Search Results - "Prudkin, Ludmila"

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients by Scaltriti, Maurizio, Eichhorn, Pieter J, Cortés, Javier, Prudkin, Ludmila, Aura, Claudia, Jiménez, José, Chandarlapaty, Sarat, Serra, Violeta, Prat, Aleix, Ibrahim, Yasir H, Guzmán, Marta, Gili, Magui, Rodríguez, Olga, Rodríguez, Sonia, Pérez, José, Green, Simon R, Mai, Sabine, Rosen, Neal, Hudis, Clifford, Baselga, José

“…Clinical benefits from trastuzumab and other anti-HER2 therapies in patients with HER2 amplified breast cancer remain limited by primary or acquired…”
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RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer by Serra, Violeta, Eichhorn, Pieter J A, García-García, Celina, Ibrahim, Yasir H, Prudkin, Ludmila, Sánchez, Gertrudis, Rodríguez, Olga, Antón, Pilar, Parra, Josep-Lluís, Marlow, Sara, Scaltriti, Maurizio, Pérez-Garcia, José, Prat, Aleix, Arribas, Joaquín, Hahn, William C, Kim, So Young, Baselga, José

“…The PI3K signaling pathway regulates diverse cellular processes, including proliferation, survival, and metabolism, and is aberrantly activated in human…”
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miR-93, miR-98, and miR-197 Regulate Expression of Tumor Suppressor Gene FUS1 by Du, Liqin, Schageman, Jeoffrey J, Subauste, Maria C, Saber, Barbara, Hammond, Scott M, Prudkin, Ludmila, Wistuba, Ignacio I, Ji, Lin, Roth, Jack A, Minna, John D, Pertsemlidis, Alexander

“…FUS1 is a tumor suppressor gene located on human chromosome 3p21, and expression of Fus1 protein is highly regulated at various levels, leading to lost or…”
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Immunohistochemical Expression of Estrogen and Progesterone Receptors Identifies a Subset of NSCLCs and Correlates with EGFR Mutation by RASO, Maria G, BEHRENS, Carmen, LEE, J. Jack, WISTUBA, Ignacio I, HERYNK, Matthew H, SUYU LIU, PRUDKIN, Ludmila, OZBURN, Natalie C, WOODS, Denise M, XIMING TANG, MEHRAN, Reza J, MORAN, Cesar

“…Purpose: To determine the frequency of estrogen receptor α and β and progesterone receptor protein immunohistochemical expression in a large set of non–small…”
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Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung by Prudkin, Ludmila, Liu, Diane D, Ozburn, Natalie C, Sun, Menghong, Behrens, Carmen, Tang, Ximing, Brown, Kathlynn C, Bekele, B Nebiyou, Moran, Cesar, Wistuba, Ignacio I

“…Epithelial-to-mesenchymal transition is a process in which cells undergo a developmental switch from an epithelial to a mesenchymal phenotype. We investigated…”
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Expression of the Receptor Tyrosine Kinase EphA2 Is Increased in Smokers and Predicts Poor Survival in Non–Small Cell Lung Cancer by BRANNAN, Jennifer M, WENLI DONG, PRUDKIN, Ludmila, BEHRENS, Carmen, LOTAN, Reuben, NEBIYOU BEKELE, B, WISTUBA, Ignacio, JOHNSON, Faye M

“…Purpose: Up-regulation of the receptor tyrosine kinase EphA2 has been shown in several epithelial cancers. Epidermal growth factor receptor (EGFR) and K-Ras…”
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Epidermal growth factor receptor and K‐Ras mutations and resistance of lung cancer to insulin‐like growth factor 1 receptor tyrosine kinase inhibitors by Kim, Woo‐Young, Prudkin, Ludmila, Feng, Lei, Kim, Edward S., Hennessy, Bryan, Lee, Ju‐Seog, Lee, J. Jack, Glisson, Bonnie, Lippman, Scott M., Wistuba, Ignacio I., Hong, Waun Ki, Lee, Ho‐Young

“…BACKGROUND: Most patients with nonsmall cell lung cancer (NSCLC) have responded poorly to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors…”
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Germ-line and somatic presentations of the EGFR T790M mutation in lung cancer by Prudkin, Ludmila, Tang, Ximing, Wistuba, Ignacio I

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Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer by Scaltriti, Maurizio, Serra, Violeta, Normant, Emmanuel, Guzman, Marta, Rodriguez, Olga, Lim, Alice R, Slocum, Kelly L, West, Kip A, Rodriguez, Varenka, Prudkin, Ludmila, Jimenez, José, Aura, Claudia, Baselga, José

“…Hsp90 facilitates the maturation and stability of numerous oncoproteins, including HER2. The aim of this study was to assess the antitumor activity of the…”
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Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development by KIM, Woo-Young, QUANRI JIN, LEE, J. Jack, LIPPMAN, Scott M, WAUN KI HONG, WISTUBA, Ignacio I, LEE, Ho-Young, OH, Seung-Hyun, KIM, Edward S, YOUN JOO YANG, DONG HOON LEE, LEI FENG, BEHRENS, Carmen, PRUDKIN, Ludmila, MILLER, York E

