The role of the endogenous opioid system in the mechanisms of the development of early postradiation autonomic and behavioral disorders

In the experiments with rats and dogs it was shown that irradiation within the dose range of 50-100 Gy is accompanied by the increasing of enkephaline content in various brain structures and beta-endorphine level in blood plasma. The blocking of the opiate receptors naloxone promotes the decrease of...

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Bibliographic Details
Published in:	Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 35; no. 2; p. 195
Main Authors:	Legeza, V I, Shagoian, M G, Panov, A N, Pshenkina, N I, Buriakova, L V, Turlakov, Iu S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-03-1995
Subjects:	Animals Autonomic Nervous System Diseases - etiology Autonomic Nervous System Diseases - metabolism Behavior, Animal - drug effects Behavior, Animal - radiation effects Brain - drug effects Brain - metabolism Brain - radiation effects Brain Chemistry - drug effects Brain Chemistry - radiation effects Cesium Radioisotopes Dogs Male Naloxone - pharmacology Opioid Peptides - physiology Opioid Peptides - radiation effects Radiation Injuries, Experimental - etiology Radiation Injuries, Experimental - metabolism Rats Receptors, Opioid - drug effects Receptors, Opioid - physiology Receptors, Opioid - radiation effects Time Factors Whole-Body Irradiation
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Summary:	In the experiments with rats and dogs it was shown that irradiation within the dose range of 50-100 Gy is accompanied by the increasing of enkephaline content in various brain structures and beta-endorphine level in blood plasma. The blocking of the opiate receptors naloxone promotes the decrease of post-radiation vomiting in dogs, gastrostasis and hypokinesia in rats. That supports the participation of endogenous opioid system in the primary clinical reaction response to irradiation.
ISSN:	0869-8031