Search Results - "Pruitt, Hawley C."

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells by McCoy, Erin M, Hong, Huixian, Pruitt, Hawley C, Feng, Xu

“…Interleukin (IL)-11, a cytokine produced by breast cancer, has been implicated in breast cancer-induced osteolysis (bone destruction) but the mechanism(s) of…”
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Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy by Isser, Ariel, Silver, Aliyah B., Pruitt, Hawley C., Mass, Michal, Elias, Emma H., Aihara, Gohta, Kang, Si-Sim, Bachmann, Niklas, Chen, Ying-Yu, Leonard, Elissa K., Bieler, Joan G., Chaisawangwong, Worarat, Choy, Joseph, Shannon, Sydney R., Gerecht, Sharon, Weber, Jeffrey S., Spangler, Jamie B., Schneck, Jonathan P.

“…Helper (CD4 + ) T cells perform direct therapeutic functions and augment responses of cells such as cytotoxic (CD8 + ) T cells against a wide variety of…”
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Disruption of STAT5A and NMI signaling axis leads to ISG20-driven metastatic mammary tumors by Alsheikh, Heba Allah M., Metge, Brandon J., Pruitt, Hawley C., Kammerud, Sarah C., Chen, Dongquan, Wei, Shi, Shevde, Lalita A., Samant, Rajeev S.

“…Molecular dynamics of developmental processes are repurposed by cancer cells to support cancer initiation and progression. Disruption of the delicate balance…”
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Hypoxia re-programs 2′-O-Me modifications on ribosomal RNA by Metge, Brandon J., Kammerud, Sarah C., Pruitt, Hawley C., Shevde, Lalita A., Samant, Rajeev S.

“…Hypoxia is one of the critical stressors encountered by various cells of the human body under diverse pathophysiologic conditions including cancer and has…”
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Hydrogel Network Dynamics Regulate Vascular Morphogenesis by Wei, Zhao, Schnellmann, Rahel, Pruitt, Hawley C., Gerecht, Sharon

“…Matrix dynamics influence how individual cells develop into complex multicellular tissues. Here, we develop hydrogels with identical polymer components but…”
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Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes by Pruitt, Hawley C., Lewis, Daniel, Ciccaglione, Mark, Connor, Sydney, Smith, Quinton, Hickey, John W., Schneck, Jonathan P., Gerecht, Sharon

“…Lymphocyte motility is governed by a complex array of mechanisms, and highly dependent on external microenvironmental cues. Tertiary lymphoid sites in…”
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Engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy by Hickey, John W., Dong, Yi, Chung, Jae Wook, Salathe, Sebastian F., Pruitt, Hawley C., Li, Xiaowei, Chang, Calvin, Fraser, Andrew K., Bessell, Catherine A., Ewald, Andrew J., Gerecht, Sharon, Mao, Hai‐Quan, Schneck, Jonathan P.

“…T cell therapies require the removal and culture of T cells ex vivo to expand several thousand‐fold. However, these cells often lose the phenotype and…”
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Roles of N‐Myc and STAT interactor in cancer: From initiation to dissemination by Pruitt, Hawley C., Devine, Daniel J., Samant, Rajeev S.

“…N‐myc & STAT Interactor, NMI, is a protein that has mostly been studied for its physical interactions with transcription factors that play critical roles in…”
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Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis by Blatchley, Michael R, Hall, Franklyn, Wang, Songnan, Pruitt, Hawley C, Gerecht, Sharon

“…Vascular morphogenesis is the formation of endothelial lumenized networks. Cluster-based vasculogenesis of endothelial progenitor cells (EPCs) has been…”
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Collagen VI deposition mediates stromal T cell trapping through inhibition of T cell motility in the prostate tumor microenvironment by Pruitt, Hawley C., Guan, Ya, Liu, Hudson, Carey, Alexis E, Brennen, W. Nathaniel, Lu, Jiayun, Joshu, Corrine, Weeraratna, Ashani, Lotan, Tamara L., Karin Eisinger-Mathason, T.S., Gerecht, Sharon

“…•Collagen VI deposition correlates with higher T cell density in prostate cancer patients.•CD4+ T cell motility is ablated on Collagen VI due to a loss of…”
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Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment by Fuller, Ashley M, Pruitt, Hawley C, Liu, Ying, Irizarry-Negron, Valerie M, Pan, Hehai, Song, Hoogeun, DeVine, Ann, Katti, Rohan S, Devalaraja, Samir, Ciotti, Gabrielle E, Gonzalez, Michael V, Williams, Erik F, Murazzi, Ileana, Ntekoumes, Dimitris, Skuli, Nicolas, Hakonarson, Hakon, Zabransky, Daniel J, Trevino, Jose G, Weeraratna, Ashani, Weber, Kristy, Haldar, Malay, Fraietta, Joseph A, Gerecht, Sharon, Eisinger-Mathason, T S Karin

