Search Results - "Provero, Paolo"

Differential Co-Expression Analyses Allow the Identification of Critical Signalling Pathways Altered during Tumour Transformation and Progression by Savino, Aurora, Provero, Paolo, Poli, Valeria

“…Biological systems respond to perturbations through the rewiring of molecular interactions, organised in gene regulatory networks (GRNs). Among these, the…”
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Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs by Tay, Yvonne, Kats, Lev, Salmena, Leonardo, Weiss, Dror, Tan, Shen Mynn, Ala, Ugo, Karreth, Florian, Poliseno, Laura, Provero, Paolo, Di Cunto, Ferdinando, Lieberman, Judy, Rigoutsos, Isidore, Pandolfi, Pier Paolo

“…Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for common microRNAs, with microRNA response elements as the foundation of…”
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PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy by Salaroglio, Iris C, Panada, Elisa, Moiso, Enrico, Buondonno, Ilaria, Provero, Paolo, Rubinstein, Menachem, Kopecka, Joanna, Riganti, Chiara

“…Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response…”
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Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells by Janiszewska, Michalina, Suvà, Mario L, Riggi, Nicolo, Houtkooper, Riekelt H, Auwerx, Johan, Clément-Schatlo, Virginie, Radovanovic, Ivan, Rheinbay, Esther, Provero, Paolo, Stamenkovic, Ivan

“…Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that…”
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Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments by Ala, Ugo, Karreth, Florian A., Bosia, Carla, Pagnani, Andrea, Taulli, Riccardo, Léopold, Valentine, Tay, Yvonne, Provero, Paolo, Zecchina, Riccardo, Pandolfi, Pier Paolo

“…Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of shared microRNAs and form complex regulatory networks based on their…”
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Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation by Procopio, Maria-Giuseppina, Laszlo, Csaba, Al Labban, Dania, Kim, Dong Eun, Bordignon, Pino, Jo, Seung-Hee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo, Provero, Paolo, Hoetzenecker, Wolfram, Neel, Victor, Kilarski, Witold W., Swartz, Melody A., Brisken, Cathrin, Lefort, Karine, Dotto, G. Paolo

“…Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are…”
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In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma by Karreth, Florian A., Tay, Yvonne, Perna, Daniele, Ala, Ugo, Tan, Shen Mynn, Rust, Alistair G., DeNicola, Gina, Webster, Kaitlyn A., Weiss, Dror, Perez-Mancera, Pedro A., Krauthammer, Michael, Halaban, Ruth, Provero, Paolo, Adams, David J., Tuveson, David A., Pandolfi, Pier Paolo

“…We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements…”
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Somatic mutagenesis in satellite cells associates with human skeletal muscle aging by Franco, Irene, Johansson, Anna, Olsson, Karl, Vrtačnik, Peter, Lundin, Pär, Helgadottir, Hafdis T., Larsson, Malin, Revêchon, Gwladys, Bosia, Carla, Pagnani, Andrea, Provero, Paolo, Gustafsson, Thomas, Fischer, Helene, Eriksson, Maria

“…Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident…”
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EZH2 is essential for glioblastoma cancer stem cell maintenance by Suvà, Mario-Luca, Riggi, Nicolò, Janiszewska, Michalina, Radovanovic, Ivan, Provero, Paolo, Stehle, Jean-Christophe, Baumer, Karine, Le Bitoux, Marie-Aude, Marino, Denis, Cironi, Luisa, Marquez, Victor E, Clément, Virginie, Stamenkovic, Ivan

“…Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and…”
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The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis by Fusella, Federica, Seclì, Laura, Busso, Elena, Krepelova, Anna, Moiso, Enrico, Rocca, Stefania, Conti, Laura, Annaratone, Laura, Rubinetto, Cristina, Mello-Grand, Maurizia, Singh, Vijay, Chiorino, Giovanna, Silengo, Lorenzo, Altruda, Fiorella, Turco, Emilia, Morotti, Alessandro, Oliviero, Salvatore, Castellano, Isabella, Cavallo, Federica, Provero, Paolo, Tarone, Guido, Brancaccio, Mara

“…NF-κB is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell…”
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Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer by Planche, Anne, Bacac, Marina, Provero, Paolo, Fusco, Carlo, Delorenzi, Mauro, Stehle, Jean-Christophe, Stamenkovic, Ivan

