Search Results - "Provasi, Elena"

Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method by Andriolo, Gabriella, Provasi, Elena, Lo Cicero, Viviana, Brambilla, Andrea, Soncin, Sabrina, Torre, Tiziano, Milano, Giuseppina, Biemmi, Vanessa, Vassalli, Giuseppe, Turchetto, Lucia, Barile, Lucio, Radrizzani, Marina

“…Exosomes, nanosized membrane vesicles secreted by cardiac progenitor cells (Exo-CPC), inhibit cardiomyocyte apoptosis under stress conditions, promote…”
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Site-specific integration and tailoring of cassette design for sustainable gene transfer by Lombardo, Angelo, Cesana, Daniela, Genovese, Pietro, Di Stefano, Bruno, Provasi, Elena, Colombo, Daniele F, Neri, Margherita, Magnani, Zulma, Cantore, Alessio, Lo Riso, Pietro, Damo, Martina, Pello, Oscar M, Holmes, Michael C, Gregory, Philip D, Gritti, Angela, Broccoli, Vania, Bonini, Chiara, Naldini, Luigi

“…Presented is an experimental analysis of the stability of transgene expression, the perturbation of endogenous expression and the perturbation of epigenetic…”
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Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells by De Luca, Michele, Mavilio, Fulvio, Pellegrini, Graziella, Ferrari, Stefano, Di Nunzio, Francesca, Di Iorio, Enzo, Recchia, Alessandra, Maruggi, Giulietta, Ferrari, Giuliana, Provasi, Elena, Bonini, Chiara, Capurro, Sergio, Conti, Andrea, Magnoni, Cristina, Giannetti, Alberto

“…The continuous renewal of human epidermis is sustained by stem cells contained in the epidermal basal layer and in hair follicles. Cultured keratinocyte stem…”
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Sirolimus Therapy for Patients With Lymphangioleiomyomatosis Leads to Loss of Chylous Ascites and Circulating LAM Cells by Harari, Sergio, MD, Elia, Davide, MD, Torre, Olga, MD, Bulgheroni, Elisabetta, MSc, Provasi, Elena, PhD, Moss, Joel, MD, PhD, FCCP

“…A young woman received a diagnosis of abdominal, sporadic lymphangioleiomyomatosis (LAM) and multiple abdominal lymphangioleiomyomas and was referred for…”
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IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors by Cieri, Nicoletta, Camisa, Barbara, Cocchiarella, Fabienne, Forcato, Mattia, Oliveira, Giacomo, Provasi, Elena, Bondanza, Attilio, Bordignon, Claudio, Peccatori, Jacopo, Ciceri, Fabio, Lupo-Stanghellini, Maria Teresa, Mavilio, Fulvio, Mondino, Anna, Bicciato, Silvio, Recchia, Alessandra, Bonini, Chiara

“…Long-living memory stem T cells (TSCM) with the ability to self-renew and the plasticity to differentiate into potent effectors could be valuable weapons in…”
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Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells by De Simone, Marco, Arrigoni, Alberto, Rossetti, Grazisa, Gruarin, Paola, Ranzani, Valeria, Politano, Claudia, Bonnal, Raoul J.P., Provasi, Elena, Sarnicola, Maria Lucia, Panzeri, Ilaria, Moro, Monica, Crosti, Mariacristina, Mazzara, Saveria, Vaira, Valentina, Bosari, Silvano, Palleschi, Alessandro, Santambrogio, Luigi, Bovo, Giorgio, Zucchini, Nicola, Totis, Mauro, Gianotti, Luca, Cesana, Giancarlo, Perego, Roberto A., Maroni, Nirvana, Pisani Ceretti, Andrea, Opocher, Enrico, De Francesco, Raffaele, Geginat, Jens, Stunnenberg, Hendrik G., Abrignani, Sergio, Pagani, Massimiliano

“…Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for tumor antigens. Deeper molecular definitions of…”
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The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4 by Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul J P, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimiliano

“…Long intergenic noncoding RNAs (lincRNAs) contribute to the regulation of gene expression. Pagani and colleagues identify hundreds of unique lincRNAs expressed…”
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Extracellular vesicles selective capture by peptide-functionalized hollow fiber membranes by Salerno, Simona, Piscioneri, Antonella, Morelli, Sabrina, Gori, Alessandro, Provasi, Elena, Gagni, Paola, Barile, Lucio, Cretich, Marina, Chiari, Marcella, De Bartolo, Loredana

“…[Display omitted] •HF membranes are modified by a nanometric coating with a copoly azide polymer to limit non-specific interactions and to enable the…”
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Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer by Provasi, Elena, Genovese, Pietro, Lombardo, Angelo, Magnani, Zulma, Liu, Pei-Qi, Reik, Andreas, Chu, Victoria, Paschon, David E, Zhang, Lei, Kuball, Jurgen, Camisa, Barbara, Bondanza, Attilio, Casorati, Giulia, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Greenberg, Philip D, Holmes, Michael C, Gregory, Philip D, Naldini, Luigi, Bonini, Chiara

“…Engineered T cells expressing a tumor antigen specific T cell receptor (TCR) have shown promise for cancer immunotherapy. However, the introduced TCR chains…”
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An extracellular vesicle epitope profile is associated with acute myocardial infarction by Burrello, Jacopo, Bolis, Sara, Balbi, Carolina, Burrello, Alessio, Provasi, Elena, Caporali, Elena, Gauthier, Lorenzo Grazioli, Peirone, Andrea, D'Ascenzo, Fabrizio, Monticone, Silvia, Barile, Lucio, Vassalli, Giuseppe

