Delusional disorder, somatic type treated with aripiprazole—mirtazapine combination

Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies. Initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryc...

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Bibliographic Details
Published in:	Journal of psychopharmacology (Oxford) Vol. 22; no. 7; pp. 812 - 814
Main Authors:	Dimopoulos, NP, Mitsonis, CI, Psarra, VV
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-09-2008 Sage Sage Publications Ltd. (UK) Sage Publications Ltd
Subjects:	Antidepressants Antidepressive Agents, Tricyclic - therapeutic use Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Aripiprazole Biological and medical sciences Case studies Delusional disorder Delusions Drug therapy Drug Therapy, Combination Employment Female Humans Inhibitor drugs Medical sciences Mental disorders Mianserin - analogs & derivatives Mianserin - therapeutic use Middle Aged Neuropharmacology Pharmacology. Drug treatments Piperazines - adverse effects Piperazines - therapeutic use Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Quinolones - adverse effects Quinolones - therapeutic use Schizophrenia Schizophrenia, Paranoid - diagnosis Schizophrenia, Paranoid - drug therapy Schizophrenia, Paranoid - psychology Social Behavior aripiprazole mirtazapine somatic type delusional disorder 5-HT2A serotonin receptor α2-Adrenergic receptor Partial agonist Neuroleptic Psychotropic Quinolinone derivatives Delusion Tetracyclic compound Aripiprazole D2 Dopamine receptor 5-HT1A Serotonine receptor Mirtazapine Antidepressant agent Antagonist Somatic disease
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Summary:	Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of well-organized studies. Initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryciclic anti—depressants and selective serotonin re—uptake inhibitors (SSRIs) were also suggested to be effective, implicating the serotonergic system in the pathophysiology of the disorder. We present the case of a female with DDST, who responded to aripiprazole—mirtazapine combination, a finding that is in accordance with the initial approach of this disorder as a part of the schizophrenic spectrum, but also supports the hypothesis of serotonin dysfunction in DDST.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0269-8811 1461-7285
DOI:	10.1177/0269881107082905