Search Results - "Pruniau, Vincent"
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Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
Published in Cell metabolism (02-12-2014)“…The human growth hormone (hGH) minigene is frequently used in the derivation of transgenic mouse lines to enhance transgene expression. Although this minigene…”
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Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone
Published in PloS one (14-08-2015)“…The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a metabolic phenotype and reduced anxiety. Although several causes have been…”
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The AlfpCre mouse revisited: Evidence for liver steatosis related to growth hormone deficiency
Published in Hepatology (Baltimore, Md.) (01-12-2013)Get full text
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Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
Published in BioMed research international (01-01-2015)“…Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors,…”
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Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy
Published in The Journal of biological chemistry (20-09-2013)“…Streptozotocin (STZ) is widely used as diabetogenic agent in animal models for diabetic nephropathy (DN). However, it is also directly cytotoxic to kidneys,…”
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Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines
Published in European journal of cell biology (01-08-2017)“…•PC7 internalization requires a cluster of basic amino acids and two palmitoylated cysteines.•PC7 and Furin both recycle to the TGN via late endosomes.•Unlike…”
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The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone
Published in PloS one (15-10-2014)“…Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes,…”
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The Dwarf Phenotype in GH240B Mice, Haploinsufficient for the Autism Candidate Gene Neurobeachin, Is Caused by Ectopic Expression of Recombinant Human Growth Hormone: e109598
Published in PloS one (01-10-2014)“…Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes,…”
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