liu, Xinran, Lanke, Kjerstin, Ulferts, Rachel, De Palma, Armando M, Tanchis, Federica, Goris, Nesya, Lefebvre, David, De Clercq, Kris, Leyssen, Pieter, Lacroix, Céline, Pürstinger, Gerhard, Coutard, Bruno, Canard, Bruno, Boehr, David D, Arnold, Jamie J, Cameron, Craig E, Verdaguer, Nuria, Neyts, Johan, van Kuppeveld, Frank J M

“…The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71)…”
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Quinolinecarboxamides Inhibit the Replication of the Bovine Viral Diarrhea Virus by Targeting a Hot Spot for the Inhibition of Pestivirus Replication in the RNA-Dependent RNA Polymerase by Musiu, Simone, Castillo, Yunierkis Perez, Muigg, Alexandra, Pürstinger, Gerhard, Leyssen, Pieter, Froeyen, Mathy, Neyts, Johan, Paeshuyse, Jan

“…The bovine viral diarrhea virus (BVDV), a pestivirus from the family of is ubiquitous and causes a range of clinical manifestations in livestock, mainly…”
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The Thiazolobenzimidazole TBZE-029 Inhibits Enterovirus Replication by Targeting a Short Region Immediately Downstream from Motif C in the Nonstructural Protein 2C by De Palma, Armando M, Heggermont, Ward, Lanke, Kjerstin, Coutard, Bruno, Bergmann, Mirko, Monforte, Anna-Maria, Canard, Bruno, De Clercq, Erik, Chimirri, Alba, Pürstinger, Gerhard, Rohayem, Jacques, van Kuppeveld, Frank, Neyts, Johan

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Mechanistic Characterization of GS-9190 (Tegobuvir), a Novel Nonnucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase by Shih, I-Hung, Vliegen, Inge, Peng, Betty, Yang, Huiling, Hebner, Christy, Paeshuyse, Jan, Pürstinger, Gerhard, Fenaux, Martijn, Tian, Yang, Mabery, Eric, Qi, Xiaoping, Bahador, Gina, Paulson, Matthew, Lehman, Laura S, Bondy, Steven, Tse, Winston, Reiser, Hans, Lee, William A, Schmitz, Uli, Neyts, Johan, Zhong, Weidong

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Allosteric Regulation of Phosphatidylinositol 4‑Kinase III Beta by an Antipicornavirus Compound MDL-860 by Arita, Minetaro, Dobrikov, Georgi, Pürstinger, Gerhard, Galabov, Angel S

“…MDL-860 is a broad-spectrum antipicornavirus compound discovered in 1982 and one of the few promising candidates effective in in vivo virus infection. Despite…”
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Potential use of antiviral agents in polio eradication by De Palma, Armando M, Pürstinger, Gerhard, Wimmer, Eva, Patick, Amy K, Andries, Koen, Rombaut, Bart, De Clercq, Erik, Neyts, Johan

“…In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to…”
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Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice by Stoyanova, Adelina, Nikolova, Ivanka, Pürstinger, Gerhard, Dobrikov, Georgi, Dimitrov, Vladimir, Philipov, Stefan, Galabov, Angel S

“…Background Chemotherapy is an important tool for controlling enterovirus infections, but clinically effective anti-enterovirus drugs do not currently exist,…”
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Synthesis, Cytotoxic, and Antitumor Activities of 2-Pyridylhydrazones Derived from 3-Benzoylpyridazines by Easmon, Johnny, Pürstinger, Gerhard, Heinisch, Gottfried, Fiebig, Hans H., Roth, Thomas, Hofmann, Johann

“…A series of 2‐pyridylhydrazones derived from phenyl‐pyridazin‐3‐yl‐methanones were prepared in search for potential novel antitumor agents. The stereochemistry…”
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Synthesis, Structure−Activity Relationships, and Antitumor Studies of 2-Benzoxazolyl Hydrazones Derived from Alpha-(N)-acyl Heteroaromatics by Easmon, Johnny, Pürstinger, Gerhard, Thies, Katrin-Sofia, Heinisch, Gottfried, Hofmann, Johann

“…Recently we have described the antitumor activities of 2-benzoxazolylhydrazones derived from 2-formyl and 2-acetylpyridines. In search of a more efficacious…”
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Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles by Pürstinger, Gerhard, De Palma, Armando M., Zimmerhofer, Günther, Huber, Simone, Ladurner, Sophie, Neyts, Johan

“…The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in…”
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Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication by van der Schaar, Hilde M, van der Linden, Lonneke, Lanke, Kjerstin H W, Strating, Jeroen R P M, Pürstinger, Gerhard, de Vries, Erik, de Haan, Cornelis A M, Neyts, Johan, van Kuppeveld, Frank J M

