Search Results - "Provis, Jan M"

Retinal microglia: Just bystander or target for therapy? by Karlstetter, Marcus, Scholz, Rebecca, Rutar, Matt, Wong, Wai T., Provis, Jan M., Langmann, Thomas

“…Resident microglial cells can be regarded as the immunological watchdogs of the brain and the retina. They are active sensors of their neuronal…”
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Adaptation of the central retina for high acuity vision: Cones, the fovea and the avascular zone by Provis, Jan M., Dubis, Adam M., Maddess, Ted, Carroll, Joseph

“…Presence of a fovea centralis is directly linked to molecular specification of an avascular area in central retina, before the fovea (or ‘pit’) begins to form…”
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Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration by Rutar, Matt, Natoli, Riccardo, Provis, Jan M

“…The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related…”
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Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration by Racic, Tanja, Chang, Andrew, Fernando, Nilisha, Brandli, Alice, Natoli, Riccardo, Penfold, Philip, Provis, Jan M., Rutar, Matt

“…The pathogenesis of outer retinal degenerations has been linked to the elevation of cytokines that orchestrate pro-inflammatory responses within the retinal…”
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Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration by Jiao, Haihan, Natoli, Riccardo, Valter, Krisztina, Provis, Jan M, Rutar, Matt

“…The recruitment of macrophages accompanies almost every pathogenic state of the retina, and their excessive activation in the subretinal space is thought to…”
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Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina by Rutar, Matt, Valter, Krisztina, Natoli, Riccardo, Provis, Jan M

“…Complement activation is thought to contribute to the pathogenesis of age-related macular degeneration (AMD), which may be mediated in part by…”
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Early focal expression of the chemokine Ccl2 by Müller cells during exposure to damage-inducing bright continuous light by Rutar, Matt, Natoli, Riccardo, Valter, Krisztina, Provis, Jan M

“…To investigate the time course and localization of Ccl2 expression and recruitment of inflammatory cells associated with light-induced photoreceptor…”
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Brief Exposure to Damaging Light Causes Focal Recruitment of Macrophages, and Long-Term Destabilization of Photoreceptors in the Albino Rat Retina by Rutar, Matt, Provis, Jan M., Valter, Krisztina

“…Purpose: To characterize the long-term spatiotemporal features of light-mediated retinal degeneration. Methods: Sprague-Dawley rats were exposed to 1000 lux…”
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Immunological and Aetiological Aspects of Macular Degeneration by Penfold, Philip L, Madigan, Michele C, Gillies, Mark C, Provis, Jan M

“…Aetiological and immunological aspects of AMD, a leading cause of blindness in Western countries, have been reviewed. Developmental studies suggest that…”
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Stem Cell Activity in the Developing Human Cornea by Davies, Sarah B., Chui, Jeanie, Madigan, Michelle C., Provis, Jan M., Wakefield, Denis, Di Girolamo, Nick

“…The adult cornea harbors stem cells (SCs) in its periphery, in a niche known as the limbus. Over the past 2 decades there has been substantial research into…”
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Corrigendum to “Anti-inflammatory and neuroprotective properties of the corticosteroid fludrocortisone in retinal degeneration” [Exp. Eye Res. 212 (2021) 108765] by Racic, Tanja, Chang, Andrew, Fernando, Nilisha, Brandli, Alice, Natoli, Riccardo, Penfold, Philip, Provis, Jan M., Rutar, Matt

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Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration by Rutar, Matt, Natoli, Riccardo, Kozulin, Peter, Valter, Krisztina, Gatenby, Paul, Provis, Jan M

“…To investigate the expression and localization of complement system mRNA and protein in a light-induced model of progressive retinal degeneration…”
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Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage by Jiao, Haihan, Provis, Jan M, Natoli, Riccardo, Rutar, Matt

“…PurposeDysregulation of the complement cascade contributes to a variety of retinal dystrophies, including age-related macular degeneration (AMD). The central…”
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Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium by Rutar, Matt, Natoli, Riccardo, Chia, R X, Valter, Krisztina, Provis, Jan M

“…Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of…”
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Evaluation of normal human foveal development using optical coherence tomography and histologic examination by Dubis, Adam M, Costakos, Deborah M, Subramaniam, C Devika, Godara, Pooja, Wirostko, William J, Carroll, Joseph, Provis, Jan M

“…To assess outer retinal layer maturation during late gestation and early postnatal life using optical coherence tomography and histologic examination…”
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Role of Chemokines in Shaping Macrophage Activity in AMD by Rutar, Matt, Provis, Jan M

“…Age-related macular degeneration (AMD) is a multifactorial disorder that affects millions of individuals worldwide. While the advent of anti-VEGF therapy has…”
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Identification of miRNAs in a Model of Retinal Degenerations by Saxena, Kartik, Rutar, Matthew Viktor, Provis, Jan M, Natoli, Riccardo Carlo

“…We investigated the expression profile of and identify all microRNAs (miRNAs) that potentially regulate inflammation in a light-induced model of focal retinal…”
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A model of progressive photo-oxidative degeneration and inflammation in the pigmented C57BL/6J mouse retina by Natoli, Riccardo, Jiao, Haihan, Barnett, Nigel L., Fernando, Nilisha, Valter, Krisztina, Provis, Jan M., Rutar, Matt

“…Light–induced degeneration in rodent retinas is an established model for of retinal degeneration, including the roles of oxidative stress and neuroinflammatory…”
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Preservation of the Foveal Avascular Zone in Achromatopsia Despite the Absence of a Fully Formed Pit by Linderman, Rachel E, Georgiou, Michalis, Woertz, Erica N, Cava, Jenna A, Litts, Katie M, Tarima, Sergey, Rajendram, Ranjan, Provis, Jan M, Michaelides, Michel, Carroll, Joseph

“…To examine the foveal avascular zone (FAZ) in patients with congenital achromatopsia (ACHM). Forty-two patients with genetically confirmed ACHM were imaged…”
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VEGF expression by ganglion cells in central retina before formation of the foveal depression in monkey retina: Evidence of developmental hypoxia by Sandercoe, Trent M., Geller, Scott F., Hendrickson, Anita E., Stone, Jonathan, Provis, Jan M.

“…In macaque monkeys the foveal depression forms between fetal day (Fd) 105 and birth (Fd 172 of gestation). Before this, the incipient fovea is identified by a…”
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