Search Results - "Psychopharmacology"

Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability by Carver, Chase Matthew, Reddy, Doodipala Samba

“…Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on neuronal excitability. Allopregnanolone,…”
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The debate over dopamine's role in reward: the case for incentive salience by Berridge, Kent C

“…Debate continues over the precise causal contribution made by mesolimbic dopamine systems to reward. There are three competing explanatory categories:…”
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Further human evidence for striatal dopamine release induced by administration of Δ9-tetrahydrocannabinol (THC): selectivity to limbic striatum by Bossong, Matthijs G., Mehta, Mitul A., van Berckel, Bart N.M., Howes, Oliver D., Kahn, René S., Stokes, Paul R.A.

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Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3[beta] signaling pathway in hippocampus by Shen, Jun, Qu, Chujie, Xu, Linling, Sun, Huimin, Zhang, Junjian

“…Background Chronic unpredictable mild stress (CUMS) is an important contributing factor for depression with inflammatory response alteration, neuron apoptosis,…”
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Tonic dopamine: opportunity costs and the control of response vigor by Niv, Yael, Daw, Nathaniel D, Joel, Daphna, Dayan, Peter

“…Dopamine neurotransmission has long been known to exert a powerful influence over the vigor, strength, or rate of responding. However, there exists no clear…”
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Realistic expectations of prepulse inhibition in translational models for schizophrenia research by Swerdlow, Neal R., Weber, Martin, Qu, Ying, Light, Gregory A., Braff, David L.

“…Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the startling effects of a subsequent intense abrupt stimulus. This…”
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Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance by Griffiths, R R, Richards, W A, McCann, U, Jesse, R

“…Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. This…”
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Obituary Dr Klaus A Miczek by de Wit, Harriet, Robbins, T. W.

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Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-[kappa]B and IDO-1 by Choubey, Priyansha, Kwatra, Mohit, Pandey, Surya Narayan, Kumar, Dinesh, Dwivedi, Durgesh Kumar, Rajput, Prabha, Mishra, Abhishek

“…Background Fisetin, a plant active polyphenol, is well known for its antioxidant and free radical scavenging activities. The present study was designed to…”
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Guidelines on nicotine dose selection for in vivo research by Matta, Shannon G, Balfour, David J, Benowitz, Neal L, Boyd, R Thomas, Buccafusco, Jerry J, Caggiula, Anthony R, Craig, Caroline R, Collins, Allan C, Damaj, M Imad, Donny, Eric C, Gardiner, Phillip S, Grady, Sharon R, Heberlein, Ulrike, Leonard, Sherry S, Levin, Edward D, Lukas, Ronald J, Markou, Athina, Marks, Michael J, McCallum, Sarah E, Parameswaran, Neeraja, Perkins, Kenneth A, Picciotto, Marina R, Quik, Maryka, Rose, Jed E, Rothenfluh, Adrian, Schafer, William R, Stolerman, Ian P, Tyndale, Rachel F, Wehner, Jeanne M, Zirger, Jeffrey M

“…This review provides insight for the judicious selection of nicotine dose ranges and routes of administration for in vivo studies. The literature is replete…”
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Functions of mesolimbic dopamine: changing concepts and shifting paradigms by Salamone, John D

“…Issue Title: Dopamine - revisited…”
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Models and mechanisms of anxiety: evidence from startle studies by Grillon, Christian

“…Rationale Preclinical data indicates that threat stimuli elicit two classes of defensive behaviors, those that are associated with imminent danger and are…”
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Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence by Vignal, Lucie, Vielle, Cassandre, Williams, Maya, Maurice, Nicolas, Degoulet, Mickael, Baunez, Christelle

“…Rationale The immediate social context significantly influences alcohol consumption in humans. Recent studies have revealed that peer presence could modulate…”
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The 5-HT.sub.1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models by Papp, Mariusz, Gruca, Piotr, Lason, Magdalena, Litwa, Ewa, Newman-Tancredi, Adrian, Depoortère, Ronan

“…Objectives NLX-101 and NLX-204 are highly selective serotonin 5-HT.sub.1A 'biased' agonists, displaying potent and efficacious antidepressant-like activity…”
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Effort-related effects of chronic administration of the DA D.sub.2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co-administration of the adenosine A2A antagonist istradefylline by Rotolo, Renee A, Ecevitoglu, Alev, Presby, Rose E, Lindgren, Hanna, Mombereau, Cedric, Nicholas, Cyrene, Moore, Alana, Edelstein, Gayle A, Correa, Merce, Salamone, John D

“…Rationale Long-acting antipsychotics such as haloperidol decanoate are becoming more commonly used. Long-acting depot formulations have several advantages, but…”
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Effect of the mGlu.sub.4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset by Frouni, Imane, Kwan, Cynthia, Bédard, Dominique, Kang, Woojin, Hamadjida, Adjia, Nuara, Stephen G, Gourdon, Jim C, Huot, Philippe

“…Rationale Positive allosteric modulation of metabotropic glutamate type 4 (mGlu.sub.4) receptors is a promising strategy to alleviate parkinsonian disability…”
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Characterization of behavioral changes in T-maze alternation from dopamine D.sub.1 agonists with different receptor coupling mechanisms by Cimino, Jack X, Zhou, Mi, Waxmonsky, James, Mailman, Richard B, Yang, Yang

“…Rationale Dopamine D.sub.1 receptor agonists have been shown to improve working memory, but often have a non-monotonic (inverted-U) dose-response curve. One…”
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Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization by Levin, Edward D, McClernon, F Joseph, Rezvani, Amir H

“…Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as…”
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Neuroprotective effect of salidroside on hippocampal neurons in diabetic mice via PI3K/Akt/GSK-3[beta] signaling pathway by Wang, Xue-Hua, Zuo, Zhong-Fu, Meng, Lu, Yang, Qi, Lv, Pan, Zhao, Li-Pan, Wang, Xiao-Bai

“…Background Diabetic encephalopathy is manifested by cognitive dysfunction. Salidroside, a nature compound isolated from Rhodiola rosea L, has the effects of…”
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18[beta]-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype by Luo, Hanyue, Zhang, Caishi, He, Lujuan, Lin, Zefang, Zhang, Ji-chun, Qi, Qi, Chen, Jia-xu

“…Rationale 18[beta]-glycyrrhetinic acid (18[beta]-GA) has been reported to have anti-inflammatory and neuroprotective effects. However, the therapeutic effect…”
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