Search Results - "Pu, Mengchen"

Crystal structures of agonist-bound human cannabinoid receptor CB1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Crystal structures of the human cannabinoid receptor 1 (CB 1 ) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor…”
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Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
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Crystal structure of the Frizzled 4 receptor in a ligand-free state by Yang, Shifan, Wu, Yiran, Xu, Ting-Hai, de Waal, Parker W., He, Yuanzheng, Pu, Mengchen, Chen, Yuxiang, DeBruine, Zachary J., Zhang, Bingjie, Zaidi, Saheem A., Popov, Petr, Guo, Yu, Han, Gye Won, Lu, Yang, Suino-Powell, Kelly, Dong, Shaowei, Harikumar, Kaleeckal G., Miller, Laurence J., Katritch, Vsevolod, Xu, H. Eric, Shui, Wenqing, Stevens, Raymond C., Melcher, Karsten, Zhao, Suwen, Xu, Fei

“…Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in Wnt signalling and are essential for developing and adult organisms…”
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Deep learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures by Zheng, Weisheng, Pu, Mengchen, Li, Xiaorong, Du, Zhaolan, Jin, Sutong, Li, Xingshuai, Zhou, Jielong, Zhang, Yingsheng

“…Metastatic propagation is the leading cause of death for most cancers. Prediction and elucidation of metastatic process is crucial for the treatment of cancer…”
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Native phasing of x-ray free-electron laser data for a G protein-coupled receptor by Batyuk, Alexander, Galli, Lorenzo, Ishchenko, Andrii, Han, Gye Won, Gati, Cornelius, Popov, Petr A, Lee, Ming-Yue, Stauch, Benjamin, White, Thomas A, Barty, Anton, Aquila, Andrew, Hunter, Mark S, Liang, Mengning, Boutet, Sébastien, Pu, Mengchen, Liu, Zhi-Jie, Nelson, Garrett, James, Daniel, Li, Chufeng, Zhao, Yun, Spence, John C H, Liu, Wei, Fromme, Petra, Katritch, Vsevolod, Weierstall, Uwe, Stevens, Raymond C, Cherezov, Vadim

“…Serial femtosecond crystallography (SFX) takes advantage of extremely bright and ultrashort pulses produced by x-ray free-electron lasers (XFELs), allowing for…”
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Using graph-based model to identify cell specific synthetic lethal effects by Pu, Mengchen, Cheng, Kaiyang, Li, Xiaorong, Xin, Yucui, Wei, Lanying, Jin, Sutong, Zheng, Weisheng, Peng, Gongxin, Tang, Qihong, Zhou, Jielong, Zhang, Yingsheng

“…Synthetic lethal (SL) pairs are pairs of genes whose simultaneous loss-of-function results in cell death, while a damaging mutation of either gene alone does…”
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Protein crystal quality oriented disulfide bond engineering by Pu, Mengchen, Xu, Zhijie, Peng, Yao, Hou, Yaguang, Liu, Dongsheng, Wang, Yang, Liu, Haiguang, Song, Gaojie, Liu, Zhi-Jie

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Crystal structures of agonist-bound human cannabinoid receptor CB 1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P, Laprairie, Robert B, Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie

“…The cannabinoid receptor 1 (CB ) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ -tetrahydrocannabinol (Δ -THC)…”
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Modified Electrostatic Complementary Score Function and Its Application Boundary Exploration in Drug Design by Zhao, Liming, Pu, Mengchen, Wang, Huting, Ma, Xiangyu, Zhang, Yingsheng J.