“…CD8+ T cell dysfunction impedes anti-tumor immunity in solid cancers but the underlying mechanisms are diverse and poorly understood. Extracellular matrix…”
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Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model by Goliwas, Kayla F., Richter, Jillian R., Pruitt, Hawley C., Araysi, Lita M., Anderson, Nicholas R., Samant, Rajeev S., Lobo-Ruppert, Susan M., Berry, Joel L., Frost, Andra R.

“…The use of in vitro , engineered surrogates in the field of cancer research is of interest for studies involving mechanisms of growth and metastasis, and…”
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Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors by Pruitt, Hawley C., Metge, Brandon J., Weeks, Shannon E., Chen, Dongquan, Wei, Shi, Kesterson, Robert A., Shevde, Lalita A., Samant, Rajeev S.

“…The process of organ development requires a delicate balance between cellular plasticity and differentiation. This balance is disrupted in cancer initiation…”
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microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer by Rostas, 3rd, Jack W, Pruitt, Hawley C, Metge, Brandon J, Mitra, Aparna, Bailey, Sarah K, Bae, Sejong, Singh, Karan P, Devine, Daniel J, Dyess, Donna L, Richards, William O, Tucker, J Allan, Shevde, Lalita A, Samant, Rajeev S

“…N-Myc Interactor is an inducible protein whose expression is compromised in advanced stage breast cancer. Downregulation of NMI, a gatekeeper of epithelial…”
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BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells by Graham, Christopher D, Kaza, Niroop, Pruitt, Hawley C, Gibson, Lauren M, Klocke, Barbara J, Shevde, Lalita A, Carroll, Steven L, Roth, Kevin A

“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, Schwann cell-derived neoplasms of the peripheral nervous system that have recently been shown…”
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Abstract 657: N-Myc and STAT Interactor knock out in the mammary epithelium prompts hyper-proliferation by Pruitt, Hawley C., Metge, Brandon J., Bailey, Sarah K., Shevde, Lalita A., Samant, Rajeev S.

“…Abstract N-Myc and STAT Interactor (NMI) is an evolutionarily conserved protein that is widely expressed in fetal and adult tissues. Early studies implicated…”
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Immunotherapy: Engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy (Adv. Mater. 23/2019) by Hickey, John W., Dong, Yi, Chung, Jae Wook, Salathe, Sebastian F., Pruitt, Hawley C., Li, Xiaowei, Chang, Calvin, Fraser, Andrew K., Bessell, Catherine A., Ewald, Andrew J., Gerecht, Sharon, Mao, Hai‐Quan, Schneck, Jonathan P.

“…In article number 1807359, Hai‐Quan Mao, Jonathan P. Schneck, and co‐workers introduce an artificial T‐cell stimulating matrix (aTM), a biomimetic…”
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Abstract A11: N-Myc and STAT interactor (NMI): A regulator of developmental signaling and EMT by Samant, Rajeev S., Pruitt, Hawley C., Metge, Brandon J., Shevde, Lalita A.

“…Abstract The NMI protein associates with known key transcription factors such as Myc and STATs and serves as a critical regulatory co-factor that dictates…”
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Abstract 4010: MicroRNA regulator of NMI: implications for breast cancer by Pruitt, Hawley C., III, Jack W. Rostas, Metge, Brandon J., Devine, Daniel J., Bailey, Sarah K., Shevde, Lalita A., Samant, Rajeev

“…Abstract Recent investigations by our laboratory have demonstrated that NMI expression is down-regulated in patient breast tumors, especially those displaying…”
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Abstract PR001: Oncogene-induced matrix reorganization controls CD8+ T cell immunity in the UPS microenvironment by Fuller, Ashley M., Pruitt, Hawley C., Song, Hoogeun, Liu, Ying, Devine, Ann, Katti, Rohan S., Devalaraja, Samir, Ciotti, Gabrielle E., Gonzalez, Michael, Williams, Erik F., Murazzi, Ileana, Skuli, Nicolas, Hakonarson, Hakon, Weber, Kristy, Haldar, Malay, Fraietta, Joseph A., Gerecht, Sharon, Eisinger-Mathason, T. S. Karin

“…Abstract CD8+ T cell dysfunction, characterized by reduced effector function, impaired proliferation, and inhibitory receptor upregulation, is a fundamental…”
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