Search Results - "Prueksaritanont, T"

Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A by Prueksaritanont, T, Tatosian, DA, Chu, X, Railkar, R, Evers, R, Chavez‐Eng, C, Lutz, R, Zeng, W, Yabut, J, Chan, GH, Cai, X, Latham, AH, Hehman, J, Stypinski, D, Brejda, J, Zhou, C, Thornton, B, Bateman, KP, Fraser, I, Stoch, SA

“…A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin, and atorvastatin has been established to allow simultaneous…”
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UGT2B17 Genetic Polymorphisms Dramatically Affect the Pharmacokinetics of MK-7246 in Healthy Subjects in a First-in-Human Study by Wang, Y-H, Trucksis, M, McElwee, J J, Wong, P H, Maciolek, C, Thompson, C D, Prueksaritanont, T, Garrett, G C, Declercq, R, Vets, E, Willson, K J, Smith, R C, Klappenbach, J A, Opiteck, G J, Tsou, J A, Gibson, C, Laethem, T, Panorchan, P, Iwamoto, M, Shaw, P M, Wagner, J A, Harrelson, J C

“…MK‐7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of respiratory diseases. In a…”
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Hepatic Metabolism of MK-0457, a Potent Aurora Kinase Inhibitor: Interspecies Comparison and Role of Human Cytochrome P450 and Flavin-Containing Monooxygenase by BALLARD, J. E, PRUEKSARITANONT, T, TANG, C

“…MK-0457 ( N -[4({4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1 H -pyrazol-5 -yl)amino]pyrimidin-2-yl}thio)phenyl]cyclopropanecarboxamide), an Aurora kinase…”
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Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport by Yamazaki, M., LI, B., Louie, S. W., Pudvah, N. T., Stocco, R., Wong, W., Abramovitz, M., Demartis, A., Laufer, R., Hochman, J. H., Prueksaritanont, T., Lin, J. H.

“…The effects of different fibric acid derivatives (bezafibrate, clofibrate, clofibric acid, fenofibrate, fenofibric acid and gemfibrozil) on human organic anion…”
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Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences by Roller, S., Cui, D., Laspina, C., Miller-Stein, C., Rowe, J., Wong, B., Prueksaritanont, T.

“…The underlying mechanism for low oral bioavailability of MK-0974, a potent calcitonin-gene related peptide (CGRP)-receptor antagonist, in monkeys and for…”
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Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells by Prueksaritanont, T, Gorham, L M, Hochman, J H, Tran, L O, Vyas, K P

“…Drug-metabolizing enzymes were studied in subcellular fractions of dog, monkey, and human small intestines, and in the human adenocarcinoma cell line Caco-2, a…”
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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction by Hebert, M F, Roberts, J P, Prueksaritanont, T, Benet, L Z

“…The pharmacokinetics of cyclosporine was studied in six healthy volunteers after administration of the drug orally (10 mg/kg) and intravenously (3 mg/kg) with…”
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Concurrent Administration of the Erythromycin Breath Test (EBT) and Oral Midazolam as In Vivo Probes for CYP3A Activity by McCrea, Jacqueline, Prueksaritanont, Thomayant, Gertz, Barry J., Carides, Alexandra, Gillen, Lisa, Antonello, Suzanne, Brucker, Mary Jo, Miller-Stein, Cynthia, Osborne, Barbara, Waldman, S.

“…Given the prominent role of CYP3A in the metabolism of drugs, it is important to identify whether new chemical entities will affect this enzyme system and…”
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Interactions between Simvastatin and Troglitazone or Pioglitazone in Healthy Subjects by Prueksaritanont, Thomayant, Vega, José M., Zhao, Jamie, Gagliano, Kathleen, Kuznetsova, Olga, Musser, Bret, Amin, Raju D., Liu, Lida, Roadcap, Brad A., Dilzer, Stacy, Lasseter, K. C., Rogers, J. Douglas

“…Two randomized, two‐period crossover studies were conducted to evaluate the effects of repeat oral dosing of troglitazone (Study I) and pioglitazone (Study II)…”
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Stereoselective hepatic disposition of a diastereomeric pair of αvβ3 antagonists in rat by Prueksaritanont, T., Xu, X., Deluna, P., Yamazaki, M., Lin, J. H.