“…In recent years, machine learning (ML) models have been found to quickly predict various molecular properties with accuracy comparable to high-level quantum…”
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Patient-specific analysis of co-expression to measure biological network rewiring in individuals by Wei, Lanying, Xin, Yucui, Pu, Mengchen, Zhang, Yingsheng

“…To effectively understand the underlying mechanisms of disease and inform the development of personalized therapies, it is critical to harness the power of…”
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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology by Peng, Yao, McCorvy, John D., Harpsøe, Kasper, Lansu, Katherine, Yuan, Shuguang, Popov, Petr, Qu, Lu, Pu, Mengchen, Che, Tao, Nikolajsen, Louise F., Huang, Xi-Ping, Wu, Yiran, Shen, Ling, Bjørn-Yoshimoto, Walden E., Ding, Kang, Wacker, Daniel, Han, Gye Won, Cheng, Jianjun, Katritch, Vsevolod, Jensen, Anders A., Hanson, Michael A., Zhao, Suwen, Gloriam, David E., Roth, Bryan L., Stevens, Raymond C., Liu, Zhi-Jie

“…Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs…”
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Structural basis for DNA recognition by STAT6 by Li, Jing, Rodriguez, Jose Pindado, Niu, Fengfeng, Pu, Mengchen, Wang, Jinan, Hung, Li-Wei, Shao, Qiang, Zhu, Yanping, Ding, Wei, Liu, Yanqing, Da, Yurong, Yao, Zhi, Yang, Jie, Zhao, Yongfang, Wei, Gong-Hong, Cheng, Genhong, Liu, Zhi-Jie, Ouyang, Songying

“…STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in…”
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All Ca2+-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg2+-loaded apo-berovin by Burakova, Ludmila P., Natashin, Pavel V., Malikova, Natalia P., Niu, Fengfeng, Pu, Mengchen, Vysotski, Eugene S., Liu, Zhi-Jie

“…Light-sensitive photoprotein berovin accounts for a bright bioluminescence of ctenophore Beroe abyssicola. Berovin is functionally identical to the…”
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Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry by Cheng, Chongyun, Liu, Miaomiao, Gao, Xiaoqin, Wu, Dong, Pu, Mengchen, Ma, Jun, Quinn, Ronald J, Xiao, Zhicheng, Liu, Zhijie

“…The c-Jun N-terminal kinases (JNKs) are evolutionary highly conserved serine/threonine kinases. Numerous findings suggest that JNK3 is involved in the…”
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Comparison of implicit solvent models and force fields in molecular dynamics simulations of the PB1 domain by Pu, Mengchen, Garrahan, Juan P., Hirst, Jonathan D.

“…[Display omitted] . ► MD simulations of a small protein using the EEF1.1 implicit solvent model are performed. ► With the CHARMM19 force field the protein…”
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All Ca(2+)-binding loops of light-sensitive ctenophore photoprotein berovin bind magnesium ions: The spatial structure of Mg(2+)-loaded apo-berovin by Burakova, Ludmila P, Natashin, Pavel V, Malikova, Natalia P, Niu, Fengfeng, Pu, Mengchen, Vysotski, Eugene S, Liu, Zhi-Jie

“…Light-sensitive photoprotein berovin accounts for a bright bioluminescence of ctenophore Beroe abyssicola. Berovin is functionally identical to the…”
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Crystal structures of agonist-bound human cannabinoid receptor CB^sub 1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P, Laprairie, Robert B, Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie

“…The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ-THC)1…”
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Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

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5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology by Peng, Yao, McCorvy, John D, Harpsøe, Kasper, Lansu, Katherine, Yuan, Shuguang, Popov, Petr, Qu, Lu, Pu, Mengchen, Che, Tao, Nikolajsen, Louise F, Huang, Xi-Ping, Wu, Yiran, Shen, Ling, Bjørn-Yoshimoto, Walden E, Ding, Kang, Wacker, Daniel, Han, Gye Won, Cheng, Jianjun, Katritch, Vsevolod, Jensen, Anders A, Hanson, Michael A, Zhao, Suwen, Gloriam, David E, Roth, Bryan L, Stevens, Raymond C, Liu, Zhi-Jie

“…Drugs frequently require interactions with multiple targets-via a process known as polypharmacology-to achieve their therapeutic actions. Currently, drugs…”
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Crystal Structure of the Human Cannabinoid Receptor CB 1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B, Stahl, Edward L, Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie

“…Cannabinoid receptor 1 (CB ) is the principal target of Δ -tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
Get full text