Search Results - "Psatha, Nikoleta"

526. Specific Companion Cells Enhance the Engraftment of Ex-Vivo Expanded HSCs (CD34+/CD38−/CD90+) by Psatha, Nikoleta, Papayannopoulou, Thalia

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Empowering the Potential of CAR-T Cell Immunotherapies by Epigenetic Reprogramming by Alvanou, Maria, Lysandrou, Memnon, Christophi, Panayota, Psatha, Nikoleta, Spyridonidis, Alexandros, Papadopoulou, Anastasia, Yannaki, Evangelia

“…T-cell-based, personalized immunotherapy can nowadays be considered the mainstream treatment for certain blood cancers, with a high potential for expanding…”
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Promises and Pitfalls of Next-Generation Treg Adoptive Immunotherapy by Christofi, Panayiota, Pantazi, Chrysoula, Psatha, Nikoleta, Sakellari, Ioanna, Yannaki, Evangelia, Papadopoulou, Anastasia

“…Regulatory T cells (Tregs) are fundamental to maintaining immune homeostasis by inhibiting immune responses to self-antigens and preventing the excessive…”
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Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation by Bravo González-Blas, Carmen, Matetovici, Irina, Hillen, Hanne, Taskiran, Ibrahim Ihsan, Vandepoel, Roel, Christiaens, Valerie, Sansores-García, Leticia, Verboven, Elisabeth, Hulselmans, Gert, Poovathingal, Suresh, Demeulemeester, Jonas, Psatha, Nikoleta, Mauduit, David, Halder, Georg, Aerts, Stein

“…In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear…”
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Introduction of Two Simultaneous Mutations By Genome Editing Greatly Enhances the Accumulation of the Endogenous Fetal Hemoglobin in Human Normal Erythroid Cells by Psatha, Nikoleta, Li, Chang, Wang, Hongjie, Dalas, Demetri, Stamatoyannopoulos, George, Papayannopoulou, Thalia, Lieber, Andre

“…Thalassemia or sickle cell patients with increased fetal hemoglobin have an ameliorated clinical picture up to transfusion independency. Genome editing with…”
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The diverse genetic origins of a Classical period Greek army by Reitsema, Laurie J, Mittnik, Alissa, Kyle, Britney, Catalano, Giulio, Fabbri, Pier Francesco, Kazmi, Adam C S, Reinberger, Katherine L, Sineo, Luca, Vassallo, Stefano, Bernardos, Rebecca, Broomandkhoshbacht, Nasreen, Callan, Kim, Candilio, Francesca, Cheronet, Olivia, Curtis, Elizabeth, Fernandes, Daniel, Lari, Martina, Lawson, Ann Marie, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Modi, Alessandra, Oppenheimer, Jonas, Özdogan, Kadir Toykan, Rohland, Nadin, Stewardson, Kristin, Vai, Stefania, Vergata, Chiara, Workman, J Noah, Zalzala, Fatma, Zaro, Valentina, Achilli, Alessandro, Anagnostopoulos, Achilles, Capelli, Cristian, Constantinou, Varnavas, Lancioni, Hovirag, Olivieri, Anna, Papadopoulou, Anastasia, Psatha, Nikoleta, Semino, Ornella, Stamatoyannopoulos, John, Valliannou, Ioanna, Yannaki, Evangelia, Lazaridis, Iosif, Patterson, Nick, Ringbauer, Harald, Caramelli, David, Pinhasi, Ron, Reich, David

“…Trade and colonization caused an unprecedented increase in Mediterranean human mobility in the first millennium BCE. Often seen as a dividing force, warfare is…”
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Thalassemia Gene Therapy By In Vivo Transduction of Mobilized Hematopoietic Stem Cells (HSCs) with an Integrating Hybrid Adenovirus Vector System by Georgakopoulou, Afrodite, Wang, Hongjie, Kapsali, Chrysi, Psatha, Nikoleta, Koufali, Angeliki, Li, Chang, Izsvak, Zsuzsanna, Anagnostopoulos, Achilles, Papayannopoulou, Thalia, Yannaki, Evangelia, Lieber, Andre

“…To overcome the cost and complexity of current thalassemia ex vivogene therapy protocols, we developed a minimally invasive and readily translatable approach…”
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In Vivo HSC Transduction and Selection Results in Long-Term, High-Level Expression of Human Gamma Globin in Peripheral Blood Erythrocytes of Mice by Lieber, Andre, Wang, Hongjie, Psatha, Nikoleta, Li, Chang, Haworth, Kevin G, Ehrhardt, Anja, Izsvak, Zsuzsanna, Kiem, Hans-Peter, Stamatoyannopoulos, George, Papayannopoulou, Thalia

