Search Results - "Pu, William t."

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease by von Gise, Alexander, Pu, William T

“…Epithelial to mesenchymal transition (EMT) converts epithelial cells to mobile and developmentally plastic mesenchymal cells. All cells in the heart arise from…”
Get full text

Cellular Origin and Developmental Program of Coronary Angiogenesis by Tian, Xueying, Pu, William T, Zhou, Bin

“…Coronary artery disease causes acute myocardial infarction and heart failure. Identifying coronary vascular progenitors and their developmental program could…”
Get full text

Strategies for cardiac regeneration and repair by Lin, Zhiqiang, Pu, William T

“…Heart failure is a growing epidemic caused by cardiomyocyte depletion. Current therapies prolong survival by protecting remaining cardiomyocytes but are unable…”
Get more information

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association by Pierpont, Mary Ella, Brueckner, Martina, Chung, Wendy K., Garg, Vidu, Lacro, Ronald V., McGuire, Amy L., Mital, Seema, Priest, James R., Pu, William T., Roberts, Amy, Ware, Stephanie M., Gelb, Bruce D., Russell, Mark W.

“…This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease. Since 2007,…”
Get full text

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart by He, Aibin, Kong, Sek Won, Ma, Qing, Pu, William T

“…Identification of genomic regions that control tissue-specific gene expression is currently problematic. ChIP and high-throughput sequencing (ChIP-seq) of…”
Get full text

Molecular mechanisms of arrhythmogenic cardiomyopathy by Austin, Karyn M., Trembley, Michael A., Chandler, Stephanie F., Sanders, Stephen P., Saffitz, Jeffrey E., Abrams, Dominic J., Pu, William T.

“…Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-threatening arrhythmias, myocardial dysfunction and fibrofatty…”
Get full text

Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction by Gao, Feng, Kataoka, Masaharu, Liu, Ning, Liang, Tian, Huang, Zhan-Peng, Gu, Fei, Ding, Jian, Liu, Jianming, Zhang, Feng, Ma, Qing, Wang, Yingchao, Zhang, Mingming, Hu, Xiaoyun, Kyselovic, Jan, Hu, Xinyang, Pu, William T., Wang, Jian’an, Chen, Jinghai, Wang, Da-Zhi

“…The primary cause of heart failure is the loss of cardiomyocytes in the diseased adult heart. Previously, we reported that the miR-17-92 cluster plays a key…”
Get full text

Optimization of genome engineering approaches with the CRISPR/Cas9 system by Li, Kai, Wang, Gang, Andersen, Troels, Zhou, Pingzhu, Pu, William T

“…Designer nucleases such as TALENS and Cas9 have opened new opportunities to scarlessly edit the mammalian genome. Here we explored several parameters that…”
Get full text

Enhancing the precision of genetic lineage tracing using dual recombinases by He, Lingjuan, Li, Yan, Li, Yi, Pu, Wenjuan, Huang, Xiuzhen, Tian, Xueying, Wang, Yue, Zhang, Hui, Liu, Qiaozhen, Zhang, Libo, Zhao, Huan, Tang, Juan, Ji, Hongbin, Cai, Dongqing, Han, Zhibo, Han, Zhongchao, Nie, Yu, Hu, Shengshou, Wang, Qing-Dong, Sun, Ruilin, Fei, Jian, Wang, Fengchao, Chen, Ting, Yan, Yan, Huang, Hefeng, Pu, William T, Zhou, Bin

“…Genetic cell-lineage tracing studies in mice are crucial for delineating the contribution of stem and progenitor cells to different cell types, both in disease…”
Get full text

Gene therapy for inherited arrhythmias by Bezzerides, Vassilios J, Prondzynski, Maksymilian, Carrier, Lucie, Pu, William T

“…Abstract Inherited arrhythmias are disorders caused by one or more genetic mutations that increase the risk of arrhythmia, which result in life-long risk of…”
Get full text

Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth by Lin, Zhiqiang, Guo, Haidong, Cao, Yuan, Zohrabian, Sylvia, Zhou, Pingzhu, Ma, Qing, VanDusen, Nathan, Guo, Yuxuan, Zhang, Jin, Stevens, Sean M., Liang, Feng, Quan, Qimin, van Gorp, Pim R., Li, Amy, dos Remedios, Cristobal, He, Aibin, Bezzerides, Vassilios J., Pu, William T.

