Search Results - "Proudfoot, J."

Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut by Proudfoot, Nick J.

“…Terminating transcription is a highly intricate process for mammalian protein-coding genes. First, the chromatin template slows down transcription at the gene…”
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A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression by Skourti-Stathaki, Konstantina, Proudfoot, Nicholas J

“…R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized with the DNA template, leaving the nontemplate DNA single-stranded. R…”
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Transcriptional Control by Premature Termination: A Forgotten Mechanism by Kamieniarz-Gdula, Kinga, Proudfoot, Nick J.

“…The concept of early termination as an important means of transcriptional control has long been established. Even so, its role in metazoan gene expression is…”
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Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination by Skourti-Stathaki, Konstantina, Proudfoot, Nicholas J., Gromak, Natalia

“…We present a molecular dissection of pause site-dependent transcriptional termination for mammalian RNA polymerase II (Pol II)-transcribed genes. We show that…”
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Mammalian NET-Seq reveals genome-wide nascent transcription coupled to RNA processing by Nojima, Takayuki, Gomes, Tomás, Grosso, Ana Rita, Kimura, Hiroshi, Dye, Michael J., Dhir, Somdutta, Carmo-Fonseca, Maria, Proudfoot, Nicholas J.

“…© Copyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license…”
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R-Loops Promote Antisense Transcription across the Mammalian Genome by Tan-Wong, Sue Mei, Dhir, Somdutta, Proudfoot, Nick J.

“…Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination…”
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Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation by Moore, Melissa J., Proudfoot, Nick J.

“…The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly…”
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Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs by Schlackow, Margarita, Nojima, Takayuki, Gomes, Tomas, Dhir, Ashish, Carmo-Fonseca, Maria, Proudfoot, Nick J.

“…Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian genome by RNA polymerase II (Pol II) transcription. Although multiple…”
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POINT technology illuminates the processing of polymerase-associated intact nascent transcripts by Sousa-Luís, Rui, Dujardin, Gwendal, Zukher, Inna, Kimura, Hiroshi, Weldon, Carika, Carmo-Fonseca, Maria, Proudfoot, Nick J., Nojima, Takayuki

“…Mammalian chromatin is the site of both RNA polymerase II (Pol II) transcription and coupled RNA processing. However, molecular details of such…”
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BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair by Hatchi, Elodie, Skourti-Stathaki, Konstantina, Ventz, Steffen, Pinello, Luca, Yen, Angela, Kamieniarz-Gdula, Kinga, Dimitrov, Stoil, Pathania, Shailja, McKinney, Kristine M., Eaton, Matthew L., Kellis, Manolis, Hill, Sarah J., Parmigiani, Giovanni, Proudfoot, Nicholas J., Livingston, David M.

“…The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal…”
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Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence by Nojima, Takayuki, Tellier, Michael, Foxwell, Jonathan, Ribeiro de Almeida, Claudia, Tan-Wong, Sue Mei, Dhir, Somdutta, Dujardin, Gwendal, Dhir, Ashish, Murphy, Shona, Proudfoot, Nick J.

“…Extensive tracts of the mammalian genome that lack protein-coding function are still transcribed into long noncoding RNA. While these lncRNAs are generally…”
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Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs by Dhir, Ashish, Dhir, Somdutta, Proudfoot, Nick J, Jopling, Catherine L

“…The finding that miRNA transcripts originating from long-noncoding-RNA loci use Microprocessor, rather than canonical cleavage and polyadenylation, to…”
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SCAF4 and SCAF8, mRNA Anti-Terminator Proteins by Gregersen, Lea H., Mitter, Richard, Ugalde, Alejandro P., Nojima, Takayuki, Proudfoot, Nicholas J., Agami, Reuven, Stewart, Aengus, Svejstrup, Jesper Q.

“…Accurate regulation of mRNA termination is required for correct gene expression. Here, we describe a role for SCAF4 and SCAF8 as anti-terminators, suppressing…”
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Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination by Kamieniarz-Gdula, Kinga, Gdula, Michal R., Panser, Karin, Nojima, Takayuki, Monks, Joan, Wiśniewski, Jacek R., Riepsaame, Joey, Brockdorff, Neil, Pauli, Andrea, Proudfoot, Nick J.

“…The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and…”
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Pcf11 orchestrates transcription termination pathways in yeast by Grzechnik, Pawel, Gdula, Michal Ryszard, Proudfoot, Nick J

“…In Saccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3,…”
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Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle by Griesbach, Esther, Schlackow, Margarita, Marzluff, William F., Proudfoot, Nick J.

“…Phosphorylated H2A.X is a critical chromatin marker of DNA damage repair (DDR) in higher eukaryotes. However, H2A.X gene expression remains relatively…”
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Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability by Mischo, Hannah E., Gómez-González, Belén, Grzechnik, Pawel, Rondón, Ana G., Wei, Wu, Steinmetz, Lars, Aguilera, Andrés, Proudfoot, Nick J.

“…Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA…”
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Cohesin Complex Promotes Transcriptional Termination between Convergent Genes in S. pombe by Gullerova, Monika, Proudfoot, Nick J.

“…Transcription analyses reported in these studies reveal that convergent genes in S. pombe generate overlapping transcripts in the G1 phase of the cell cycle…”
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Primary microRNA transcripts are processed co-transcriptionally by Gromak, Natalia, Morlando, Mariangela, Ballarino, Monica, Bozzoni, Irene, Pagano, Francesca, Proudfoot, Nick J

“…MicroRNAs are processed by Drosha, and previous data had suggested that this occurred soon after transcription. Following Drosha recruitment and using nuclear…”
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Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells by Gullerova, Monika, Proudfoot, Nick J

“…Previous studies have shown the potential for convergent transcription as a way to induce gene silencing. This Technical Report now demonstrates that…”
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