Search Results - "Protopopova, Anna D"
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Atomic Structural Models of Fibrin Oligomers
Published in Structure (London) (05-06-2018)“…The space-filling fibrin network is a major part of clots and thrombi formed in blood. Fibrin polymerization starts when fibrinogen, a plasma protein, is…”
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Structural insights into TRPV2 activation by small molecules
Published in Nature communications (28-04-2022)“…© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Polymorphism of G4 associates: from stacks to wires via interlocks
Published in Nucleic acids research (28-09-2018)“…Abstract We examined the assembly of DNA G-quadruplexes (G4s) into higher-order structures using atomic force microscopy, optical and electrophoretic methods,…”
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Structural Basis of Interfacial Flexibility in Fibrin Oligomers
Published in Structure (London) (01-11-2016)“…Fibrin is a filamentous network made in blood to stem bleeding; it forms when fibrinogen is converted into fibrin monomers that self-associate into oligomers…”
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Modulation of TRPV2 by endogenous and exogenous ligands: A computational study
Published in Protein science (01-01-2023)“…Transient receptor potential vanilloid (TRPV) channels play various important roles in human physiology. As membrane proteins, these channels are modulated by…”
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Molecular details of ruthenium red pore block in TRPV channels
Published in EMBO reports (13-02-2024)“…Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer…”
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An Improved Substrate for Superior Imaging of Individual Biomacromolecules with Atomic Force Microscopy
Published in Colloids and surfaces, B, Biointerfaces (01-12-2020)“…[Display omitted] •Universal substrate for high-resolution atomic force microscopy of biomacromolecules.•Based on coated highly oriented pyrolytic…”
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Factor XIII topology: organization of B subunits and changes with activation studied with single‐molecule atomic force microscopy
Published in Journal of thrombosis and haemostasis (01-05-2019)“…Essentials Factor XIII is a heterotetramer with 2 catalytic A subunits and 2 non‐catalytic B subunits. Structure of active and inactive factor XIII was studied…”
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Thermal denaturation of fibrinogen visualized by single-molecule atomic force microscopy
Published in Colloids and surfaces, B, Biointerfaces (01-07-2018)“…[Display omitted] •Single unfolded fibrinogen molecules are visualized and characterized using AFM.•Heat denatured fibrinogen is composed of globular and…”
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Morphometric characterization of fibrinogen's αC regions and their role in fibrin self-assembly and molecular organization
Published in Nanoscale (21-09-2017)“…The flexible C-terminal parts of fibrinogen's Aα chains named the αC regions have been shown to play a role in fibrin self-assembly, although many aspects of…”
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A coarse-grained model for DNA origami
Published in Nucleic acids research (16-02-2018)“…Abstract Modeling tools provide a valuable support for DNA origami design. However, current solutions have limited application for conformational analysis of…”
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Kinetic characterization of inhibition of human thrombin with DNA aptamers by turbidimetric assay
Published in Analytical biochemistry (01-02-2012)“…A sensitive turbidimetric method for detecting fibrin association was used to study the kinetics of fibrinogen hydrolysis with thrombin. The data were…”
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62 Visualization of αC regions in fibrin network formation by high-resolution AFM
Published in Journal of biomolecular structure & dynamics (18-05-2015)Get full text
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Investigation of Early Stages of Fibrin Association
Published in Langmuir (19-04-2011)“…Interactions between fibrinogen molecules proteolytically cleaved with thrombin were investigated using atomic force microscopy (AFM) and dynamic light…”
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The role of the 5′-cap structure in viral ribonucleoproteins assembly from potato virus X coat protein and RNAs
Published in Biochimie (01-12-2013)“…The potato virus X (PVX) virion can be reconstituted in vitro from the virus coat protein (CP) and RNA; heterologous RNAs may be used as well. In our recent…”
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TRPV2 modulation by endogenous lipid and exogenous ligand (CBD)
Published in Biophysical journal (11-02-2022)Get full text
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Structural Insights on TRPV2 Gating by Exogenous Modulators
Published in Biophysical journal (07-02-2020)Get full text
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Use of Modified Graphite for Single-Molecule Atomic Force Microscopy of Biomacromolecules
Published in Biophysical journal (15-02-2019)Get full text
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Spatial Structure of Plasma Coagulation Factor XIII and Changes with Activation
Published in Blood (29-11-2018)“…Introduction Blood coagulation factor XIII (FXIII) is a precursor of the active transglutaminase (FXIIIa) that catalyzes covalent cross-linking within…”
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TRPV2 Modulation by Small Molecules and Lipids
Published in Biophysical journal (12-02-2021)Get full text
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