Search Results - "Proudfoot, Amanda E."

Overcoming hurdles in developing successful drugs targeting chemokine receptors by Schall, Thomas J, Proudfoot, Amanda E. I

“…Key Points Chemokine receptors are attractive therapeutic targets for inflammatory and autoimmune diseases. It is likely that chemokine receptors could be…”
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Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans by Graham, Gerard J., Handel, Tracy M., Proudfoot, Amanda E.I.

“…Recruitment of immune cells from the vasculature relies on the presentation of glycosaminoglycan-bound chemokines on the luminal side of vascular endothelial…”
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Chemokine receptors: multifaceted therapeutic targets by Proudfoot, Amanda E. I

“…Chemokines and their receptors are involved in the pathogenesis of diseases ranging from asthma to AIDS. Chemokine receptors are G-protein-coupled serpentine…”
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Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System by Proudfoot, Amanda E I, Johnson, Zoë, Bonvin, Pauline, Handel, Tracy M

“…Chemokines have two types of interactions that function cooperatively to control cell migration. Chemokine receptors on migrating cells integrate signals…”
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A knottin scaffold directs the CXC-chemokine–binding specificity of tick evasins by Lee, Angela W., Deruaz, Maud, Lynch, Christopher, Davies, Graham, Singh, Kamayani, Alenazi, Yara, Eaton, James R.O., Kawamura, Akane, Shaw, Jeffrey, Proudfoot, Amanda E.I., Dias, João M., Bhattacharya, Shoumo

“…Tick evasins (EVAs) bind either CC- or CXC-chemokines by a poorly understood promiscuous or “one-to-many” mechanism to neutralize inflammation. Because EVAs…”
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Evasins: Tick Salivary Proteins that Inhibit Mammalian Chemokines by Bhusal, Ram Prasad, Eaton, James R.O., Chowdhury, Sayeeda T., Power, Christine A., Proudfoot, Amanda E.I., Stone, Martin J., Bhattacharya, Shoumo

“…Ticks are hematophagous arachnids that parasitize mammals and other hosts, feeding on their blood. Ticks secrete numerous salivary factors that enhance host…”
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Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium by von Hundelshausen, Philipp, Koenen, Rory R., Sack, Markus, Mause, Sebastian F., Adriaens, Wencke, Proudfoot, Amanda E.I., Hackeng, Tilman M., Weber, Christian

“…The chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and…”
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The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice by de Albuquerque Taddei, Silvana R, Queiroz-Junior, Celso M, Moura, Adriana P, Andrade, Ildeu, Garlet, Gustavo P, Proudfoot, Amanda E.I, Teixeira, Mauro M, da Silva, Tarcília A

“…Abstract Bone remodeling is affected by mechanical loading and inflammatory mediators, including chemokines. The chemokine (C–C motif) ligand 3 (CCL3) is…”
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CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding by Krohn, Sonja C, Bonvin, Pauline, Proudfoot, Amanda E I

“…CCL18 has been reported to be present constitutively at high levels in the circulation, and is further elevated during inflammatory diseases. Since it is a…”
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Inhibition of Monocyte Chemoattractant Protein-1 Ameliorates Rat Adjuvant-Induced Arthritis by Shahrara, Shiva, Proudfoot, Amanda E. I, Park, Christy C, Volin, Michael V, Haines, G. Kenneth, Woods, James M, Aikens, Christopher H, Handel, Tracy M, Pope, Richard M

“…Chemokines, including RANTES/CCL5 and MCP-1/CCL2, are highly expressed in the joints of patients with rheumatoid arthritis, and they promote leukocyte…”
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Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration by González-Motos, Víctor, Jürgens, Carina, Ritter, Birgit, Kropp, Kai A, Durán, Verónica, Larsen, Olav, Binz, Anne, Ouwendijk, Werner J D, Lenac Rovis, Tihana, Jonjic, Stipan, Verjans, Georges M G M, Sodeik, Beate, Krey, Thomas, Bauerfeind, Rudolf, Schulz, Thomas F, Kaufer, Benedikt B, Kalinke, Ulrich, Proudfoot, Amanda E I, Rosenkilde, Mette M, Viejo-Borbolla, Abel

“…Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection…”
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RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium by VON HUNDELSHAUSEN, Philipp, WEBER, Kim S. C, YUQING HUO, PROUDFOOT, Amanda E. I, NELSON, Peter J, LEY, Klaus, WEBER, Christian

“…Circulating platelets and chemoattractant proteins, such as the CC chemokine RANTES, contribute to the activation and interaction of monocytes and endothelium…”
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Anti-chemokine small molecule drugs: a promising future? by Proudfoot, Amanda E I, Power, Christine A, Schwarz, Matthias K

“…Chemokines have principally been associated with inflammation due to their role in the control of leukocyte migration, but just over a decade ago chemokine…”
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Single Administration of the CXC Chemokine-Binding Protein Evasin-3 During Ischemia Prevents Myocardial Reperfusion Injury in Mice by Montecucco, Fabrizio, Lenglet, Sébastien, Braunersreuther, Vincent, Pelli, Graziano, Pellieux, Corinne, Montessuit, Christophe, Lerch, René, Deruaz, Maud, Proudfoot, Amanda E, Mach, François

“…OBJECTIVE—Evasins (chemokine-binding proteins) have been shown to selectively neutralize chemokine bioactivity. We investigated the potential benefits of…”
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Structural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3 by Dias, João M, Losberger, Christophe, Déruaz, Maud, Power, Christine A, Proudfoot, Amanda E.I, Shaw, Jeffrey P

“…Background: Chemokines are a subset of cytokines responsible for controlling the cellular migration of inflammatory cells through interaction with seven…”
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Kinetics of Chemokine-Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs by Tanino, Yoshi, Coombe, Deirdre R, Gill, Sean E, Kett, Warren C, Kajikawa, Osamu, Proudfoot, Amanda E. I, Wells, Timothy N. C, Parks, William C, Wight, Thomas N, Martin, Thomas R, Frevert, Charles W

“…Chemokine-glycosaminoglycan (GAG) interactions are thought to result in the formation of tissue-bound chemokine gradients. We hypothesized that the binding of…”
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Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice by Charmoy, Mélanie, Brunner-Agten, Saskia, Aebischer, David, Auderset, Floriane, Launois, Pascal, Milon, Geneviève, Proudfoot, Amanda E I, Tacchini-Cottier, Fabienne

“…Neutrophils are rapidly and massively recruited to sites of microbial infection, where they can influence the recruitment of dendritic cells. Here, we have…”
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Molecular Cloning and Characterization of a Highly Selective Chemokine-binding Protein from the Tick Rhipicephalus sanguineus by Frauenschuh, Achim, Power, Christine A., Déruaz, Maud, Ferreira, Beatriz R., Silva, João S., Teixeira, Mauro M., Dias, João M., Martin, Thierry, Wells, Timothy N.C., Proudfoot, Amanda E.I.

“…Ticks are blood-feeding parasites that secrete a number of immuno-modulatory factors to evade the host immune response. Saliva isolated from different species…”
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Chemokines as targets for therapy by Garin, Alexandre, Proudfoot, Amanda E.I.

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Current status of chemokine receptor inhibitors in development by Allegretti, Marcello, Cesta, Maria Candida, Garin, Alexandre, Proudfoot, Amanda E.I

“…Highlights ► Innovative drugs targeting CXC and CC receptors. ► Preclinical and clinical development of drugs acting on chemokine system. ► Perspectives on the…”
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