Search Results - "Prosser, H M"

Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem by Beale, KEL, Gardiner, JV, Bewick, GA, Hostomska, K, Patel, NA, Hussain, SS, Jayasena, CN, Ebling, FJP, Jethwa, PH, Prosser, HM, Lattanzi, R, Negri, L, Ghatei, MA, Bloom, SR, Dhillo, WS

“…Background and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors…”
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Genetic and molecular analysis of the central and peripheral circadian clockwork of mice by Maywood, E S, O'Neill, J S, Reddy, A B, Chesham, J E, Prosser, H M, Kyriacou, C P, Godinho, S I H, Nolan, P M, Hastings, M H

“…A hierarchy of interacting, tissue-based clocks controls circadian physiology and behavior in mammals. Preeminent are the suprachiasmatic nuclei (SCN): central…”
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A Phorbol Ester Response Element within the Human T-Cell Receptor β- Chain Enhancer by Prosser, Haydn M., Wotton, David, Gegonne, Anne, Ghysdael, Jacques, Wang, Shuwen, Speck, Nancy A., Owen, Michael J.

“…The activity of the T-cell receptor β-chain gene enhancer is increased by activators of the protein kinase C pathway during T-cell activation. Analysis of…”
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Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice by Prosser, H M, Gill, C H, Hirst, W D, Grau, E, Robbins, M, Calver, A, Soffin, E M, Farmer, C E, Lanneau, C, Gray, J, Schenck, E, Warmerdam, B S, Clapham, C, Reavill, C, Rogers, D C, Stean, T, Upton, N, Humphreys, K, Randall, A, Geppert, M, Davies, C H, Pangalos, M N

“…The recent cloning of two GABA(B) receptor subunits, GABA(B1) and GABA(B2), has raised the possibility that differences in GABA(B) receptor subunit composition…”
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Regulation of human T cell receptor beta gene expression by Ets-1 by Wotton, D, Prosser, H M, Owen, M J

“…Expression of the human TcR beta gene is controlled by an enhancer located 6kb 3' to the C beta 2 gene segment. The activity of this enhancer has been shown to…”
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Identification and functional analysis of the transcriptional enhancer of the human T cell receptor beta gene by Prosser, H M, Lake, R A, Wotton, D, Owen, M J

“…The productive rearrangement and transcription of T cell receptor (TcR) beta genes is confined to T lymphocytes and is subject to both tissue-specific and…”
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Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism by Jacobson, Samuel G., Cideciyan, Artur V., Aleman, Tomas S., Sumaroka, Alexander, Roman, Alejandro J., Gardner, Leigh M., Prosser, Haydn M., Mishra, Monalisa, Bech-Hansen, N. Torben, Herrera, Waldo, Schwartz, Sharon B., Liu, Xue-Zhong, Kimberling, William J., Steel, Karen P., Williams, David S.

“…Usher syndrome (USH) is a genetically heterogeneous group of autosomal recessive deaf-blinding disorders. Pathophysiology leading to the blinding retinal…”
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Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice by Viney, J L, Prosser, H M, Hewitt, C R, Lamb, J R, Owen, M J

“…The generation of a panel of monoclonal antibodies specific for different variable (V) regions of human T cell receptors will be of great importance in the…”
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TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers by Oosterwegel, M A, van de Wetering, M L, Holstege, F C, Prosser, H M, Owen, M J, Clevers, H C

“…We have recently identified and cloned TCF-1, a T cell-specific transcription factor with specificity for the AACAAAG motif in the CD3 epsilon enhancer and for…”
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Loss of prokineticin receptor 2 signaling predisposes mice to torpor by Jethwa, Preeti H, I'Anson, Helen, Warner, Amy, Prosser, Hayden M, Hastings, Michael H, Maywood, Elizabeth S, Ebling, Francis J P

“…The genes encoding prokineticin 2 polypeptide (Prok2) and its cognate receptor (Prokr2/Gpcr73l1) are widely expressed in both the suprachiasmatic nucleus and…”
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Epileptogenesis and Enhanced Prepulse Inhibition in GABA sub(B1)-Deficient Mice by Prosser, H M, Gill, CH, Hirst, W D, Grau, E, Robbins, M, Calver, A, Soffin, E M, Farmer, CE, Lanneau, C, Gray, J, Schenck, E, Warmerdam, B S, Clapham, C, Reavill, C, Rogers, D C, Stean, T, Upton, N, Humphreys, K, Randall, A, Geppert, M, Davies, CH, Pangalos, M N

“…The recent cloning of two GABA sub(B) receptor subunits, GABA sub(B1) and GABA sub(B2), has raised the possibility that differences in GABA sub(B) receptor…”
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Analysis of T cell repertoire and function in mice transgenic for the human V beta 3 TCR by Viney, J L, Prosser, H M, Palmer, D B, Lipoldová, M, Lamb, J R, Owen, M J

“…We have constructed mice containing the human V beta 3 TCR gene from the influenza virus haemagglutinin specific human CD4+ T cell clone HA1.7. Similar cell…”
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A phorbol ester response element within the human T-cell receptor β-chain enhancer by PROSSER, H. M, WOTTON, D, GEGONNE, A, GHYSDAEL, J, WANG, S, SPECK, N. A, OWEN, M. J

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Targeted replacement of rodent CCR2 with the human orthologue CCR2B: A mouse model for in vivo analysis of human target-selective small molecule MCP-1 receptor antagonists by Prosser, Haydn M., Cooper, David G., Forbes, Ian T., Geppert, Martin, Gribble, Andrew D., Grau, Evelyn V., Groot, Pieter H., Harper, Alex J., Moores, Kitty E., Pickering, Susan J., Piercy, Valerie

“…Rodent models for testing the efficacy of lead compounds are often invalidated by species selectivity of the compounds. The advent of mouse embryonic stem cell…”
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