Search Results - "Prosise, W W"

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab by Scapin, Giovanna, Yang, Xiaoyu, Prosise, Winifred W, McCoy, Mark, Reichert, Paul, Johnston, Jennifer M, Kashi, Ramesh S, Strickland, Corey

“…IgG4 antibodies can exchange Fab arms and show different affinities for Fc receptors than do other IgG subclasses. The structure of full-length pembrolizumab,…”
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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase by Yao, Nanhua, Reichert, Paul, Taremi, S Shane, Prosise, Winifred W, Weber, Patricia C

“…Background: Hepatitis C virus (HCV) currently infects approximately 3% of the world's population. HCV RNA is translated into a polyprotein that during…”
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Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR by Xiao, Li, Nickbarg, Elliott, Wang, Wenyan, Thomas, Ann, Ziebell, Michael, Prosise, Winfred W., Lesburg, Charles A., Taremi, S. Shane, Gerlach, Valerie L., Le, Hung V., Cheng, K.-C.

“…3D structure of a tethered PXR–SRC peptide/SR12813. The pregnane X-receptor (PXR) is a promiscuous nuclear receptor primarily responsible for the induction of…”
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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization by Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent

“…The structures of both the native holo-HCV NS3/4A protease domain and the protease domain with a serine 139 to alanine (S139A) mutation were solved to high…”
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Crystal Structure of the Catalytic Domain of Human ADAM33 by Orth, Peter, Reichert, Paul, Wang, Wenyan, Prosise, Winifred W., Yarosh-Tomaine, Taisa, Hammond, Gerald, Ingram, Richard N., Xiao, Li, Mirza, Urooj A., Zou, Jun, Strickland, Corey, Taremi, S.Shane, Le, Hung V., Madison, Vincent

“…Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and…”
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Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability by Wang, Wenyan, Prosise, Winifred W., Chen, Jun, Taremi, S. Shane, Le, Hung V., Madison, Vincent, Cui, Xiaoming, Thomas, Ann, Cheng, K.-C., Lesburg, Charles A.

“…The nuclear xenobiotic receptor PXR is a ligand-inducible transcription factor regulating drug-metabolizing enzymes and transporters and a master switch…”
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A novel storage system for cryoEM samples by Scapin, Giovanna, Prosise, Winifred W., Wismer, Michael K., Strickland, Corey

“…We present here a new CryoEM grid boxes storage system designed to simplify sample labeling, tracking and retrieval. The system is based on the crystal pucks…”
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Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease by Taremi, S. Shane, Beyer, Brian, Maher, Maureen, Yao, Nanhua, Prosise, Winifred, Weber, Patricia C., Malcolm, Bruce A.

“…Efficient proteolytic processing of essential junctions of the hepatitis C virus (HCV) polyprotein requires a heterodimeric complex of the NS3 bifunctional…”
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A role for the carboxyl terminus of human granulocyte-macrophage colony-stimulating factor in the binding of ligand to the alpha-subunit of the high affinity receptor by SEELIG, G. F, PROSISE, W. W, SCHEFFLER, J. E

“…A synthetic segment (110-127) of the carboxyl terminus of recombinant human granulocyte-macrophage colony-stimulating factor (rh-GM-CSF) was used to generate a…”
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Protease domain of human ADAM33 produced by Drosophila S2 cells by Prosise, Winifred W., Yarosh-Tomaine, Taisa, Lozewski, Zia, Ingram, Richard N., Zou, Jun, Liu, Jian-Jun, Zhu, Feng, Taremi, S. Shane, Le, Hung V., Wang, Wenyan

“…Human ADAM33 is a multiple-domain, type-I transmembrane zinc metalloprotease recently implicated in asthma susceptibility [Nature 418 (2002) 426]. To provide…”
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Synthetic mimics of juxtaposed amino- and carboxyl-terminal peptide domains of human gamma interferon block ligand binding to human gamma interferon receptor by SEELIG, G. F, PROSISE, W. W, TAREMI, S. S

“…The epitopes of two neutralizing antibodies (47N3-6 and 47N30A35) raised against rhuIFN-gamma each mapped both to amino-terminal regions (22-29 and 12-19,…”
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Human Interleukin 4 Receptor Complex:  Neutralization Effect of Two Monoclonal Antibodies by Taremi, S. Shane, Prosise, Winifred W, Rajan, Nithya, O'Donnel, Rosemary A, Le, Hung V

“…The interaction of human interleukin 4 with the extracellular domain of its receptor α-subunit (shuIL-4Rα) was characterized in studies utilizing chemical…”
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Identification of Functionally Distinct Domains of Human Granulocyte-Macrophage Colony-Stimulating Factor Using Monoclonal Antibodies by Kanakura, Yuzuru, Cannistra, Stephen A., Brown, Christopher B., Nakamura, Masato, Seelig, Gail F., Prosise, Winifred W., Hawkins, Julio C., Kaushansky, Kenneth, Griffin, James D.

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that is required for the survival, growth, and differentiation of hematopoietic…”
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Development of a receptor peptide antagonist to human gamma-interferon and characterization of its ligand-bound conformation using transferred nuclear Overhauser effect spectroscopy by Seelig, G F, Prosise, W W, Hawkins, J C, Senior, M M

“…Polyclonal anti-idiotypic antibody raised to a synthetic discontinuous peptide derived from the human gamma-interferon (huIFN-gamma) sequence recognizes…”
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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034 by Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George

“…The structures of both native and S139A holo‐HCV NS3/4A protease domain were solved to high resolution. Subsequently, structures were determined for a series…”
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Development of a Receptor Peptide Antagonist to Human -Interferon and Characterization of Its Ligand-bound Conformation Using Transferred Nuclear Overhauser Effect Spectroscopy by Gail F. Seelig, Winifred W. Prosise, Julio C. Hawkins, Mary M. Senior

“…Polyclonal anti-idiotypic antibody raised to a synthetic discontinuous peptide derived from the human -interferon (huIFN- ) sequence recognizes soluble human…”
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Identification of functionally distinct domains of human granulocyte- macrophage colony-stimulating factor using monoclonal antibodies by Kanakura, Y, Cannistra, SA, Brown, CB, Nakamura, M, Seelig, GF, Prosise, WW, Hawkins, JC, Kaushansky, K, Griffin, JD

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that is required for the survival, growth, and differentiation of hematopoietic…”
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