Search Results - "Pryce, Benjamin R."

Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia by Spadafora, Victoria, Pryce, Benjamin R, Oles, Alexander, Talbert, Erin E, Romeo, Martin, Vaena, Silvia, Berto, Stefano, Ostrowski, Michael C, Wang, David J, Guttridge, Denis C

“…Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is…”
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Periostin gene expression in neu-positive breast cancer cells is regulated by a FGFR signaling cross talk with TGFβ/PI3K/AKT pathways by Labrèche, Cédrik, Cook, David P, Abou-Hamad, John, Pascoal, Julia, Pryce, Benjamin R, Al-Zahrani, Khalid N, Sabourin, Luc A

“…Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein involved in…”
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Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia by Pryce, Benjamin R., Oles, Alexander, Talbert, Erin E., Romeo, Martin J., Vaena, Silvia, Sharma, Sudarshana, Spadafora, Victoria, Tolliver, Lauren, Mahvi, David A., Morgan, Katherine A., Lancaster, William P., Beal, Eryn, Koren, Natlie, Watts, Bailey, Overstreet, Morgan, Berto, Stefano, Subramanian, Suganya, Calisir, Kubra, Crawford, Anna, Neelon, Brian, Ostrowski, Michael C., Zimmers, Teresa A., Tidball, James G., Wang, David J., Guttridge, Denis C.

“…Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with…”
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Cancer cachexia: involvement of an expanding macroenvironment by Pryce, Benjamin R., Wang, David J., Zimmers, Teresa A., Ostrowski, Michael C., Guttridge, Denis C.

“…Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The…”
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The Ste20-like kinase - a Jack of all trades? by Garland, Brennan, Delisle, Samuel, Al-Zahrani, Khalid N, Pryce, Benjamin R, Sabourin, Luc A

“…Over the past 20 years, the Ste20-like kinase (SLK; also known as STK2) has emerged as a central regulator of cytoskeletal dynamics. Reorganization of the…”
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The LIM domain binding protein 1, Ldb1, has distinct roles in Neu-induced mammary tumorigenesis by Ahmed, Sarra, Pryce, Benjamin R., Al-Zahrani, Khalid N., Sabourin, Luc A.

“…We have previously shown that the Ste20-like kinase SLK interacts directly with the LIM domain-binding protein 1, Ldb1. Ldb1 knock down in murine fibroblasts…”
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Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice by Pryce, Benjamin R, Labrèche, Cédrik, Hamoudi, Dounia, Abou-Hamad, John, Al-Zahrani, Khalid N, Hodgins, Jonathan J, Boulanger-Piette, Antoine, Bossé, Sabrina, Balog-Alvarez, Cindy, Frénette, Jérôme, Ardolino, Michele, Kornegay, Joe N, Sabourin, Luc A

“…Duchenne's muscular dystrophy (DMD) is a severe muscle wasting disorder characterized by the loss of dystrophin expression, muscle necrosis, inflammation and…”
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Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers by Al-Zahrani, Khalid N., Abou-Hamad, John, Cook, David P., Pryce, Benjamin R., Hodgins, Jonathan J., Labrèche, Cédrik, Robineau-Charette, Pascale, de Souza, Christiano T., Bell, John C., Auer, Rebecca C., Ardolino, Michele, Vanderhyden, Barbara C., Sabourin, Luc A.

“…HER2 is overexpressed in 20–30% of all breast cancers and is associated with an invasive disease and poor clinical outcome. The Ste20-like kinase (SLK) is…”
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Transforming growth factor β-induced epithelial to mesenchymal transition requires the Ste20-like kinase SLK independently of its catalytic activity by Conway, Jillian, Al-Zahrani, Khalid N, Pryce, Benjamin R, Abou-Hamad, John, Sabourin, Luc A

“…Invasion can be stimulated using the soluble ligand transforming growth factor-β (TGFβ) to induce a process called epithelial-to-mesenchymal transition (EMT)…”
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Essential role for the SLK protein kinase in embryogenesis and placental tissue development by Al‐Zahrani, Khalid N., Sekhon, Prabhjot, Tessier, Daniel R., Yockell‐Lelievre, Julien, Pryce, Benjamin R., Baron, Kyla D., Howe, Grant A., Sriram, Roshan K., Daniel, Kate, Mckay, Marlene, Lo, Vivian, Quizi, Jennifer, Addison, Christina L., Gruslin, Andrée, Sabourin, Luc A.

“…Background: Over the past decade, the Ste20‐like kinase SLK, has been implicated in several signaling processes. SLK repression has been shown to impair cell…”
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Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness by Pryce, Benjamin R, Al-Zahrani, Khalid N, Dufresne, Sébastien, Belkina, Natalya, Labrèche, Cédrik, Patino-Lopez, Genaro, Frenette, Jérôme, Shaw, Stephen, Sabourin, Luc A

“…The Ste20-like kinase, SLK, plays an important role in cell proliferation and cytoskeletal remodeling. In fibroblasts, SLK has been shown to respond to FAK/Src…”
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Periostin gene expression in neu-positive breast cancer cells is regulated by a FGFR signaling cross talk with TGF[beta]/PI3K/AKT pathways by Labrèche, Cédrik, Cook, David P, Abou-Hamad, John, Pascoal, Julia, Pryce, Benjamin R, Al-Zahrani, Khalid N, Sabourin, Luc A

“…Background Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein…”
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Abstract B007: Optimization of an Orthotopic Mouse Model of Pancreatic Cancer to Simulate Liver Metastasis and Cancer Cachexia by Wang, David J, Spadafora, Victoria, Pryce, Benjamin R, Oles, Alexander, Talbert, Erin E, Ostrowski, Micheal C, Guttridge, Denis C

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a poor prognosis due to two key features. The first is metastasis at presentation,…”
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Abstract B014: NF-kB Regulates Innate Immunity in the Muscle Microenvironment to Control Distinct States of Wasting in Pancreatic Cancer-Induced Cachexia by Guttridge, Denis C, Pryce, Benjamin R, Oles, Alexander, Talbert, Erin E, Morgan, Katherine A, Mahvi, David A, Ostrowski, Michael C, Zimmers, Teresa A, Tidball, James G, Wang, David J

“…Cancer cachexia is a debilitating syndrome characterized by unintentional weight loss largely due to the depletion of adipose and skeletal muscle mass…”
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