Search Results - "Prusakiewicz, Jeffery J"

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 by Duggan, Kelsey C, Hermanson, Daniel J, Musee, Joel, Prusakiewicz, Jeffery J, Scheib, Jami L, Carter, Bruce D, Banerjee, Surajit, Oates, J A, Marnett, Lawrence J

“…Rapid reversible inhibitors of the oxygenation activity of COX-2, including ibuprofen and naproxen, selectively inhibit the enzyme with endocannabinoid 2-AG…”
Get full text

Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid by Prusakiewicz, Jeffery J, Duggan, Kelsey C, Rouzer, Carol A, Marnett, Lawrence J

“…Ibuprofen and mefenamic acid are weak, competitive inhibitors of cyclooxygenase-2 (COX-2) oxygenation of arachidonic acid (AA) but potent, noncompetitive…”
Get full text

Hydrolysis of a series of parabens by skin microsomes and cytosol from human and minipigs and in whole skin in short-term culture by Jewell, Christopher, Prusakiewicz, Jeffery J., Ackermann, Chrisita, Payne, N. Ann, Fate, Gwendolyn, Voorman, Richard, Williams, Faith M.

“…Parabens are esters of 4-hydroxybenzoic acid and used as anti-microbial agents in a wide variety of toiletries, cosmetics and pharmaceuticals. It is of…”
Get full text

Comparison of skin esterase activities from different species by PRUSAKIEWICZ, Jeffery J, ACKERMANN, Chrisita, VOORMAN, Richard

“…Many topically applied drugs contain esters that are hydrolyzed in the skin. Minipigs have emerged as potential models of human dermatology and, in some…”
Get full text

A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385 by Rowlinson, Scott W., Kiefer, James R., Prusakiewicz, Jeffery J., Pawlitz, Jennifer L., Kozak, Kevin R., Kalgutkar, Amit S., Stallings, William C., Kurumbail, Ravi G., Marnett, Lawrence J.

“…A variety of drugs inhibit the conversion of arachidonic acid to prostaglandin G2 by the cyclooxygenase (COX) activity of prostaglandin endoperoxide synthases…”
Get full text

Multiple Natural and Experimental Inflammatory Rabbit Lacrimal Gland Phenotypes by Mircheff, Austin K., PhD, Wang, Yanru, MD, PhD, Schechter, Joel E., MD, Li, Meng, MS, Tong, Warren, PharmD, MS, Attar, Mayssa, PhD, Chengalvala, Murty, PhD, Harmuth, Joe, BS, Prusakiewicz, Jeffery J., PhD

“…Abstract Purpose To investigate lacrimal gland (LG) immunophysiological and immune-mediated inflammatory process (IMIP) phenotype diversity Methods Ex vivo…”
Get full text

Pharmacokinetics and intraocular pressure–lowering activity of TAK-639, a novel C-type natriuretic peptide analog, in rabbit, dog, and monkey by Savinainen, Anneli, Prusakiewicz, Jeffery J., Oswald, Justine, Spencer, Elizabeth, Lou, Zhen, Cohen, Marita Larsson, Rashidzadeh, Hassan, Josiah, Serene

“…TAK-639 is a topical, 9–amino acid, synthetic, C-type natriuretic peptide analog in development for the treatment of primary open-angle glaucoma and ocular…”
Get full text

The distribution of esterases in the skin of the minipig by Jewell, Christopher, Prusakiewicz, Jeffery J., Ackermann, Chrisita, Payne, N. Ann, Fate, Gwendolyn, Williams, Faith M.

“…Skin esterases serve an important pharmacological function as they can be utilised for activation of topically applied ester prodrugs. Understanding the nature…”
Get full text

Parabens inhibit human skin estrogen sulfotransferase activity: Possible link to paraben estrogenic effects by Prusakiewicz, Jeffery J, Harville, Heather M, Zhang, Yanhua, Ackermann, Chrisita, Voorman, Richard L

“…Abstract Parabens ( p -hydroxybenzoate esters) are a group of widely used preservatives in topically applied cosmetic and pharmaceutical products. Parabens…”
Get full text

Conservative Secondary Shell Substitution In Cyclooxygenase‑2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics by Konkle, Mary E, Blobaum, Anna L, Moth, Christopher W, Prusakiewicz, Jeffery J, Xu, Shu, Ghebreselasie, Kebreab, Akingbade, Dapo, Jacobs, Aaron T, Rouzer, Carol A, Lybrand, Terry P, Marnett, Lawrence J

