Search Results - "Promislow, Daniel El"

Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast by Kaya, Alaattin, Phua, Cheryl Zi Jin, Lee, Mitchell, Wang, Lu, Tyshkovskiy, Alexander, Ma, Siming, Barre, Benjamin, Liu, Weiqiang, Harrison, Benjamin R, Zhao, Xiaqing, Zhou, Xuming, Wasko, Brian M, Bammler, Theo K, Promislow, Daniel El, Kaeberlein, Matt, Gladyshev, Vadim N

“…To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or…”
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Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice by Lyu, Yang, Weaver, Kristina J, Shaukat, Humza A, Plumoff, Marta L, Tjilos, Maria, Promislow, Daniel El, Pletcher, Scott D

“…It has been recognized for nearly a century that diet modulates aging. Despite early experiments suggesting that reduced caloric intake augmented lifespan,…”
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Cellular age explains variation in age-related cell-to-cell transcriptome variability by Yang, Ming, Harrison, Benjamin R, Promislow, Daniel E L

“…Organs and tissues age at different rates within a single individual. Such asynchrony in aging has been widely observed at multiple levels, from functional…”
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The dog aging project: translational geroscience in companion animals by Kaeberlein, Matt, Creevy, Kate E., Promislow, Daniel E. L.

“…Studies of the basic biology of aging have identified several genetic and pharmacological interventions that appear to modulate the rate of aging in laboratory…”
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Effects of age, sex, and genotype on high‐sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster by Hoffman, Jessica M., Soltow, Quinlyn A., Li, Shuzhao, Sidik, Alfire, Jones, Dean P., Promislow, Daniel E. L.

“…Summary Researchers have used whole‐genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the…”
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A Metabolomic Aging Clock Using Human Cerebrospinal Fluid by Hwangbo, Nathan, Zhang, Xinyu, Raftery, Daniel, Gu, Haiwei, Hu, Shu-Ching, Montine, Thomas J, Quinn, Joseph F, Chung, Kathryn A, Hiller, Amie L, Wang, Dongfang, Fei, Qiang, Bettcher, Lisa, Zabetian, Cyrus P, Peskind, Elaine, Li, Gail, Promislow, Daniel E L, Franks, Alexander

“…Abstract Quantifying the physiology of aging is essential for improving our understanding of age-related disease and the heterogeneity of healthy aging. Recent…”
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KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice by Gupta, Shweta, Moreno, Arturo J, Wang, Dan, Leon, Julio, Chen, Chen, Hahn, Oliver, Poon, Yan, Greenberg, Kenneth, David, Nathaniel, Wyss-Coray, Tony, Raftery, Daniel, Promislow, Daniel E L, Dubal, Dena B

“…Cognitive deficits are a major biomedical challenge-and engagement of the brain in stimulating tasks improves cognition in aged individuals (Wilson et al.,…”
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Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster by Landis, Gary N, Doherty, Devon V, Yen, Chia-An, Wang, Lu, Fan, Yang, Wang, Ina, Vroegop, Jonah, Wang, Tianyi, Wu, Jimmy, Patel, Palak, Lee, Shinwoo, Abdelmesieh, Mina, Shen, Jie, Promislow, Daniel E L, Curran, Sean P, Tower, John

“…Abstract Mating and transfer of male sex peptide (SP), or transgenic expression of SP, causes inflammation and decreased life span in female Drosophila…”
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Geographical Distribution and Diversity of Bacteria Associated with Natural Populations of Drosophila melanogaster by Corby-Harris, Vanessa, Pontaroli, Ana Clara, Shimkets, Lawrence J, Bennetzen, Jeffrey L, Habel, Kristin E, Promislow, Daniel E.L

“…Drosophila melanogaster is one of the most widely used model systems in biology. However, little is known about its associated bacterial community. As a first…”
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Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy by Nickel, Robert S., Osunkwo, Ifeyinwa, Garrett, Aneesah, Robertson, Jennifer, Archer, David R., Promislow, Daniel E.L., Horan, John T., Hendrickson, Jeanne E., Kean, Leslie S.

