Search Results - "Prud'homme, GJ"

DNA vaccination against tumors by Prud'homme, Gérald J.

“…DNA vaccines have been used to generate protective immunity against tumors in a variety of experimental models. The favorite target antigens have been those…”
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Clonal deletion and autoreactivity in extrathymic CD4-CD8-(double negative) T cell receptor-alpha/beta T cells by Prud'Homme, GJ, Bocarro, DC, Luke, EC

“…Peripheral CD4-CD8- (double negative) T cells (DNT cells) that express TCR-alpha/beta (DNT-alpha/beta cells) are expanded in some autoimmunity-prone mice, but…”
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The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases by Prud'homme, Gérald J, Piccirillo, Ciriaco A

“…The importance of transforming growth factor-beta-1 (TGF-β1) in immunoregulation and tolerance has been increasingly recognized. It is now proposed that there…”
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Factors influencing the development of visual loss in advanced diabetic retinopathy. Diabetic Retinopathy Study (DRS) Report No. 10 by Rand, LI, Prud'homme, GJ, Ederer, F, Canner, PL

“…Natural history data from the Diabetic Retinopathy Study were examined by multivariate methods to determine which baseline characteristics could predict the…”
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Treatment of murine lupus with cDNA encoding IFN-γR/Fc by Lawson, Brian R., Prud’homme, Gerald J., Chang, Yigang, Gardner, Humphrey A., Kuan, Jason, Kono, Dwight H., Theofilopoulos, Argyrios N.

“…IFN-γ, a pleiotropic cytokine, is a key effector molecule in the pathogenesis of several autoimmune diseases, including lupus. Importantly, deletion of IFN-γ…”
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TGF- beta 1 Somatic Gene Therapy Prevents Autoimmune Disease in Nonobese Diabetic Mice by Piccirillo, CA, Chang, Y, Prud'homme, G J

“…Nonobese diabetic (NOD) mice develop insulitis and diabetes through an autoimmune process. Since TGF- beta 1 down-regulates many immune responses, we…”
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Immunopathology and the gene therapy of lupus by Mageed, R A, Prud'homme, G J

“…Lupus is a chronic autoimmune inflammatory disease with complex clinical manifestations. In humans, lupus, also known as systemic lupus erythematosus (SLE),…”
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Patterns of MHC antigenic modulation in cyclosporine-induced autoimmunity. Implications for pathogenesis by Parfrey, NA, Prud'homme, GJ

“…To explore the role of aberrant MHC expression in the pathogenesis of cyclosporine-induced autoimmunity (CSIA), we examined the patterns of major…”
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The Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Suppress Macrophage Activation and Nitric Oxide Production in Vitro and in Vivo by Beshay, Evette, Croze, France, Prud'homme, Gérald J.

“…We studied the effects of the phosphodiesterase inhibitors pentoxifylline (PTX) and rolipram (ROL) on nitric oxide (NO) production by macrophages and…”
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Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors by Prud'homme, Gérald J.

“…Gene therapy offers advantages for the immunotherapeutic delivery of cytokines or their inhibitors. After gene transfer, these mediators are produced at…”
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Altering immune tolerance therapeutically: the power of negative thinking by Gérald J. Prud’homme

“…The etiology of most human autoimmune diseases remains largely unknown. However, investigators have identified several negative regulatory mechanisms acting at…”
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Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA) by Chakrabarti, Rabindranath, Chang, Yigang, Song, Keli, Prud’homme, Gerald J.

“…Vaccination with plasmids encoding an antigen of interest (DNA vaccination) is a new strategy to achieve effective immunization against many agents. DNA…”
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Regulation of T-helper-1 versus T-helper-2 activity and enhancement of tumor immunity by combined DNA-based vaccination and nonviral cytokine gene transfer by SONG, K, CHANG, Y, PRUD'HOMME, G. J

“…Intramuscular (i.m.) injections of a plasmid encoding human carcinoembryonic antigen (CEA) elicited both humoral and cellular immune responses in mice, but…”
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Immunoinhibitory DNA vaccine protects against autoimmune diabetes through cDNA encoding a selective CTLA-4 (CD152) ligand by Prud'homme, Gerald J, Chang, Yigang, Li, Xiaoying

“…Cytotoxic T lymphocyte antigen 4 (CTLA-4 or CD152) is a strong negative regulator of T cell activity. Like CD28 (a positive regulator) it binds to B7-1 and…”
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Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein by PRUD'HOMME, G. J, CHANG, Y

“…We report on long-term delivery of an interferon-gamma (IFN gamma) inhibitory protein by intramuscular (i.m.) gene therapy. IFN gamma is a cytokine that plays…”
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Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes by Croze, France, Prud'homme, Gérald J.

“…Background Despite improvements in insulin preparation and delivery, physiological normoglycemia is not easily achieved in diabetics. Therefore, there has been…”
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Immunotherapeutic gene transfer into muscle by Prud'homme, Gérald J, Lawson, Brian R, Chang, Yigang, Theofilopoulos, Argyrios N

“…Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be…”
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IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice by Song, K, Chang, Y, Prud'homme, G J

“…Intramuscular (i.m.) injection of a plasmid encoding human carcinoembryonic antigen (CEA) elicited immunity against transplanted syngeneic (C57BL/6)…”
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Intramuscular administration of expression plasmids encoding interferon-γ receptor/IgG1 or IL-4/IgG1 chimeric proteins protects from autoimmunity by Chang, Yigang, Prud'homme, Gérald J.

“…Background Interferon γ (IFNγ) is an inflammatory cytokine that promotes autoimmune insulitis and diabetes in NOD mice, while interleukin‐4 (IL‐4) is…”
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GABAergic system in the endocrine pancreas: a new target for diabetes treatment by Wan, Yun, Wang, Qinghua, Prud'homme, Gerald J

“…Excessive loss of functional pancreatic β-cell mass, mainly due to apoptosis, is a major factor in the development of hyperglycemia in both type 1 and type 2…”
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