“…Insulin-like growth factor (IGF)-I receptor (IGF-IR) signaling has been implicated in several human neoplasms. However, the role of serum levels of IGFs in…”
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EphA2 in the early pathogenesis and progression of non-small cell lung cancer by Brannan, Jennifer M, Sen, Banibrata, Saigal, Babita, Prudkin, Ludmila, Behrens, Carmen, Solis, Luisa, Dong, Wenli, Bekele, B Nebiyou, Wistuba, Ignacio, Johnson, Faye M

“…Overexpression of the receptor tyrosine kinase EphA2 occurs in non-small cell lung cancer (NSCLC) and a number of other human cancers. This overexpression…”
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Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer by PRUDKIN, Ludmila, BEHRENS, Carmen, WISTUBA, Ignacio I, LIU, Diane D, XIAN ZHOU, OZBURN, Natalie C, NEBIYOU BEKELE, B, MINNA, John D, MORAN, Cesar, ROTH, Jack A, LIN JI

“…Purpose: FUS1 , a novel tumor-suppressor gene located in the chromosome 3p21.3 region, may play an important role in lung cancer development. Currently, FUS1…”
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Sunscreens prescribed to patients with skin of color and/or with melasma: A survey of 221 dermatologists and dermatology residents in Spain by Morgado‐Carrasco, Daniel, Delgado, Jesús, Prudkin‐Silva, Ludmila, Santamaria, Júlia, Piquero‐Casals, Jaime

“…Background Dark‐skinned individuals (DSI) present high rates of melasma and post‐inflammatory hyperpigmentation. The use of sunscreens with mineral filters is…”
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PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer by Majewski, Ian J, Nuciforo, Paolo, Mittempergher, Lorenza, Bosma, Astrid J, Eidtmann, Holger, Holmes, Eileen, Sotiriou, Christos, Fumagalli, Debora, Jimenez, Jose, Aura, Claudia, Prudkin, Ludmila, Díaz-Delgado, Maria Carmen, de la Peña, Lorena, Loi, Sherene, Ellis, Catherine, Schultz, Nikolaus, de Azambuja, Evandro, Harbeck, Nadia, Piccart-Gebhart, Martine, Bernards, René, Baselga, José

“…We investigated whether mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) correlates with response to…”
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The exposome impact on hair health: etiology, pathogenesis and clinical features ‒ Part I by Cedirian, Stephano, Prudkin, Ludmila, Piraccini, Bianca Maria, Santamaria, Julia, Piquero-Casals, Jaime, Saceda-Corralo, David

“…Human hair, particularly on the scalp, serves as a significant aspect of social identity and well-being. The exposome, encompassing both intrinsic and…”
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Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic by Prudkin, Ludmila, Nuciforo, Paolo

“…Background Tailoring treatment strategies to individual patients requires the availability of reliable biomarkers. Despite important investment in biomarker…”
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TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma by Anido, Judit, Sáez-Borderías, Andrea, Gonzàlez-Juncà, Alba, Rodón, Laura, Folch, Gerard, Carmona, Maria A, Prieto-Sánchez, Rosa M, Barba, Ignasi, Martínez-Sáez, Elena, Prudkin, Ludmila, Cuartas, Isabel, Raventós, Carolina, Martínez-Ricarte, Francisco, Poca, M Antonia, García-Dorado, David, Lahn, Michael M, Yingling, Jonathan M, Rodón, Jordi, Sahuquillo, Juan, Baselga, José, Seoane, Joan

“…Glioma-initiating cells (GICs), also called glioma stem cells, are responsible for tumor initiation, relapse, and therapeutic resistance. Here, we show that…”
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Exposome Impact on Nail Health by Prudkin, Ludmila, Cedirian, Stephano, Santamaria, Júlia, Jourdan, Eric, Piraccini, Bianca Maria

“…Abstract Background: The nail unit is a complex system with various components, each serving distinct functions. The exposome, encompassing external and…”
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High HER2 expression correlates with response to the combination of lapatinib and trastuzumab by Scaltriti, Maurizio, Nuciforo, Paolo, Bradbury, Ian, Sperinde, Jeff, Agbor-Tarh, Dominique, Campbell, Christine, Chenna, Ahmed, Winslow, John, Serra, Violeta, Parra, Josep Lluis, Prudkin, Ludmila, Jimenez, José, Aura, Claudia, Harbeck, Nadia, Pusztai, Lajos, Ellis, Catherine, Eidtmann, Holger, Arribas, Joaquin, Cortes, Javier, de Azambuja, Evandro, Piccart, Martine, Baselga, José

“…Expression of p95HER2 has been associated with resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Conversely, high levels of…”
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Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials by Dienstmann, Rodrigo, Serpico, Danila, Rodon, Jordi, Saura, Cristina, Macarulla, Teresa, Elez, Elena, Alsina, Maria, Capdevila, Jaume, Perez-Garcia, Jose, Sánchez-Ollé, Gessamí, Aura, Claudia, Prudkin, Ludmila, Landolfi, Stefania, Hernández-Losa, Javier, Vivancos, Ana, Tabernero, Josep

“…Clinical experience increasingly suggests that molecular prescreening and biomarker enrichment strategies in phase I trials with targeted therapies will…”
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