Search Results - "Prudner, Bethany"

Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives by Prudner, Bethany C, Ball, Tyler, Rathore, Richa, Hirbe, Angela C

“…One of the most common malignancies affecting adults with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the malignant peripheral nerve…”
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SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma by Bill, Kate Lynn J, Garnett, Jeannine, Meaux, Isabelle, Ma, XiaoYen, Creighton, Chad J, Bolshakov, Svetlana, Barriere, Cedric, Debussche, Laurent, Lazar, Alexander J, Prudner, Bethany C, Casadei, Lucia, Braggio, Danielle, Lopez, Gonzalo, Zewdu, Abbie, Bid, Hemant, Lev, Dina, Pollock, Raphael E

“…Dedifferentiated liposarcoma (DDLPS) is an aggressive malignancy that can recur locally or disseminate even after multidisciplinary care. Genetically amplified…”
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Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors by Prudner, Bethany C, Rathore, Richa, Robinson, Anthony M, Godec, Abigail, Chang, Samuel F, Hawkins, William G, Hirbe, Angela C, Van Tine, Brian A

“…The response to acute and long-term arginine starvation results in a conditional adaptive metabolic reprogramming that can be harnessed for therapeutic…”
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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma by Rathore, Richa, Caldwell, Katharine E., Schutt, Charles, Brashears, Caitlyn B., Prudner, Bethany C., Ehrhardt, William R., Leung, Cheuk Hong, Lin, Heather, Daw, Najat C., Beird, Hannah C., Giles, Abigail, Wang, Wei-Lien, Lazar, Alexander J., Chrisinger, John S.A., Livingston, J. Andrew, Van Tine, Brian A.

“…Osteosarcoma is the most common pediatric and adult primary malignant bone cancer. Curative regimens target the folate pathway, downstream of serine…”
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Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress by Takchi, Rony, Prudner, Bethany C., Gong, Qingqing, Hagi, Takaomi, Newcomer, Kenneth F., Jin, Linda X., Vangveravong, Suwanna, Van Tine, Brian A., Hawkins, William G., Spitzer, Dirk

“…Sigma-2-ligands (S2L) are characterized by high binding affinities to their cognate sigma-2 receptor, overexpressed in rapidly proliferating tumor cells. As…”
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Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102 by Brashears, Caitlyn B, Prudner, Bethany C, Rathore, Richa, Caldwell, Katharine E, Dehner, Carina A, Buchanan, Jane L, Lange, Sara E S, Poulin, Neal, Sehn, Jennifer K, Roszik, Jason, Spitzer, Dirk, Jones, Kevin B, O'Keefe, Regis, Nielsen, Torsten O, Taylor, Eric B, Held, Jason M, Hawkins, William, Van Tine, Brian A

“…To investigate the metabolism of synovial sarcoma (SS) and elucidate the effect of malic enzyme 1 absence on SS redox homeostasis. ME1 expression was measured…”
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Liposarcoma: molecular targets and therapeutic implications by Bill, Kate Lynn J., Casadei, Lucia, Prudner, Bethany C., Iwenofu, Hans, Strohecker, Anne M., Pollock, Raphael E.

“…Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery,…”
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Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma by Bill, Kate Lynn J, Garnett, Jeannine, Meaux, Isabelle, Ma, XiaoYen, Creighton, Chad J, Bolshakov, Svetlana, Barriere, Cedric, Debussche, Laurent, Lazar, Alexander J, Prudner, Bethany C, Casadei, Lucia, Braggio, Danielle, Lopez, Gonzalo, Zewdu, Abbie, Bid, Hemant, Dina, Lev, Pollock, Raphael E

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A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas by Bean, Gregory R, Kremer, Jeff C, Prudner, Bethany C, Schenone, Aaron D, Yao, Juo-Chin, Schultze, Matthew B, Chen, David Y, Tanas, Munir R, Adkins, Douglas R, Bomalaski, John, Rubin, Brian P, Michel, Loren S, Van Tine, Brian A

“…Sarcomas comprise a large heterogeneous group of mesenchymal cancers with limited therapeutic options. When treated with standard cytotoxic chemotherapies,…”
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HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST) by Lopez, Gonzalo, Bill, Kate Lynn J, Bid, Hemant Kumar, Braggio, Danielle, Constantino, Dylan, Prudner, Bethany, Zewdu, Abeba, Batte, Kara, Lev, Dina, Pollock, Raphael E

“…HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses…”
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Yoga Therapy During Chemotherapy for Early-Stage and Locally Advanced Breast Cancer by Greaney, Samantha K., Amin, Neha, Prudner, Bethany C., Compernolle, Maggie, Sandell, Linda J., Tebb, Susan C., Weilbaecher, Katherine N., Abeln, Peri, Luo, Jingqin, Tao, Yu, Hirbe, Angela C., Peterson, Lindsay L.