“…The current standard biomarker for myocardial infarction (MI) is high‐sensitive troponin. Although powerful in clinical setting, search for new markers is…”
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Methodologies for Scalable Production of High-Quality Purified Small Extracellular Vesicles from Conditioned Medium by Andriolo, Gabriella, Provasi, Elena, Brambilla, Andrea, Panella, Stefano, Soncin, Sabrina, Cicero, Viviana Lo, Radrizzani, Marina, Turchetto, Lucia, Barile, Lucio

“…The development of an extracellular vesicles (EV)-based therapeutic product requires the implementation of reproducible and scalable, purification protocols…”
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NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease by Mastaglio, Sara, Genovese, Pietro, Magnani, Zulma, Ruggiero, Eliana, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Rocchi, Martina, Oliveira, Giacomo, Escobar, Giulia, Casucci, Monica, Gentner, Bernhard, Spinelli, Antonello, Mondino, Anna, Bondanza, Attilio, Vago, Luca, Ponzoni, Maurilio, Ciceri, Fabio, Holmes, Michael C., Naldini, Luigi, Bonini, Chiara

“…Transfer of T-cell receptors (TCRs) specific for tumor-associated antigens is a promising approach for cancer immunotherapy. We developed the TCR gene editing…”
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Intracoronary delivery of extracellular vesicles from human cardiac progenitor cells reduces infarct size in porcine acute myocardial infarction by Emmert, Maximilian Y, Burrello, Jacopo, Wolint, Petra, Hilbe, Monika, Andriolo, Gabriella, Balbi, Carolina, Provasi, Elena, Turchetto, Lucia, Radrizzani, Marina, Nazari-Shafti, Timo Z, Cesarovic, Nikola, Neuber, Sebastian, Falk, Volkmar, Hoerstrup, Simon P, Hemetsberger, Rayyan, Gyöngyösi, Mariann, Barile, Lucio, Vassalli, Giuseppe

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IL-7 and IL-15 allow the generation of suicide gene–modified alloreactive self-renewing central memory human T lymphocytes by Kaneko, Shin, Mastaglio, Sara, Bondanza, Attilio, Ponzoni, Maurilio, Sanvito, Francesca, Aldrighetti, Luca, Radrizzani, Marina, La Seta-Catamancio, Simona, Provasi, Elena, Mondino, Anna, Nagasawa, Toshiro, Fleischhauer, Katharina, Russo, Vincenzo, Traversari, Catia, Ciceri, Fabio, Bordignon, Claudio, Bonini, Chiara

“…Long-term clinical remissions of leukemia, after allogeneic hematopoietic stem cell transplantation, depend on alloreactive memory T cells able to self-renew…”
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Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation by Lupo-Stanghellini, Maria Teresa, Provasi, Elena, Bondanza, Attilio, Ciceri, Fabio, Bordignon, Claudio, Bonini, Chiara

“…Allogeneic hematopoietic stem cell transplantation (allo-SCT) from an HLA-matched related or unrelated donor is a curative option for patients with high-risk…”
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Lentivirus-induced dendritic cells for immunization against high-risk WT1(+) acute myeloid leukemia by Sundarasetty, Bala Sai, Singh, Vijay Kumar, Salguero, Gustavo, Geffers, Robert, Rickmann, Mareike, Macke, Laura, Borchers, Sylvia, Figueiredo, Constanca, Schambach, Axel, Gullberg, Urban, Provasi, Elena, Bonini, Chiara, Ganser, Arnold, Woelfel, Thomas, Stripecke, Renata

“…Wilms' tumor 1 antigen (WT1) is overexpressed in acute myeloid leukemia (AML), a high-risk neoplasm warranting development of novel immunotherapeutic…”
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LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4 by Ranzani, Valeria, Rossetti, Grazisa, Panzeri, Ilaria, Arrigoni, Alberto, Bonnal, Raoul JP, Curti, Serena, Gruarin, Paola, Provasi, Elena, Sugliano, Elisa, Marconi, Maurizio, De Francesco, Raffaele, Geginat, Jens, Bodega, Beatrice, Abrignani, Sergio, Pagani, Massimiliano

“…Long non-coding-RNAs are emerging as important regulators of cellular functions but little is known on their role in human immune system. Here we investigated…”
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NY-ESO-1 Single Edited T Cells to Treat Multiple Myeloma without Inducing GvHD by Mastaglio, Sara, Genovese, Pietro, Magnani, Zulma, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D, Naldini, Luigi, Bonini, Chiara

“…Background. Gene transfer of T cell receptors (TCR) specific for tumor associated antigens is a promising approach of adoptive immunotherapy for cancer…”
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TCR Gene Editing Achieved In a Single Round Of T Cell Activation Is Sufficient To Redirect T Cell Specificity and Prevent GvHD by Mastaglio, Sara, Genovese, Pietro, Magnani, Zulma, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D, Naldini, Luigi, Bonini, Chiara

“…The genetic transfer of tumor-specific T cell receptors (TCRs) into mature T lymphocytes enables T cell specificity to be redirected towards cancer cells,…”
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209. TCR Gene Editing in a Single Step of T Cell Activation To Redirect T Cell Specificity and Prevent GvHD by Genovese, Pietro, Mastaglio, Sara, Magnani, Zulma, Landoni, Elisa, Camisa, Barbara, Schiroli, Giulia, Provasi, Elena, Lombardo, Angelo, Reik, Andreas, Cieri, Nicoletta, Ponzoni, Maurilio, Ciceri, Fabio, Bordignon, Claudio, Holmes, Michael C., Gregory, Philip D., Naldini, Luigi, Bonini, Chiara

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