“…The cyclooxygenase enzymes (COX-1 and COX-2) are the therapeutic targets of nonsteroidal anti-inflammatory drugs (NSAIDs). Neutralization of the carboxylic…”
Get full text

High-performance liquid chromatography–tandem mass spectrometry assay of fatty acid amide hydrolase (FAAH) in blood: FAAH inhibition as clinical biomarker by Yapa, Udeni, Prusakiewicz, Jeffery J., Wrightstone, Ann D., Christine, Lori J., Palandra, Joe, Groeber, Elizabeth, Wittwer, Arthur J.

“…Fatty acid amide hydrolase (FAAH) is one of the main enzymes responsible for the degradation of the endocannabinoid anandamide (N-arachidonoylethanolamine,…”
Get full text

Oxidative metabolism of endocannabinoids by COX-2 by Kozak, Kevin R, Prusakiewicz, Jeffery J, Marnett, Lawrence J

“…The last decade has witnessed a rapid expansion in our understanding of the mammalian endogenous cannabinoid system. In just a few short years since the…”
Get more information

Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases by Prusakiewicz, Jeffery J., Turman, Melissa V., Vila, Andrew, Ball, Heather L., Al-Mestarihi, Ahmad H., Marzo, Vincenzo Di, Marnett, Lawrence J.

“…The lipoamino acids and endovanilloids have multiple roles in nociception, pain, and inflammation, yet their biological reactivity has not been fully…”
Get full text

Molecular Basis of the Time-Dependent Inhibition of Cyclooxygenases by Indomethacin by Prusakiewicz, Jeffery J, Felts, Andrew S, Mackenzie, Bonnie S, Marnett, Lawrence J

“…Cyclooxygenases (COXs) are the therapeutic targets of nonsteroidal antiinflammatory drugs. Indomethacin (INDO) was one of the first nonsteroidal…”
Get full text

Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2 by Prusakiewicz, Jeffery J., Kingsley, Philip J., Kozak, Kevin R., Marnett, Lawrence J.

“…Nonsteroidal anti-inflammatory drugs prevent hyperalgesia and inflammation by inhibiting the cyclooxygenase-2 (COX-2) catalyzed oxygenation of arachidonic acid…”
Get full text

Amino Acid Determinants in Cyclooxygenase-2 Oxygenation of the Endocannabinoid Anandamide by Kozak, Kevin R, Prusakiewicz, Jeffery J, Rowlinson, Scott W, Prudhomme, Daniel R, Marnett, Lawrence J

“…The endocannabinoid arachidonylethanolamide (AEA, anandamide) is an endogenous ligand for the cannabinoid receptors and has been shown to be oxygenated by…”
Get full text

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349 by Schneider, Claus, Boeglin, William E, Prusakiewicz, Jeffery J, Rowlinson, Scott W, Marnett, Lawrence J, Samel, Nigulas, Brash, Alan R

“…Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and…”
Get full text

Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms by Gupta, Rajnish A, Sarraf, Pasha, Mueller, Elisabetta, Brockman, Jeffrey A, Prusakiewicz, Jeffery J, Eng, Charis, Willson, Timothy M, DuBois, Raymond N

“…Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits cell growth and induces differentiation in…”
Get full text

Amino Acid Determinants in Cyclooxygenase-2 Oxygenation of the Endocannabinoid 2-Arachidonylglycerol by Kozak, Kevin R., Prusakiewicz, Jeffery J., Rowlinson, Scott W., Schneider, Claus, Marnett, Lawrence J.

“…The endocannabinoid, 2-arachidonylglycerol (2-AG), is an endogenous ligand for the central (CB1) and peripheral (CB2) cannabinoid receptors and has been shown…”
Get full text

The effect of 5-lipoxygenase inhibition on Aβ and inflammation in models of Alzheimer-like pathology by Wallace, Karin J, Campbell, Mary A, Prusakiewicz, Jeffery J, Caouette, David, Nolan, Charles E, Cadellina, Gregory W, Lu, Yifeng, Milici, Anthony J, Diane, Stephenson T, Bales, Kelly R, Roberds, Steven L, Dumin, Jo Ann

Get full text