“…Background: Chemotherapy is associated with decreased quality of life (QOL), fatigue, depression, and weight gain in patients with breast cancer. Weight gain…”
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α-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin by Prudner, Bethany C., Roy, Pritam Sinha, Damron, Derek S., Russell, Mary A.

“…•The 312 amino acid insert unique to α-synemin interacts with the M10 domain of titin.•Endogenous α-synemin and titin co-immunoprecipitate from HL-1…”
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miR-133a function in the pathogenesis of dedifferentiated liposarcoma by Yu, Peter Y, Lopez, Gonzalo, Braggio, Danielle, Koller, David, Bill, Kate Lynn J, Prudner, Bethany C, Zewdu, Abbie, Chen, James L, Iwenofu, O Hans, Lev, Dina, Strohecker, Anne M, Fenger, Joelle M, Pollock, Raphael E, Guttridge, Denis C

“…Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis…”
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Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers by Kremer, Jeff Charles, Prudner, Bethany Cheree, Lange, Sara Elaine Stubbs, Bean, Gregory Richard, Schultze, Matthew Bailey, Brashears, Caitlyn Brook, Radyk, Megan DeAnna, Redlich, Nathan, Tzeng, Shin-Cheng, Kami, Kenjiro, Shelton, Laura, Li, Aixiao, Morgan, Zack, Bomalaski, John Stephen, Tsukamoto, Takashi, McConathy, Jon, Michel, Loren Scott, Held, Jason Matthew, Van Tine, Brian Andrew

“…Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate…”
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P1134: BISPECIFIC ANTI‐CD20/19 CAR‐T – ZAMTOCABTAGENE AUTOLEUCEL FOR RELAPSED/REFRACTORY DLBCL – INTERIM ANALYSIS RESULTS OF DALY‐II‐USA STUDY by Shah, Nirav, Maziarz, Richard, Jacobson, Caron, Isufi, Iris, Ghosh, Monalisa, Ulrickson, Matthew, Perales, Miguel‐Angel, Lunning, Matthew, Hardy, Nancy, Wijatyk, Anna, Ancukiewicz, Marek, Nallewar, Madhavi, Coleman, Kimberly, Prudner, Bethany, Eromosele, Esther, Kaleta, Remigiusz, Miklos, David

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p67/MetAP2 Suppresses K-RasV12-Mediated Transformation of NIH3T3 Mouse Fibroblasts in Culture and in Athymic Mice by Majumdar, Avijit, Ghosh, Arnab, Datta, Samit, Prudner, Bethany C, Datta, Bansidhar

“…In many tumor cells, the activation and activity of extracellular signal-regulated kinases (ERK1/2) are very high because of the constitutive activation of the…”
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Propofol restores TRPV1 sensitivity via a TRPA1‐, nitric oxide synthase‐dependent activation of PKCε by Sinharoy, Pritam, Zhang, Hongyu, Sinha, Sayantani, Prudner, Bethany C., Bratz, Ian N., Damron, Derek S.

“…We previously demonstrated that the intravenous anesthetic, propofol, restores the sensitivity of transient receptor potential vanilloid channel subtype‐1…”
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Propofol restores TRPV 1 sensitivity via a TRPA 1‐, nitric oxide synthase‐dependent activation of PKC ε by Sinharoy, Pritam, Zhang, Hongyu, Sinha, Sayantani, Prudner, Bethany C., Bratz, Ian N., Damron, Derek S.

“…We previously demonstrated that the intravenous anesthetic, propofol, restores the sensitivity of transient receptor potential vanilloid channel subtype‐1 (…”
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The A‐kinase anchoring protein b‐synemin binds PKCe by Russell, Mary, Prudner, Bethany, Kuneli, Melissa, Damron, Derek, Chen, Yijing

“…Synemin is a type IV intermediate filament (IF) protein. The two largest isoforms (α and β) are co‐expressed in a variety of cell types including muscle cells…”
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Abstract CT111: Preclinical justification for the Phase II clinical trial ADI-PEG 20 in combination with gemcitabine and docetaxel for the treatment of soft tissue sarcoma by Prudner, Bethany C., Rathore, Richa, Godec, Abigail, Chang, Samuel F., Hirbe, Angela, Tine, Brian A. Van

“…The response to acute and long-term arginine starvation results in an adaptive metabolic reprogramming that can be harnessed for therapeutic opportunities in…”
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