Search Results - "Pruschy, Martin N"

Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation by Fontana, Andrea O, Augsburger, Marc A, Grosse, Nicole, Guckenberger, Matthias, Lomax, Anthony J, Sartori, Alessandro A, Pruschy, Martin N

“…Abstract Background and purpose Non-homologous end-joining (NHEJ) and homologous recombination (HR) contribute to the repair of irradiation-induced DNA…”
Get full text

Secretome Signature Identifies ADAM17 as Novel Target for Radiosensitization of Non-Small Cell Lung Cancer by Sharma, Ashish, Bender, Sabine, Zimmermann, Martina, Riesterer, Oliver, Broggini-Tenzer, Angela, Pruschy, Martin N

“…Ionizing radiation (IR) induces intracellular signaling processes as part of a treatment-induced stress response. Here we investigate IR-induced ADAM17…”
Get full text

Abstract LB-151: The novel tubulin-binding, tumor checkpoint controller BAL101553 has differential effects on tumor vascularization with IV and oral dosing and provides superior anti-tumor activity in combination with bevacizumab by Sharma, Ashish, Bachmann, Felix, Broggini-Tenzer, Angela, Guckenberger, Matthias, Lane, Heidi, Pruschy, Martin N.

“…Abstract Background: BAL101553 is a highly soluble prodrug of BAL27862, a novel, small molecule, microtubule-depolymerizer inducing tumor cell death through…”
Get full text

Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012 by Pruschy, M N, Spencer, D M, Kapoor, T M, Miyake, H, Crabtree, G R, Schreiber, S L

“…The T-cell receptor (TCR) signaling pathway is initiated by regulated association of TCR chains, including the zeta chain. A recently reported method for…”
Get more information