Search Results - "Pruzan, R."

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT by Weinrich, Scott L, Pruzan, Ron, Ma, Libin, Ouellette, Michel, Tesmer, Valeric M, Holt, Shawn E, Bodnar, Andrea G, Lichtsteiner, Serge, Kim, Nam W, Trager, James B, Taylor, Rebecca D, Carlos, Ruben, Andrews, William H, Wright, Woodring E, Shay, Jerry W, Harley, Calvin B, Morin, Gregg B

“…The maintenance of chromosome termini, or telomeres, requires the action of the enzyme telomerase, as conventional DNA polymerases cannot fully replicate the…”
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Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates by Pruzan, Ronald, Pongracz, Krisztina, Gietzen, Kimberly, Wallweber, Gerald, Gryaznov, Sergei

“…Telomerase is a ribonucleoprotein responsible for maintaining telomeres in nearly all eukaryotic cells. The enzyme is able to utilize a short segment of its…”
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Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA by Autexier, C., Pruzan, R., Funk, W. D., Greider, C. W.

“…Telomerase is a ribonucleoprotein that catalyzes telomere elongation through the addition of TTAGGG repeats in humans. Activation of telomerase is often…”
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TELOMERASE INHIBITORS - OLIGONUCLEOTIDE PHOSPHORAMIDATES AS POTENTIAL THERAPEUTIC AGENTS by Gryaznov, S., Pongracz, K., Matray, T., Schultz, R., Pruzan, R., Aimi, J., Chin, A., Harley, C., Shea-Herbert, B., Shay, J., Oshima, Y., Asai, A., Yamashita, Y.

“…We have designed, synthesized, and evaluated using physical, chemical and biochemical assays various oligonucleotide N3′ → P5′ phosphoramidates, as potential…”
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Transcription of adenovirus RNA polymerase III genes by Pruzan, R, Flint, S J

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Communicating with older patients: a challenge for researchers and clinicians by Hodes, R J, Ory, M G, Pruzan, M R

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In vivo Transcription from the Adenovirus E2 Early Promoter by RNA Polymerase III by Huang, Wenlin, Pruzan, R., Flint, S. J.

“…We have previously reported that the subgroup C adenovirus E2 early (E2E) RNA polymerase II promoter can specify efficient in vitro transcription by RNA…”
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A novel telomerase template antagonist (GRN163) as a potential anticancer agent by ASAI, Akira, OSHIMA, Yuko, PIATYSZEK, Mieczyslaw, SHIHONG LI, CHIN, Allison C, HARLEY, Calvin B, GRYAZNOV, Sergei, YAMAMOTO, Yoshihiro, UOCHI, Taka-Aki, KUSAKA, Hideaki, AKINAGA, Shiro, YAMASHITA, Yoshinori, PONGRACZ, Krisztina, PRUZAN, Ronald, WUNDER, Ellen

“…Telomerase, the enzyme responsible for proliferative immortality, is expressed in essentially all cancer cells, but not in most normal human cells. Thus,…”
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Interaction of Human Telomerase with Its Primer Substrate by Wallweber, Gerald, Gryaznov, Sergei, Pongracz, Krisztina, Pruzan, Ronald

“…Telomerase is a ribonucleoprotein responsible for maintaining the ends of linear chromosomes in nearly all eukaryotic cells. In humans, expression of the…”
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Assemblage of the prespliceosome complex with separated fractions isolated from HeLa cells by PRUZAN, R, FURNEAUX, H, LASSOTA, P, HONG, G. Y, HURWITZ, J

“…The first ATP-dependent complex formed in pre-mRNA splicing is the prespliceosome, a 30 S complex. This reaction was investigated using partially purified…”
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Purification of an active TATA-binding protein-containing factor using a monoclonal antibody that recognizes the human TATA-binding protein by Chatterjee, P K, Pruzan, R, Flint, S J

“…The human TATA-binding protein was expressed in Escherichia coli as a fusion with an N-terminal hexahistidine sequence, partially purified, and used to raise…”
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Mucoepidermoid carcinoma in a young adult: recognition, diagnosis, and treatment and responsibility by Epstein, Joel B, Hollender, Lars, Pruzan, Steven R

“…Recognizing an abnormality is the first and most essential step when diagnosing a pathosis. All health care providers are responsible for evaluating suspicious…”
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In vitro premature termination in SV40 late transcription by Pfeiffer, P., Hay, N., Pruzan, R., Jakobovits, E.B., Aloni, Y.

“…Nuclear extracts and viral transcribing minichromosomes were prepared from SV40‐infected cells and incubated in vitro with [alpha‐32P]UTP under conditions…”
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Allosteric inhibitors of telomerase: oligonucleotide N3' arrow right P5' phosphoramidates by Pruzan, R, Pongracz, K, Gietzen, K, Wallweber, G, Gryaznov, S

“…Telomerase is a ribonucleoprotein responsible for maintaining telomeres in nearly all eukaryotic cells. The enzyme is able to utilize a short segment of its…”
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Oligonucleotide N3′ → P5′ Thio-phosphoramidate Telomerase Template Antagonists as Potential Anticancer Agents by Gryaznov, Sergei, Asai, Akira, Oshima, Yuko, Yamamoto, Yoshihiro, Pongracz, Krisztina, Pruzan, Ronald, Wunder, Ellen, Piatyszek, Mieczyslaw, Li, Shihong, Chin, Allison, Harley, Calvin, Akinaga, Shiro, Yamashita, Yoshinori

“…Human telomerase is a reverse transcriptase that is expressed in essentially all cancer cells, but not in the vast majority of normal somatic cells. Therefore,…”
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In vivo transcription from the adenovirus E2 earlypromoter by RNA polymerase III by Huang, W, Pruzan, R, Flint, S J

“…We have previously reported that the subgroup C adenovirus E2 early (E2E) RNA polymerase II promoter can specify efficient in vitro transcription by RNA…”
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Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase by Pongracz, Krisztina, Li, Shihong, Herbert, Brittney-Shea, Pruzan, Ronald, Wunder, Ellen, Chin, Allison, Piatyszek, Mieczyslaw, Shay, Jerry, Gryaznov, Sergei M.

“…A series of oligonucleotide conjugates were designed and synthesized as novel inhibitors of human telomerase. These compounds contain a relatively short…”
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Specific transcription from the adenovirus E2E promoter by RNA polymerase III requires a subpopulation of TFIID by Pruzan, R, Chatterjee, P K, Flint, S J

“…The early E2 (E2E) promoter of adenovirus type 2 possesses a TATA-like element and binding sites for the factors E2F and ATF. This promoter is transcribed by…”
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Specific transcription from the adenovirus E2E promoter by RNA polymerase III requires a subpopulation of TFIID by Pruzan, Ronald, Chatterjee, Pradeep K., Flint, S.J.

“…The early E2 (E2E) promoter of adenovirus type 2 possesses a TATA-like element and binding sites for the factors E2F and ATF. This promoter is transcribed by…”
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Elements involved in an in vitro block to transcription elongation at the end of the L1 mRNA family of adenovirus 2 by RESNEKOV, O, PRUZAN, R, ALONI, Y

“…Using the 3' end of the L1 mRNA family of adenovirus 2 (Ad2) as a model system, we investigated transcription elongation following a poly(A) signal in a…”
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