“…1. The study investigated mechanisms underlying the stereoselective hepatic disposition observed in rats of a zwitterionic diastereomeric pair ((3S)-3-{(3R or…”
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Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective by Prueksaritanont, Thomayant, Chu, Xiaoyan, Gibson, Christopher, Cui, Donghui, Yee, Ka Lai, Ballard, Jeanine, Cabalu, Tamara, Hochman, Jerome

“…Recently, the US Food and Drug Administration and European Medicines Agency have issued new guidance for industry on drug interaction studies, which outline…”
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Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist by Prueksaritanont, T, Lu, P, Gorham, L, Sternfeld, F, Vyas, K P

“…1. Quantitative species differences and human liver enzymes involved in the metabolism of L-775,606, a potent and selective 5-HT1D receptor agonist developed…”
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An extended point-area deconvolution approach for assessing drug input rates by YEH, Kuang C, HOLDER, Daniel J, WINCHELL, Gregory A, WENNING, Larissa A, PRUEKSARITANONT, Thomayant

“…To describe an extended point-area deconvolution approach for evaluating drug input rates based on the application of piecewise cubic polynomial functions…”
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Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of αvβ3-antagonists in rat: limited role of P-glycoprotein by PRUEKSARITANONT, T, MENG, Y, LIN, J. H, MA, B, LEPPERT, P, HOCHMAN, J, TANG, C, PERKINS, J, ZRADA, M, MEISSNER, R, DUGGAN, M. E

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Simvastatin Does Not Affect CYP3A Activity, Quantified by the Erythromycin Breath Test and Oral Midazolam Pharmacokinetics, in Healthy Male Subjects by Prueksaritanont, Thomayant, Vega, José M., Rogers, J. Douglas, Gagliano, Kathleen, Greenberg, Howard E., Gillen, Lisa, Brucker, Mary Jo, McLoughlin, Debra, Wong, Peggy H., Waldman, Scott A.

“…Potential for inhibition of CYP3A activity by simvastatin, an HMG‐CoA reductase inhibitor, was evaluated in 12 healthy male subjects who received placebo or 80…”
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Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A by Prueksaritanont, T, Correia, M A, Rettie, A E, Swinney, D C, Thomas, P E, Benet, L Z

“…Cyclosporine (CyA) metabolism was investigated in liver microsomes obtained from untreated male and female Sprague-Dawley rats, and rats pretreated with…”
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The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6 by Prueksaritanont, Thomayant, Ma, Bennett, Yu, Nathan

“…Aims  To identify the cytochrome P450 (CYP) isoforms responsible for the metabolism of simvastatin hydroxy acid (SVA), the most potent metabolite of…”
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Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT1D receptor agonist by PRUEKSARITANONT, T, LU, P, GORHAM, L, STERNFELD, F, VYAS, K. P

“…1. Quantitative species differences and human liver enzymes involved in the metabolism of L-775,606, a potent and selective 5-HT1D receptor agonist developed…”
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FK 506 metabolism in male and female rat liver microsomes by Perotti, B Y, Okudaira, N, Prueksaritanont, T, Benet, L Z

“…The main metabolite of the immunosuppressant FK 506 in hepatic microsomes from male and female Sprague-Dawley rats was identified by mass spectrometry as an…”
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Effects of Fibrates on Metabolism of Statins in Human Hepatocytes by PRUEKSARITANONT, Thomayant, CUYUE TANG, YUE QIU, MU, Lillian, SUBRAMANIAN, Raju, LIN, Jiunn H

“…This study investigated the metabolic interaction between fibrates and statin hydroxy acids in human hepatocytes. Gemfibrozil (GFZ) modestly affected the…”
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