“…Primary tumor growth induces host tissue responses that are believed to support and promote tumor progression. Identification of the molecular characteristics…”
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Subtype-Specific Metagene-Based Prediction of Outcome after Neoadjuvant and Adjuvant Treatment in Breast Cancer by Callari, Maurizio, Cappelletti, Vera, D'Aiuto, Francesca, Musella, Valeria, Lembo, Antonio, Petel, Fabien, Karn, Thomas, Iwamoto, Takayuki, Provero, Paolo, Daidone, Maria Grazia, Gianni, Luca, Bianchini, Giampaolo

“…In spite of improvements of average benefit from adjuvant/neoadjuvant treatments, there are still individual patients with early breast cancer at high risk of…”
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The frequency of somatic mutations in cancer predicts the phenotypic relevance of germline mutations by Draetta, Edoardo Luigi, Lazarević, Dejan, Provero, Paolo, Cittaro, Davide

“…Genomic sequence mutations can be pathogenic in both germline and somatic cells. Several authors have observed that often the same genes are involved in cancer…”
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An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates by Gays, Dafne, Hess, Christopher, Camporeale, Annalisa, Ala, Ugo, Provero, Paolo, Mosimann, Christian, Santoro, Massimo M

“…Intestinal smooth muscle cells (iSMCs) are a crucial component of the adult gastrointestinal tract and support intestinal differentiation, peristalsis and…”
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Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells by Tapparo, Marta, Bruno, Stefania, Collino, Federica, Togliatto, Gabriele, Deregibus, Maria Chiara, Provero, Paolo, Wen, Sicheng, Quesenberry, Peter J, Camussi, Giovanni

“…Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) possess pro-regenerative potential in different animal models with renal injury. EVs…”
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miR148b is a major coordinator of breast cancer progression in a relapse‐associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1 by Cimino, Daniela, De Pittà, Cristiano, Orso, Francesca, Zampini, Matteo, Casara, Silvia, Penna, Elisa, Quaglino, Elena, Forni, Marco, Damasco, Christian, Pinatel, Eva, Ponzone, Riccardo, Romualdi, Chiara, Brisken, Cathrin, De Bortoli, Michele, Biglia, Nicoletta, Provero, Paolo, Lanfranchi, Gerolamo, Taverna, Daniela

“…Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77…”
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EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells by Riggi, Nicolò, Suvà, Mario-Luca, De Vito, Claudio, Provero, Paolo, Stehle, Jean-Christophe, Baumer, Karine, Cironi, Luisa, Janiszewska, Michalina, Petricevic, Tanja, Suvà, Domizio, Tercier, Stéphane, Joseph, Jean-Marc, Guillou, Louis, Stamenkovic, Ivan

“…Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of normal tissue stem cells, but the events responsible for their emergence…”
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Total Binding Affinity Profiles of Regulatory Regions Predict Transcription Factor Binding and Gene Expression in Human Cells by Grassi, Elena, Zapparoli, Ettore, Molineris, Ivan, Provero, Paolo

“…Transcription factors regulate gene expression by binding regulatory DNA. Understanding the rules governing such binding is an essential step in describing the…”
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The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation by Fiorito, Veronica, Allocco, Anna Lucia, Petrillo, Sara, Gazzano, Elena, Torretta, Simone, Marchi, Saverio, Destefanis, Francesca, Pacelli, Consiglia, Audrito, Valentina, Provero, Paolo, Medico, Enzo, Chiabrando, Deborah, Porporato, Paolo Ettore, Cancelliere, Carlotta, Bardelli, Alberto, Trusolino, Livio, Capitanio, Nazzareno, Deaglio, Silvia, Altruda, Fiorella, Pinton, Paolo, Cardaci, Simone, Riganti, Chiara, Tolosano, Emanuela

“…Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High rates of heme synthesis are commonly observed in proliferating…”
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Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension by Naldi, Andrea, Provero, Paolo, Vercelli, Alessandro, Bergui, Mauro, Mazzeo, Anna Teresa, Cantello, Roberto, Tondo, Giacomo, Lochner, Piergiorgio

“…Background Ultrasonography of the optic nerve sheath diameter (ONSD) is used for the non-invasive assessment of increased intracranial pressure (ICP). ONSD…”
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