Search Results - "Prowse, David M."

Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas by Stankiewicz, Elzbieta, Prowse, David M, Ng, Mansum, Cuzick, Jack, Mesher, David, Hiscock, Frances, Lu, Yong-Jie, Watkin, Nicholas, Corbishley, Catherine, Lam, Wayne, Berney, Daniel M

“…The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood, though risk factors include human papillomavirus (HPV). Disruption of…”
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WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics by Bisson, Isabelle, Prowse, David M

“…Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells…”
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Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling by Shaw, Greg, Prowse, David M

“…Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer…”
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Pak1 Phosphorylation on T212 Affects Microtubules in Cells Undergoing Mitosis by Banerjee, Monisha, Worth, Daniel, Prowse, David M, Nikolic, Margareta

“…The Pak kinases are targets of the Rho GTPases Rac and Cdc42, which regulate cell shape and motility [1–5]. It is increasingly apparent that part of this…”
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GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state by Nadendla, Sandeep K, Hazan, Allon, Ward, Matt, Harper, Lisa J, Moutasim, Karwan, Bianchi, Lucia S, Naase, Mahmoud, Ghali, Lucy, Thomas, Gareth J, Prowse, David M, Philpott, Michael P, Neill, Graham W

“…The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they…”
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Distinct epidermal stem cell compartments are maintained by independent niche microenvironments by Braun, Kristin M, Prowse, David M

“…The mammalian epidermis is a stratified, multilayered epithelium, consisting of the interfollicular epidermis and associated appendages, which extend into the…”
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Detection of TMPRSS2：ERG fusion gene in circulating prostate cancer cells by Mao, Xueying, Shaw, Greg, James, Sharon Y., Purkis, Patricia, Kudahetti, Sakunthala C., Tsigani, Theodora, Kia, Saname, Young, Bryan D., Oliver, R. Tim D., Berney, Dan, Prowse, David M., Lu, Yong‐Jie

“…Aim： To investigate the existence of TMPRSS2：ERG fusion gene in circulating tumor cells （CTC） from prostate cancer patients and its potential in monitoring…”
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Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours by Lo Celso, Cristina, Prowse, David M, Watt, Fiona M

“…When beta-catenin signalling is disturbed from mid-gestation onwards lineage commitment is profoundly altered in postnatal mouse epidermis. We have…”
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β-Catenin and Hedgehog Signal Strength Can Specify Number and Location of Hair Follicles in Adult Epidermis without Recruitment of Bulge Stem Cells by Silva-Vargas, Violeta, Lo Celso, Cristina, Giangreco, Adam, Ofstad, Tyler, Prowse, David M., Braun, Kristin M., Watt, Fiona M.

“…Using K14ΔNβ-cateninER transgenic mice, we show that short-term, low-level β-catenin activation stimulates de novo hair follicle formation from sebaceous…”
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Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia by Prowse, David M, Lee, David, Weiner, Lorin, Jiang, Nanyan, Magro, Cynthia M, Baden, Howard P, Brissette, Janice L

“…Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from…”
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HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis by Stankiewicz, Elzbieta, Kudahetti, Sakunthala C, Prowse, David M, Ktori, Elena, Cuzick, Jack, Ambroisine, Laurence, Zhang, Xiaoxi, Watkin, Nicholas, Corbishley, Catherine, Berney, Daniel M

“…Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and…”
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International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate: a meta‐analysis of 1446 patients by Shaw, Greg L., Wilson, Peter, Cuzick, Jack, Prowse, David M., Goldenberg, S. Larry, Spry, Nigel A., Oliver, Tim

“…OBJECTIVE To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of…”
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Hedgehog Signalling in Androgen Independent Prostate Cancer by Shaw, Greg, Price, Anna M, Ktori, Elena, Bisson, Isabelle, Purkis, Patricia E, McFaul, Siobhan, Oliver, R. Tim D, Prowse, David M

“…Abstract Objectives Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis…”
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The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma by Stankiewicz, Elzbieta, Prowse, David M, Ktori, Elena, Cuzick, Jack, Ambroisine, Laurence, Zhang, Xiaoxi, Kudahetti, Sakunthala, Watkin, Nicholas, Corbishley, Catherine, Berney, Daniel M

“…Stankiewicz E, Prowse D M, Ktori E, Cuzick J, Ambroisine L, Zhang X, Kudahetti S, Watkin N, Corbishley C & Berney D M
(2011) Histopathology58, 433–439
The…”
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Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt by Janes, Sam M, Ofstad, Tyler A, Campbell, Douglas H, Watt, Fiona M, Prowse, David M

“…The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype…”
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Exposing the human nude phenotype by Frank, Jorge, Pignata, Claudio, Panteleyev, Andrei A, Prowse, David M, Baden, Howard, Weiner, Lorin, Gaetaniello, Lucia, Ahmad, Wasim, Pozzi, Nicola, Cserhalmi-Friedman, Peter B, Aita, Vincent M, Uyttendaele, Hendrik, Gordon, Derek, Ott, Jurg, Brissette, Janice L, Christiano, Angela M

“…The recent discovery of the human counterpart of the hairless mouse phenotype has helped our understanding of the molecular genetics of hair growth. But there…”
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Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients by Husain, Ehab, Prowse, David M., Ktori, Elena, Shaikh, Taufiq, Yaqoob, Magdi, Junaid, Islam, Baithun, Suhail

“…We investigated the role of human papillomavirus (HPV) in the development of transitional cell carcinoma (TCC) arising in renal transplant recipients. Genomic…”
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Re: Christine McKillop. Interview with Jack Schalken: PCA3 and its Use as a Diagnostic Test in Prostate Cancer. Eur Urol 2006;50:153–154 by Shaw, Greg, Oliver, R. Tim D, Purkiss, Trisha, Prowse, David M

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Developmental signals in skin morphogenesis by Prowse, David M.

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Association between MousenudeGene Expression and the Initiation of Epithelial Terminal Differentiation by Lee, David, Prowse, David M., Brissette, Janice L.

“…Loss-of-function mutations in Whn (Hfh 11), a winged-helix/forkhead transcription factor, result in the nude mouse phenotype. To determine thewhnexpression…”
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