Search Results - "Pruchnic, R"

1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence by Carr, L. K., Steele, D., Steele, S., Wagner, D., Pruchnic, R., Jankowski, R., Erickson, J., Huard, J., Chancellor, M. B.

“…We hereby report a 1-year follow-up on eight women in the first North America trial in which stress urinary incontinence (SUI) was treated with muscle-derived…”
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The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence by Lee, J Y, Cannon, T W, Pruchnic, R, Fraser, M O, Huard, J, Chancellor, M B

“…Our goal was to determine whether periurethral injection of allogenic muscle-derived stem cells (MDSC) could increase the leak point pressure (LPP) in a…”
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Cell therapy for treatment of stress urinary incontinence in women: potential dose effect of autologous muscle-derived cells for urinary sphincter repair (AMDC-USR) by Jankowski, R, Werner, S, Snyder, S, Chancellor, M, Kultgen, P, Pruchnic, R

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Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction by HUARD, J, YOKOYAMA, T, PRUCHNIC, R, QU, Z, LI, Y, LEE, J. Y, SOMOGYI, G. T, DE GROAT, W. C, CHANCELLOR, M. B

“…We have tested the feasibility of muscle-based gene therapy and tissue engineering for urological dysfunction using highly purified muscle-derived cells (MDC)…”
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The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells by Musgrave, D.S, Pruchnic, R, Wright, V, Bosch, P, Ghivizzani, S.C, Robbins, P.D, Huard, J

“…The identification of bone morphogenetic proteins (BMPs) has stimulated intense interest in BMP delivery approaches. Ex vivo BMP-2 gene delivery has recently…”
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The role of receptors in the maturation-dependent adenoviral transduction of myofibers by CAO, B, PRUCHNIC, R, IKEZAWA, M, XIAO, X, LI, J, WICKHAM, T. J, KOVESDI, I, RUDERT, W. A, HUARD, J

“…One of the major hurdles facing the application of adenoviral gene transfer to skeletal muscle is the maturation-dependent transduction of muscle myofibers. It…”
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Identification of a Novel Population of Muscle Stem Cells in Mice: Potential for Muscle Regeneration by Qu-Petersen, Zhuqing, Deasy, Bridget, Jankowski, Ron, Ikezawa, Makato, Cummins, James, Pruchnic, Ryan, Mytinger, John, Cao, Baohong, Gates, Charley, Wernig, Anton, Huard, Johnny

“…Three populations of myogenic cells were isolated from normal mouse skeletal muscle based on their adhesion characteristics and proliferation behaviors…”
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A double-blind, randomized, placebo-controlled clinical trial evaluating the safety and efficacy of autologous muscle derived cells in female subjects with stress urinary incontinence by Jankowski, Ron J., Tu, Le Mai, Carlson, Christopher, Robert, Magali, Carlson, Kevin, Quinlan, David, Eisenhardt, Andreas, Chen, Min, Snyder, Scott, Pruchnic, Ryan, Chancellor, Michael, Dmochowski, Roger, Kaufman, Melissa R., Carr, Lesley

“…Purpose The purpose of the study was to assess safety and efficacy of autologous muscle derived cells for urinary sphincter repair (AMDC-USR) in female…”
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Exercise training increases intramyocellular lipid and oxidative capacity in older adults by Pruchnic, Ryan, Katsiaras, Andreas, He, Jing, Kelley, David E, Winters, Carena, Goodpaster, Bret H

“…Intramyocellular lipid (IMCL) has been associated with insulin resistance. However, an association between IMCL and insulin resistance might be modulated by…”
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Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra by Cannon, Tracy W, Lee, Ji Youl, Somogyi, George, Pruchnic, Ryan, Smith, Christopher P, Huard, Johnny, Chancellor, Michael B

“…To study the physiologic outcome of allogenic transplant of muscle-derived progenitor cells (MDPCs) in the denervated female rat urethra. MDPCs were isolated…”
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Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy by Qu, Zhuqing, Balkir, Levent, Judith C. T. van Deutekom, Robbins, Paul D., Pruchnic, Ryan, Huard, Johnny

“…Myoblast transplantation has been extensively studied as a gene complementation approach for genetic diseases such as Duchenne Muscular Dystrophy. This…”
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Biaxial mechanical properties of muscle-derived cell seeded small intestinal submucosa for bladder wall reconstitution by Lu, Shing-Hwa, Sacks, Michael S, Chung, Steve Y, Gloeckner, D.Claire, Pruchnic, Ryan, Huard, Johnny, de Groat, William C, Chancellor, Michael B

“…Bladder wall replacement remains a challenging problem for urological surgery due to leakage, infection, stone formation, and extensive time needed for tissue…”
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Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2 by Musgrave, D. S., Pruchnic, R., Bosch, P., Ziran, B. H., Whalen, J., Huard, J.

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Autologous primary muscle-derived cells transfer into the lower urinary tract by Yokoyama, T, Pruchnic, R, Lee, J Y, Chuang, Y C, Jumon, H, Yoshimura, N, de Groat, W C, Huard, J, Chancellor, M B

“…The goal of these experiments was to establish the basic methodology for future clinical applications of muscle-derived cells (MDC) tissue engineering and gene…”
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Muscle-derived stem cells seeded into acellular scaffolds develop calcium-dependent contractile activity that is modulated by nicotinic receptors by Lu, Shing-Hwa, Cannon, Tracy W, Chermanski, Christopher, Pruchnic, Ryan, Somogyi, George, Sacks, Michael, de Groat, William C, Huard, Johnny, Chancellor, Michael B

“…To explore the contractile activity and physiologic properties of muscle-derived stem cells (MDSCs) incorporated into small intestinal submucosa (SIS)…”
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Muscle-derived cell transplantation and differentiation into lower urinary tract smooth muscle by Yokoyama, Teruhiko, Huard, Johnny, Pruchnic, Ryan, Yoshimura, Naoki, Qu, Zhuqing, Cao, Baohong, de Groat, William C, Kumon, Hiromi, Chancellor, Michael B

“…Objectives. To explore the feasibility of primary skeletal muscle-derived cell (MDC)-based tissue engineering and gene transfer into the lower urinary tract…”
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The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers by Pruchnic, R, Cao, B, Peterson, Z Q, Xiao, X, Li, J, Samulski, R J, Epperly, M, Huard, J

“…Muscle-based gene therapy using adenovirus, retrovirus, and herpes simplex virus has been hindered by viral cytotoxicity, host immune response, and the…”
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Dystrophin delivery in dystrophin-deficient DMDmdx skeletal muscle by isogenic muscle-derived stem cell transplantation by Ikezawa, Makoto, Cao, Baohong, Qu, Zhuqing, Peng, Hairong, Xiao, Xiao, Pruchnic, Ryan, Kimura, Shigemi, Miike, Teruhisa, Huard, Johnny

“…Duchenne's muscular dystrophy (DMD) is a lethal muscle disease caused by a lack of dystrophin expression at the sarcolemma of muscle fibers. We investigated…”
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Gene therapy strategies for urological dysfunction by Chancellor, Michael B, Yoshimura, Naoki, Pruchnic, Ryan, Huard, Johnny

“…Novel molecular techniques such as conventional and ex vivo gene therapy, and tissue engineering have only recently been introduced to the field of urology…”
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State of the art of where we are at using stem cells for stress urinary incontinence by Furuta, A, Jankowski, RJ, Honda, M, Pruchnic, R, Yoshimura, N, Chancellor, MB

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