Search Results - "Pu, Xiaohui"

The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer by Chang, Sheng, Yang, Qiang, Liu, Jiahuan, Yin, Li, Han, Jihong, Zong, Lanlan, Pu, Xiaohui

“…The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral…”
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Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis by Zhou, Yunfeng, Wang, Chunli, Kou, Jiejian, Wang, Minghui, Rong, Xuli, Pu, Xiaohui, Xie, Xinmei, Han, Guang, Pang, Xiaobin

“…Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Bianliang ziyu, a variety of Chrysanthemum morifolium Ramat. (Asteraceae), has…”
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Redox-Responsive Disulfide Bond-Bridged mPEG-PBLA Prodrug Micelles for Enhanced Paclitaxel Biosafety and Antitumor Efficacy by Chang, Sheng, Wang, Yanfei, Zhang, Tianyi, Pu, Xiaohui, Zong, Lanlan, Zhu, Heyun, Zhao, Luling, Feng, Bo

“…The toxicity and side effects of traditional chemotherapeutic drugs are the main causes of chemotherapy failure. To improve the specificity and selectivity of…”
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Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects by Qiao, Yonghui, Wei, Zhihao, Qin, Tingting, Song, Rufeng, Yu, Zhiqiang, Yuan, Qi, Du, Juan, Zeng, Qingbing, Zong, Lanlan, Duan, Shaofeng, Pu, Xiaohui

“…In this paper, a new nanosuspensions, hydroxycamptothecin (HCPT) and quercetin (QUR) hybrid nanosuspensions (HQ-NPs), was constructed by intermolecular force…”
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Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing by Zong, Lanlan, Teng, Runxin, Zhang, Huiqi, Liu, Wenshang, Feng, Yu, Lu, Zhengmao, Zhou, Yuxiao, Fan, Zhen, Li, Meng, Pu, Xiaohui

“…Despite advancements in therapeutic agents for diabetic chronic wounds, challenges such as suboptimal bioavailability, intricate disease milieus, and…”
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Development of a chemically stable 10-hydroxycamptothecin nanosuspensions by Pu, Xiaohui, Sun, Jin, Wang, Yan, Wang, Yongjun, Liu, Xiaohong, Zhang, Peng, Tang, Xing, Pan, Weisan, Han, Jihong, He, Zhonggui

“…The purpose of this study was to prepare and characterize nanosuspensions loading the active lactone form of 10-hydroxycamptothecin (10-HCPT). Nanosuspensions…”
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Novel nanostructured lipid-dextran sulfate hybrid carriers overcome tumor multidrug resistance of mitoxantrone hydrochloride by Zhang, Peng, PhD, Ling, Guixia, PhD, Pan, Xiaolei, MS, Sun, Jin, PhD, Zhang, Tianhong, PhD, Pu, Xiaohui, PhD, Yin, Shiliang, PhD, He, Zhonggui, PhD

“…Abstract Novel nanostructured lipid-dextran sulfate hybrid carriers (NLDCs) were successfully developed for sustained delivery of water-soluble cationic…”
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Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions by Yuan, Qi, Wang, Yanling, Song, Rufeng, Hou, Xianqiao, Yu, Keke, Zheng, Jiaojiao, Zhang, Juanmei, Pu, Xiaohui, Han, Jihong, Zong, Lanlan

“…The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the…”
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Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice by Kou, Jiejian, Wang, Minghui, Shi, Junzhuo, Zhang, Haiyu, Pu, Xiaohui, Song, Shiyong, Yang, Cuiling, Yan, Yi, Döring, Yvonne, Xie, Xinmei, Pang, Xiaobin

“…Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer’s disease (AD), but the exact way in which it causes AD remains unclear. Curcumin is…”
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Nanosuspensions of 10-hydroxycamptothecin that can maintain high and extended supersaturation to enhance oral absorption: preparation, characterization and in vitro/in vivo evaluation by Pu, Xiaohui, Sun, Jin, Han, Jihong, Lian, He, Zhang, Peng, Yan, Zhongtian, He, Zhonggui

“…The purpose of the study was to prepare and characterize nanosuspensions that can maintain high and extended supersaturation to improve the dissolution and…”
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Simultaneous determination of tetrahydropalmatine, protopine, and palmatine in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study by Ma, Hongda, Wang, Yongjun, Guo, Tao, He, Zhonggui, Chang, Xinyu, Pu, Xiaohui