“…Binding of the transcriptional co-activator YAP with the transcription factor TEAD stimulates growth of the heart and other organs. YAP overexpression potently…”
Get full text

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy by von Gise, Alexander, Lin, Zhiqiang, Schlegelmilch, Karin, Honor, Leah B., Pan, Gina M., Buck, Jessica N., Ma, Qing, Ishiwata, Takahiro, Zhou, Bin, Camargo, Fernando D., Pu, William T.

“…Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart growth occurs through cardiomyocyte proliferation, whereas…”
Get full text

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model by Lin, Zhiqiang, von Gise, Alexander, Zhou, Pingzhu, Gu, Fei, Ma, Qing, Jiang, Jianming, Yau, Allan L, Buck, Jessica N, Gouin, Katryna A, van Gorp, Pim R.R, Zhou, Bin, Chen, Jinghai, Seidman, Jonathan G, Wang, Da-Zhi, Pu, William T

“…RATIONALE:Yes-associated protein (YAP), the terminal effector of the Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation…”
Get full text

Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles by Zhou, Bin, Pu, William T

“…RATIONALE:Wt1-Cre-based tools are important reagents for studying epicardial cell fate and gene function. OBJECTIVE:To better describe the properties of…”
Get full text

De novo formation of a distinct coronary vascular population in neonatal heart by Tian, Xueying, Hu, Tianyuan, Zhang, Hui, He, Lingjuan, Huang, Xiuzhen, Liu, Qiaozhen, Yu, Wei, He, Liang, Yang, Zhen, Yan, Yan, Yang, Xiao, Zhong, Tao P., Pu, William T., Zhou, Bin

“…The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we…”
Get full text

Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II by Bezzerides, Vassilios J, Caballero, Ana, Wang, Suya, Ai, Yulan, Hylind, Robyn J, Lu, Fujian, Heims-Waldron, Danielle A, Chambers, Kristina D, Zhang, Donghui, Abrams, Dominic J, Pu, William T

“…BACKGROUND:Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited cardiac arrhythmia characterized by adrenergically triggered arrhythmias,…”
Get full text

Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity by Ma, Qing, Zhou, Bin, Pu, William T.

“…Isl1 and Nkx2-5-expressing cardiovascular progenitors play pivotal roles in cardiogenesis. Previously reported Cre-based fate-mapping studies showed that Isl1…”
Get full text

A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers by Akerberg, Brynn N., Gu, Fei, VanDusen, Nathan J., Zhang, Xiaoran, Dong, Rui, Li, Kai, Zhang, Bing, Zhou, Bin, Sethi, Isha, Ma, Qing, Wasson, Lauren, Wen, Tong, Liu, Jinhua, Dong, Kunzhe, Conlon, Frank L., Zhou, Jiliang, Yuan, Guo-Cheng, Zhou, Pingzhu, Pu, William T.

“…Mapping the chromatin occupancy of transcription factors (TFs) is a key step in deciphering developmental transcriptional programs. Here we use biotinylated…”
Get full text

Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation by Zhang, Donghui, Li, Yifei, Heims-Waldron, Danielle, Bezzerides, Vassilios, Guatimosim, Silvia, Guo, Yuxuan, Gu, Fei, Zhou, Pingzhu, Lin, Zhiqiang, Ma, Qing, Liu, Jianming, Wang, Da-Zhi, Pu, William T

“…RATIONALE:Although mitochondrial diseases often cause abnormal myocardial development, the mechanisms by which mitochondria influence heart growth and function…”
Get full text

De novo cardiomyocytes from within the activated adult heart after injury by Smart, Nicola, Bollini, Sveva, Dubé, Karina N., Vieira, Joaquim M., Zhou, Bin, Davidson, Sean, Yellon, Derek, Riegler, Johannes, Price, Anthony N., Lythgoe, Mark F., Pu, William T., Riley, Paul R.

“…Repairs of the heart The prospect of cell-based therapy in cardiovascular regenerative medicine comes a step closer with the demonstration that a peptide can…”
Get full text