Search Results - "Prud'homme, J"

Cancer stem cells and novel targets for antitumor strategies by Prud'homme, Gérald J

“…Cancer stem cells (CSCs) were identified in human leukemias in landmark studies of John Dick and his colleagues. Subsequently, similar cancer stem-like cells…”
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Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity by Glinka, Yelena, Prud'homme, Gérald J.

“…Neuropilin‐1 (Nrp1) is a multifunctional protein, identified principally as a receptor for the class 3 semaphorins and members of the vascular endothelial…”
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Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations by Prud'homme, Gérald J

“…Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer…”
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GABA Protects Human Islet Cells Against the Deleterious Effects of Immunosuppressive Drugs and Exerts Immunoinhibitory Effects Alone by Prud’homme, Gérald J, Glinka, Yelena, Hasilo, Craig, Paraskevas, Steven, Li, Xiaoming, Wang, Qinghua

“…BACKGROUNDWe recently found that γ-aminobutyric acid (GABA) protects mouse islet β cells. It prevented autoimmune type 1 diabetes in mice, induced islet β-cell…”
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Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist by Prud'homme, Gérald J, Glinka, Yelena, Toulina, Anna, Ace, Olga, Subramaniam, Venkateswaran, Jothy, Serge

“…Cancer stem cells (CSCs) have increased resistance to cancer chemotherapy. They can be enriched as drug-surviving CSCs (D-CSCs) by growth with chemotherapeutic…”
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Immunological GABAergic interactions and therapeutic applications in autoimmune diseases by Prud'homme, Gérald J, Glinka, Yelena, Wang, Qinghua

“…Abstract Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. However, it is also produced in other sites; notably by…”
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Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta by GLINKA, Yelena, STOILOVA, Snejana, MOHAMMED, Nada, PRUD'HOMME, Gérald J

“…Neuropilin (Nrp)-1 and Nrp-2 are multifunctional proteins frequently expressed by cancer cells and contribute to tumor progression by mechanisms that are not…”
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GABAergic regulation of pancreatic islet cells: Physiology and antidiabetic effects by Wang, Qinghua, Ren, Liwei, Wan, Yun, Prud'homme, Gerald J.

“…Diabetes occurs when pancreatic β‐cell death exceeds β‐cell growth, which leads to loss of β‐cell mass. An effective therapy must have two actions: promotion…”
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GABA requires GLP-1R to exert its pancreatic function during STZ challenge by Shao, Weijuan, Liu, Wenjuan, Liang, Ping, Song, Zhuolun, Israel, Odisho, Prud’homme, Gerald J, Wang, Qinghua, Jin, Tianru

“…Gamma-aminobutyric acid (GABA) administration attenuates streptozotocin (STZ)-induced diabetes in rodent models with unclear underlying mechanisms. We found…”
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Combined use of GABA and sitagliptin promotes human β-cell proliferation and reduces apoptosis by Liu, Wenjuan, Lau, Harry Kevin, Son, Dong Ok, Jin, Tianru, Yang, Yehong, Zhang, Zhaoyun, Li, Yiming, Prud’homme, Gerald J, Wang, Qinghua

“…γ-Aminobutyric acid (GABA) and glucagon-like peptide-1 receptor agonist (GLP-1RA) improve rodent β-cell survival and function. In human β-cells, GABA exerts…”
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Causal effects of non-alcoholic fatty liver disease on osteoporosis: a Mendelian randomization study by Zhou, Yue, Ni, Yunzhi, Wang, Zhihong, Prud'homme, Gerald J, Wang, Qinghua

“…Osteoporosis (OP) is a systemic skeletal disease characterized by compromised bone strength leading to an increased risk of fracture. There is an ongoing…”
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GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes by Soltani, Nepton, Qiu, Hongmin, Aleksic, Mila, Glinka, Yelena, Zhao, Fang, Liu, Rui, Li, Yiming, Zhang, Nina, Chakrabarti, Rabindranath, Ng, Tiffany, Jin, Tianru, Zhang, Haibo, Lu, Wei-Yang, Feng, Zhong-Ping, Prud'homme, Gerald J, Wang, Qinghua

“…Type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and islet β-cell loss. Thus, an effective therapy may require β-cell restoration…”
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Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity by Prud'homme, Gérald J, Glinka, Yelena

“…The neuropilins (Nrps) are multifunctional proteins involved in development, immunity and cancer. Neuropilin-1 (Nrp1), or its homologue neuropilin-2 (Nrp2),…”
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GABA promotes human β-cell proliferation and modulates glucose homeostasis by Purwana, Indri, Zheng, Juan, Li, Xiaoming, Deurloo, Marielle, Son, Dong Ok, Zhang, Zhaoyun, Liang, Christie, Shen, Eddie, Tadkase, Akshaya, Feng, Zhong-Ping, Li, Yiming, Hasilo, Craig, Paraskevas, Steven, Bortell, Rita, Greiner, Dale L, Atkinson, Mark, Prud'homme, Gerald J, Wang, Qinghua

“…γ-Aminobutyric acid (GABA) exerts protective and regenerative effects on mouse islet β-cells. However, in humans it is unknown whether it can increase β-cell…”
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CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia by Ma, Li, Simpson, Elisa, Li, June, Xuan, Min, Xu, Miao, Baker, Laura, Shi, Yan, Yougbaré, Issaka, Wang, Xiaozhong, Zhu, Guangheng, Chen, Pingguo, Prud'homme, Gerald J., Lazarus, Alan H., Freedman, John, Ni, Heyu

“…Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder characterized by autoantibodies targeting platelet surface proteins, most commonly…”
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Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function by Prud'homme, Gerald J, Glinka, Yelena, Lichner, Zsuzsanna, Yousef, George M

“…Extracellular miRNAs are increasingly studied as markers for specific diseases. They are released in biological fluids in a remarkably stable form, and may…”
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Impacts on human mortality due to reductions in PM10 concentrations through different traffic scenarios in Paris, France by Maesano, C.N., Morel, G., Matynia, A., Ratsombath, N., Bonnety, J., Legros, G., Da Costa, P., Prud'homme, J., Annesi-Maesano, I.

“…Air pollution is a well-known burden for population health and health systems worldwide. Reduction in air pollution is associated with improvements in…”
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Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice by Liu, Wenjuan, Son, Dong Ok, Lau, Harry K, Zhou, Yinghui, Prud'homme, Gerald J, Jin, Tianru, Wang, Qinghua

“…γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell…”
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The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells by Prud'homme, Gérald J., Glinka, Yelena, Kurt, Merve, Liu, Wenjuan, Wang, Qinghua

“…Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes (T1D), by suppressing autoimmune responses and stimulating pancreatic…”
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DNA vaccination against tumors by Prud'homme, Gérald J.

“…DNA vaccines have been used to generate protective immunity against tumors in a variety of experimental models. The favorite target antigens have been those…”
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