“…A sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) method has been developed and validated for the…”
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Bifunctional Peptidomimetic Prodrugs of Didanosine for Improved Intestinal Permeability and Enhanced Acidic Stability: Synthesis, Transepithelial Transport, Chemical Stability and Pharmacokinetics by Yan, Zhongtian, Sun, Jin, Chang, Yannan, Liu, Yanhua, Fu, Qiang, Xu, Youjun, Sun, Yongbing, Pu, Xiaohui, Zhang, Youxi, Jing, Yongkui, Yin, Shiliang, Zhu, Meng, Wang, Yongjun, He, Zhonggui

“…Five peptidomimetic prodrugs of didanosine (DDI) were synthesized and designed to improve bioavailability of DDI following oral administration via targeting…”
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Enhanced paracellular and transcellular paclitaxel permeation by chitosan–vitamin E succinate–N-acetyl-l-cysteine copolymer on Caco-2 cell monolayer by Lian, He, Zhang, Tianhong, Sun, Jin, Pu, Xiaohui, Tang, Yilin, Zhang, Youxi, He, Zhonggui

“…The aim of this study was to evaluate the underlying mechanism of enhanced oral absorption of paclitaxel (PTX)-loaded chitosan–vitamin E succinate– N -acetyl-…”
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Determination of mitoxantrone in rat plasma by liquid chromatography–tandem mass spectrometry method: Application to a pharmacokinetic study by Zhang, Peng, Ling, Guixia, Sun, Jin, Sun, Yongbing, Pu, Xiaohui, Wang, Zhiyuan, He, Zhonggui

“…A rapid, sensitive and specific high performance liquid chromatography–tandem mass spectrometric (HPLC–MS/MS) method has been developed for quantification of…”
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Rapid and sensitive hydrophilic interaction chromatography/tandem mass spectrometry method for the determination of glycyl-sarcosine in cell homogenates by Sun, Yongbing, Sun, Jin, Liu, Jianfang, Yin, Shiliang, Chen, Ying, Zhang, Peng, Pu, Xiaohui, Sun, Yinghua, He, Zhonggui

“…A rapid, selective and sensitive hydrophilic interaction chromatography/tandem mass spectrometry (HILIC/MS/MS) was developed and validated for the…”
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Preparation and antitumor evaluation of quercetin nanosuspensions with synergistic efficacy and regulating immunity by Qiao, Yonghui, Cao, Yanping, Yu, Keke, Zong, Lanlan, Pu, Xiaohui

“…[Display omitted] To study the effect of quercetin (QUR) on modulating immune effects, enhancing anti-tumor activity, and reducing drug related side effects,…”
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A novel design of a damping failure free energy-harvesting shock absorber system by Li, Shiying, Xu, Jun, Pu, Xiaohui, Tao, Tao, Mei, Xuesong

“…•A novel design of energy-harvesting shock absorber control system is proposed.•Damping fluctuation and damping failure zone can be eliminated with the…”
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Energy-harvesting variable/constant damping suspension system with motor based electromagnetic damper by Li, Shiying, Xu, Jun, Pu, Xiaohui, Tao, Tao, Gao, Haonan, Mei, Xuesong

“…Energy-harvesting suspension is very important to improve the energy efficiency of vehicles, especially for electric vehicles. A novel energy-harvesting…”
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A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin by Pu, Xiaohui, Zhao, Luling, Li, Jia, Song, Rufeng, Wang, Yanling, Yu, Keke, Hou, Xianqiao, Qiao, Peng, Zong, Lanlan, Chang, Sheng

“…[Display omitted] Amphiphilic poly(ethylene glycol)-imino-poly(benzyl-l-aspartate) (PIPA) and poly(ethylene glycol)-poly(benzyl-l-aspartate) (PPA) block…”
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Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(β-Benzyl-l-aspartate) (PEG-PBLA) by Zong, Lanlan, Li, Xiaohua, Wang, Haiyan, Cao, Yanping, Yin, Li, Li, Mengmeng, Wei, Zhihao, Chen, Dongxiao, Pu, Xiaohui, Han, Jihong

“…[Display omitted] Amphiphilic block copolymers, PEG-PBLA with different molecular weights, were synthesized and used as new stabilizers for Itraconazole…”
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