“…Summary Sickle cell disease (SCD) is increasingly appreciated as an inflammatory condition associated with alterations in immune phenotype and function. In…”
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Quantitative evidence for conserved longevity pathways between divergent eukaryotic species by Smith, Erica D, Tsuchiya, Mitsuhiro, Fox, Lindsay A, Dang, Nick, Hu, Di, Kerr, Emily O, Johnston, Elijah D, Tchao, Bie N, Pak, Diana N, Welton, K Linnea, Promislow, Daniel E L, Thomas, James H, Kaeberlein, Matt, Kennedy, Brian K

“…Studies in invertebrate model organisms have been a driving force in aging research, leading to the identification of many genes that influence life span. Few…”
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Metabolome-wide association study of phenylalanine in plasma of common marmosets by Go, Young-Mi, Walker, Douglas I., Soltow, Quinlyn A., Uppal, Karan, Wachtman, Lynn M., Strobel, Fredrick H., Pennell, Kurt, Promislow, Daniel E. L., Jones, Dean P.

“…Little systematic knowledge exists concerning the impacts of cumulative lifelong exposure, termed the exposome, on requirements for nutrients. Phenylalanine…”
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Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes by Lee, Mitchell B., Dowsett, Ian T., Carr, Daniel T., Wasko, Brian M., Stanton, Sarah G., Chung, Michael S., Ghodsian, Niloufar, Bode, Anna, Kiflezghi, Michael G., Uppal, Priya A., Grayden, Katherine A., Elala, Yordanos C., Tang, Thao T., Tran, Ngoc H. B., Tran, Thu H. B., Diep, Anh B., Hope, Michael, Promislow, Daniel E. L., Kennedy, Scott R., Kaeberlein, Matt, Herr, Alan J.

“…Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to…”
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Evolution of alternative sex-determining mechanisms in teleost fishes by MANK, JUDITH E., PROMISLOW, DANIEL E. L., AVISE, JOHN C.

“…We compiled information from the literature on the taxonomic distributions in extant teleost fishes of alternative sex‐determination systems:…”
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What can genetic variation tell us about the evolution of senescence? by Moorad, Jacob A., Promislow, Daniel E.L.

“…Quantitative genetic approaches have been developed that allow researchers to determine which of two mechanisms, mutation accumulation (MA) or antagonistic…”
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The functional costs and benefits of dietary restriction in Drosophila by Burger, Joep M. S., Hwangbo, Dae Sung, Corby‐Harris, Vanessa, Promislow, Daniel E. L.

“…Summary Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively…”
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Evolutionary demography and quantitative genetics: age-specific survival as a threshold trait by Moorad, Jacob A., Promislow, Daniel E. L.

“…Researchers must understand how mutations affect survival at various ages to understand how ageing evolves. Many models linking mutation to age-specific…”
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Functional and evolutionary inference in gene networks: does topology matter by Siegal, Mark L, Promislow, Daniel E. L, Bergman, Aviv

“…The relationship between the topology of a biological network and its functional or evolutionary properties has attracted much recent interest. It has been…”
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Purpose, Partnership, and Possibilities: The Implementation of the Dog Aging Project Biobank by Mouttham, Lara, Castelhano, Marta G, Akey, Joshua M, Benton, Brooke, Borenstein, Elhanan, Castelhano, Marta G, Coleman, Amanda E, Creevy, Kate E, Crowder, Kyle, Dunbar, Matthew D, Ernst, Holley R, Fajt, Virginia R, Fitzpatrick, Annette L, Garrison, Susan J, Herndon, Reba S, Jaramilla, Debra, Jeffery, Unity, Jonlin, Erica C, Kaeberlein, Matt, Karlsson, Elinor K, Kerr, Kathleen F, Levine, Jonathan M, Ma, Jing, McClelland, Robyn L, Prescott, Jena O, Promislow, Daniel EL, Ruple, Audrey, Schwartz, Stephen M, Shrager, Sandi, Snyder-Mackler, Noah, Tinkle, Amanda K, Tolbert, M Katherine, Urfer, Silvan R, Wilfond, Benjamin S

“…Background: Biobanks have been supporting longitudinal prospective and retrospective studies by providing standardized services for the acquisition, transport,…”
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Invariance and plasticity in the Drosophila melanogastermetabolomic network in response to temperature by Hariharan, Ramkumar, Hoffman, Jessica M, Thomas, Ariel S, Soltow, Quinlyn A, Jones, Dean P, Promislow, Daniel EL

“…Metabolomic responses to extreme thermal stress have recently been investigated in Drosophila melanogaster. However, a network level understanding of…”
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