Search Results - "Proto, Justin T."

Intramolecular Didehydro-Diels–Alder Reaction for the Synthesis of Benzo- and Dihydrobenzo-Fused Heterocycles by Bober, Ashley E, Proto, Justin T, Brummond, Kay M

“…Using an intramolecular didehydro-Diels–Alder reaction, ene–yne substituted pyrroles, thiophenes, and furans afford functionalized indoles, benzothiophenes,…”
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Abstract B129: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers by Smith, Bryan D, Vogeti, Lakshminarayana, Gupta, Anu, Singh, Jarnail, Al-Ani, Gada, Bulfer, Stacie L, Caldwell, Timothy M, Timson, Mary J, Vogeti, Subha, Ahn, Yu Mi, Al-Hashimi, Hikmat, Crawley, Chase K, Heiniger, Cale L, Leary, Cynthia B, Proto, Justin T, Shen, Quanrong, Telikepalli, Hanumaiah, Yates, Karen, Lu, Wei-Ping, Flynn, Daniel L

“…Abstract Background: Cancer cells activate autophagy, a catabolic process to resupply nutrients and recycle damaged organelles, in order to survive stresses…”
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Abstract 4045: DCC-3084, a RAF dimer inhibitor, broadly inhibits BRAF class I, II, III, BRAF fusions, and RAS-driven solid tumors leading to tumor regression in preclinical models by Bulfer, Stacie L., Bourdonnec, Bertrand Le, Zwicker, Jeffery D., Ahn, Yu Mi, Al-Ani, Gada, Al-Hashimi, Hikmat, Crawley, Chase, Elliott, Kristin M., Faisal, Saqib, Harned, Andrew M., Heiniger, Cale L., Hood, Molly M., Javed, Salim, Kennedy, Michael, Large, Joshua W., Leary, Cynthia B., Lu, Wei-Ping, Luther, Kylie, Petty, Max D., Picard, Hunter R., Proto, Justin T., Romero, Yeni K., Stanley, Forrest A., Stoltz, Kristen L., Tanner, Daniel C., Telikepalli, Hanumaiah, Timson, Mary J., Vogeti, Lakshminarayana, Vogeti, Subha, Yang, Sihyung, Zhong, Lexy H., Smith, Bryan D., Flynn, Daniel L.

“…Abstract Background: Mutations in the RAS/MAPK pathway are a frequent driver of cancer, with oncogenic RAS or RAF mutations occurring in >30% of all cancers…”
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