“…RNA viruses can rapidly mutate and acquire resistance to drugs that directly target viral enzymes, which poses serious problems in a clinical context…”
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Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines by EASMON, Johnny, PüRSTINGER, Gerhard, HEINISCH, Gottfried, ROTH, Thomas, FIEBIG, Heinz H., HOLZER, Wolfgang, JäGER, Walter, JENNY, Marcel, HOFMANN, Johann

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Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors by Kovacikova, Kristina, Gorostiola González, Marina, Jones, Rhian, Reguera, Juan, Gigante, Alba, Pérez-Pérez, María-Jesús, Pürstinger, Gerhard, Moesslacher, Julia, Langer, Thierry, Jeong, Lak Shin, Delang, Leen, Neyts, Johan, Snijder, Eric J, van Westen, Gerard J P, van Hemert, Martijn J

“…Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) harbors the methyltransferase (MTase) and guanylyltransferase (GTase) activities needed for viral RNA…”
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Substituted 2,6-bis(benzimidazol-2-yl)pyridines: A novel chemical class of pestivirus inhibitors that targets a hot spot for inhibition of pestivirus replication in the RNA-dependent RNA polymerase by Musiu, Simone, Pürstinger, Gerhard, Stallinger, Sylvia, Vrancken, Robert, Haegeman, Andy, Koenen, Frank, Leyssen, Pieter, Froeyen, Mathy, Neyts, Johan, Paeshuyse, Jan

“…•BBP is a selective inhibitor of BVDV and CSFV replication.•Resistant viruses carry mutation I261M for BVDV or I261N/P262A for CSFV in the RdRp.•BBP-resistant…”
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Foreign Direct Investments and Mergers and Acquisitions in Slovakia by Pürstinger, Gerhard, Soltés, Vincent

“…The paper gives answer why Slovakia is so attractive for Foreign Direct Investments. There are discussed economics factors in Slovakia and there are compared…”
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Substituted imidazopyridines as potent inhibitors of HCV replication by Vliegen, Inge, Paeshuyse, Jan, De Burghgraeve, Tine, Lehman, Laura S, Paulson, Matthew, Shih, I-Hung, Mabery, Eric, Boddeker, Nina, De Clercq, Erik, Reiser, Hans, Oare, David, Lee, William A, Zhong, Weidong, Bondy, Steven, Pürstinger, Gerhard, Neyts, Johan

“…Background/Aims Following lead optimization, a set of substituted imidazopyridines was identified as potent and selective inhibitors of in vitro HCV…”
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H1PVAT is a novel and potent early-stage inhibitor of poliovirus replication that targets VP1 by TIJSMA, Aloys, THIBAUT, Hendrik Jan, MARCHAND, Arnaud, CHALTIN, Patrick, NEYTS, Johan, LEYSSEN, Pieter, SPIESER, Stéphane A. H, DE PALMA, Armando, KOUKNI, Mohamed, RHODEN, Eric, OBERSTE, Steve, PÜRSTINGER, Gerhard, VOLNY-LURAGHI, Antonia, MARTIN, Javier

“…A novel small molecule, H1PVAT, was identified as a potent and selective inhibitor of the in vitro replication of all three poliovirus serotypes, whereas no…”
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The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family by van Der Linden, Lonneke, Vives-Adrián, Laia, Selisko, Barbara, Ferrer-Orta, Cristina, Liu, Xinran, Lanke, Kjerstin, Ulferts, Rachel, de Palma, Armando M., Tanchis, Federica, Goris, Nesya, Lefebvre, David, de Clercq, Kris, Leyssen, Pieter, Lacroix, Céline, Pürstinger, Gerhard, Coutard, Bruno, Canard, Bruno, Boehr, David D., Arnold, Jamie J., Cameron, Craig E., Verdaguer, Nuria, Neyts, Johan, van Kuppeveld, Frank J. M

“…The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71)…”
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The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family: e1004733 by Linden, Lonneke vander, Vives-Adrián, Laia, Selisko, Barbara, Ferrer-Orta, Cristina, Liu, Xinran, Lanke, Kjerstin, Ulferts, Rachel, Palma, Armando MDe, Tanchis, Federica, Goris, Nesya, Lefebvre, David, Clercq, Kris De, Leyssen, Pieter, Lacroix, Céline, Pürstinger, Gerhard, Coutard, Bruno, Canard, Bruno, Boehr, David D, Arnold, Jamie J, Cameron, Craig E, Verdaguer, Nuria, Neyts, Johan, Kuppeveld, J Mvan

“…The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71)…”
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