Search Results - "Prospero, T"

"Diabodies": Small Bivalent and Bispecific Antibody Fragments by Holliger, Philipp, Prospero, Terence, Winter, Greg

“…Bivalent and bispecific antibodies and their fragments have immense potential for practical application. Here we describe the design of small antibody…”
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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo by Cobbold, S. P, Jayasuriya, A, Nash, A, Prospero, T. D, Waldmann, H

“…A major aim in immunology has been to understand how the immune system evokes characteristic responses to infection, foreign tissue grafts and tumours. The…”
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Isolation of high affinity human antibodies directly from large synthetic repertoires by Griffiths, A.D., Williams, S.C., Hartley, O., Tomlinson, I.M., Waterhouse, P., Crosby, W.L., Kontermann, R.E., Jones, P.T., Low, N.M., Allison, T.J.

“…Antibody fragments of moderate affinity (approximately microM) can be isolated from repertoires of approximately 10(8) immunoglobulin genes by phage display…”
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Glycosome Assembly in Trypanosomes: Variations in the Acceptable Degeneracy of a COOH-Terminal Microbody Targeting Signal by Blattner, Judith, Swinkels, Bart, Dörsam, Heinz, Prospero, Terry, Subramani, Suresh, Clayton, Christine

“…Trypanosomes compartmentalize most of their glycolytic enzymes in a peroxisome-like microbody, the glycosome. The specificity of glycosomal targeting was…”
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Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata by DOBBELAERE, D. A. E, PROSPERO, T. D, MORRISON, W. I, RODITI, I. J, KELKE, C, BAUMANN, I, EICHHORN, M, WILLIAMS, R. O, AHMED, J. S, BALDWIN, C. L, CLEVERS, H

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Different Roles for L3T4+ and Lyt 2+ T Cell Subsets in the Control of an Acute Herpes Simplex Virus Infection of the Skin and Nervous System by Nash, A. A, Jayasuriya, A, Phelan, J, Cobbold, S. P, Waldmann, H, Prospero, T

“…Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, U.K. Rat monoclonal antibodies were used to deplete selectively Lyt 2…”
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Multipurpose high sensitivity luminescence analyzer (LUANA): use in gel electrophoresis by Neri, D, Prospero, T, Petrul, H, Winter, G, Browne, M, Vanderpant, L

“…Many applications in molecular biology require the rapid and high-sensitivity detection of biological macromolecules. Here we describe a luminescence analyzer…”
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Antibodies against major histocompatibility complex class II antigens directly inhibit the growth of T cells infected with Theileria parva without affecting their state of activation by EICHHORN, M, PROSPERO, T. D, HEUSSLER, V. T, DOBBELAERE, D. A. E

“…We have analyzed the effect of antibodies (Abs) directed against major histocompatibility complex (MHC) class II Abs on the proliferation of Theileria…”
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DNA contents and molecular karyotypes of hybrid Trypanosoma brucei by Wells, J M, Prospero, T D, Jenni, L, Le Page, R W

“…We have used restriction fragment length polymorphism markers to characterise parental and hybrid trypanosome stocks. Unexpected differences in the intensities…”
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Dimerization of Fab fragments enables ready screening of phage antibodies that affect hepatocyte growth factor/scatter factor activity on target cells by Zaccolo, M, Griffiths, A P, Prospero, T D, Winter, G, Gherardi, E

“…A number of applications of antibodies in diagnosis and therapy require multivalent reagents either because of the polymeric nature of the antigens or because…”
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Characterization of events during the late stages of HPV16 infection in vivo using high-affinity synthetic Fabs to E4 by Doorbar, J, Foo, C, Coleman, N, Medcalf, L, Hartley, O, Prospero, T, Napthine, S, Sterling, J, Winter, G, Griffin, H

“…HPV late gene expression is initiated as an infected basal cell migrates through the differentiating layers of the epidermis, resulting in the onset of…”
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Phenotypic modulation of T-lymphoblastic leukaemic cells with phorbol ester and leucocyte conditioned medium by Chou, J L, Barker, C R, Prospero, T D

“…Human T-lymphoblastic leukaemic cell line Karpas-45 (K-45) can be induced by phorbol 12-myristate 13-acetate (PMA) to become phenotypically more mature. Marker…”
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The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells by Kabelitz, D, Bender, A, Prospero, T, Wesselborg, S, Janssen, O, Pechhold, K

“…We have previously reported that peripheral blood gamma/delta + T cells proliferate in high frequency (1 in 2-20) in response to heat-killed Mycobacterium…”
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Neuronal nuclei and glial nuclei from mammalian cerebral cortex: nucleosome repeat lengths, DNA contents and H1 contents by PEARSON, E. C, BATES, D. L, PROSPERO, T. D, THOMAS, J

“…We have characterised the histone and DNA contents of neuronal and glial nuclei from ox cerebral cortex which have, respectively, repeat lengths of 162 base…”
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Removal of T cells from bone marrow for transplantation. Comparison of rat monoclonal anti-lymphocyte antibodies of different isotypes by Hale, G, Hoang, T, Prospero, T, Watt, S M, Waldmann, H

“…We describe a family of six rat monoclonal antibodies which appear to recognize identical or closely related determinants present on virtually all mature human…”
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High-affinity Antigen Binding by Chelating Recombinant Antibodies (CRAbs) by Neri, Dario, Momo, Monica, Prospero, Terence, Winter, Greg

“…We have developed a strategy for making antibody fragments with high binding affinities by harnessing the chelate effect. We create a bispecific antibody…”
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T-lymphocyte and B-lymphocyte subpopulations infiltrating human mammary carcinomas by Eremin, O, Coombs, R R, Prospero, T D, Plumb, D

“…Both T- and B-lymphocytes were found in human primary mammary carcinomas and were distributed in widely varying amounts, but in most tumors, T-lymphocytes…”
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Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo by Hartmann, Guido, Prospero, Terence, Brinkmann, Volker, Ozcelik, Öemil, Winter, Greg, Hepple, Jonathan, Batley, Sarah, Bladt, Friedhelm, Sachs, Martin, Birchmeier, Carmen, Birchmeier, Walter, Gherardi, Ermanno

“…Background: Although a number of growth factors bind cell-surface heparan sulphate proteoglycans (HSPGs), the role of this interaction is unclear except for…”
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Identification of phenotypically distinct subpopulations of cytotoxic T lymphocytes by Zamoyska, R, Waldman, H, Prospero, T, Lennox, E

“…Two distinct subpopulations of cytotoxic T lymphocytes (CTL) were identified on the basis of their expression of a marker recognized by a monoclonal antibody…”
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The primary response of human γ/δ+ T cells to Mycobacterium tuberculosis is restricted to Vγ9-bearing cells by KABELITZ, D, BENDER, A, PROSPERO, T, WESSELBORG, S, JANSSEN, O, PECHHOLD, K

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