“…Current protocols for HSC gene therapy, involving the transplantation of ex vivo lentivirus vector-transduced HSCs into myeloablated recipients, are complex…”
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Hematopoietic Stem Cell Mobilization for Gene Therapy of Adult Patients With Severe β-Thalassemia: Results of Clinical Trials Using G-CSF or Plerixafor in Splenectomized and Nonsplenectomized Subjects by Yannaki, Evangelia, Papayannopoulou, Thalia, Jonlin, Erica, Zervou, Fani, Karponi, Garyfalia, Xagorari, Angeliki, Becker, Pamela, Psatha, Nikoleta, Batsis, Ioannis, Kaloyannidis, Panayotis, Tahynopoulou, Varvara, Constantinou, Varnavas, Bouinta, Asimina, Kotta, Konstantia, Athanassiadou, Aglaia, Anagnostopoulos, Achilles, Fassas, Athanasios, Stamatoyannopoulos, George

“…The safety and efficacy of hematopoietic stem cell (HSC) mobilization was investigated in adult splenectomized (SPL) and non-SPL patients with thalassemia…”
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Plerixafor+G-CSF-Mobilized Blood From Thalassemic Mice Provides High Yields Of Long-Term Repopulating Cells With Enhanced Engrafting Capacity : Implications For Human Stem Cell Gene Therapy by Psatha, Nikoleta, Sgouramali, Eleni, Siametis, Athanasios, Siapati, Elena, Baliakas, Panayotis, Constantinou, Varnavas, Anagnostopoulos, Achilles, Papayannopoulou, Thalia, Stamatoyannopoulos, George, Yannaki, Evangelia

“…A durable therapeutic effect of gene therapy in β-thalassemia largely depends on the infusion of high numbers of genetically-modified hematopoietic stem cells…”
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Superior long-term repopulating capacity of G-CSF+plerixafor-mobilized blood: implications for stem cell gene therapy by studies in the Hbb(th-3) mouse model by Psatha, Nikoleta, Sgouramali, Eleni, Gkountis, Antonios, Siametis, Athanasios, Baliakas, Panayotis, Constantinou, Varnavas, Athanasiou, Evangelia, Arsenakis, Minas, Anagnostopoulos, Achilles, Papayannopoulou, Thalia, Stamatoyannopoulos, George, Yannaki, Evangelia

“…High numbers of genetically modified hematopoietic stem cells (HSCs) equipped with enhanced engrafting potential are required for successful stem cell gene…”
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Hematopoietic Cell Mobilization for Gene Therapy of Adult Patients with Severe Beta-Thalassemia: The Challenge of Splenectomy and the Role of Plerixafor by Yannaki, Evangelia, Papayannopoulou, Thalia, Jonlin, Erica, Zervou, Fani, Karponi, Garyfalia, Xagorari, Angeliki, Becker, Pamela S., Psatha, Nikoleta, Batsis, Ioannis, Kaloyannidis, Panayotis, Tahynopoulou, Varvara, Constantinou, Varnavas, Bouinta, Asimenia, Kotta, Konstantia, Athanassiadou, Aglaia, Anagnostopoulos, Achilles, Fassas, Athanasios, Stamatoyannopoulos, George

“…Abstract 166▪FN2▪This icon denotes a clinically relevant abstract In preparation for a trial for gene therapy of thalassemia, we investigated the safety and…”
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The Combination of AMD3100 + G-CSF Restores the Ineffective Hematopoietic Stem Cell Mobilization with G-CSF Alone in a Thalassemic Mouse Model by Yannaki, Evangelia, Psatha, Nikoleta, Demertzi, Maria, Athanasiou, Evangelia, Sgouramali, Eleni, Bougiouklis, Dimitris, Arsenakis, Minas, Anagnostopoulos, Achilles, Fassas, Athanasios

“…Abstract 3234 Poster Board III-171 Gene therapy has been recently postulated as a realistic therapeutic potential for thalassemia and the mobilized autologous…”
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Hematopoietic Stem Cell Mobilization for Gene Therapy of Adult Patients With Severe [beta]-Thalassemia: Results of Clinical Trials Using G-CSF or Plerixafor in Splenectomized and Nonsplenectomized Subjects by Yannaki, Evangelia, Papayannopoulou, Thalia, Jonlin, Erica, Zervou, Fani, Karponi, Garyfalia, Xagorari, Angeliki, Becker, Pamela, Psatha, Nikoleta, Batsis, Ioannis, Kaloyannidis, Panayotis, Tahynopoulou, Varvara, Constantinou, Varnavas, Bouinta, Asimina, Kotta, Konstantia, Athanassiadou, Aglaia, Anagnostopoulos, Achilles, Fassas, Athanasios, Stamatoyannopoulos, George

“…The safety and efficacy of hematopoietic stem cell (HSC) mobilization was investigated in adult splenectomized (SPL) and non-SPL patients with thalassemia…”
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Mobilization of hematopoietic stem cells in a thalassemic mouse model: implications for human gene therapy of thalassemia by Yannaki, Evangelia, Psatha, Nikoleta, Athanasiou, Evangelia, Karponi, Garyfalia, Constantinou, Varnavas, Papadopoulou, Anastasia, Tasouli, Athanasia, Kaloyannidis, Panayotis, Batsis, Ioannis, Arsenakis, Minas, Anagnostopoulos, Achilles, Fassas, Athanasios

“…Granulocyte colony-stimulating factor (G-CSF)-mobilized blood stem cells may become the preferable source of hematopoietic stem cells (HSCs) for gene therapy…”
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