Search Results - "Prokopenko, Polina"

A novel immunofluorescent test system for SARS-CoV-2 detection in infected cells by Rak, Alexandra, Matyushenko, Victoria, Prokopenko, Polina, Kostromitina, Arina, Polyakov, Dmitry, Sokolov, Alexey, Rudenko, Larisa, Isakova-Sivak, Irina

“…Highly variable pandemic coronavirus SARS-CoV-2, which causes the hazardous COVID-19 infection, has been persistent in the human population since late 2019. A…”
Get full text

Assessment of Immunogenic and Antigenic Properties of Recombinant Nucleocapsid Proteins of Five SARS-CoV-2 Variants in a Mouse Model by Rak, Alexandra, Gorbunov, Nikolay, Kostevich, Valeria, Sokolov, Alexey, Prokopenko, Polina, Rudenko, Larisa, Isakova-Sivak, Irina

“…COVID-19 cases caused by new variants of highly mutable SARS-CoV-2 continue to be identified worldwide. Effective control of the spread of new variants can be…”
Get full text

Detection of IFNγ-Secreting CD4+ and CD8+ Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2 by Matyushenko, Victoria, Isakova-Sivak, Irina, Kudryavtsev, Igor, Goshina, Arina, Chistyakova, Anna, Stepanova, Ekaterina, Prokopenko, Polina, Sychev, Ivan, Rudenko, Larisa

“…Background: New coronavirus SARS-CoV-2, a causative agent of the COVID-19 pandemic, has been circulating among humans since November 2019. Multiple studies…”
Get full text

Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza by Stepanova, Ekaterina, Isakova-Sivak, Irina, Mezhenskaya, Daria, Niskanen, Sergei, Matyushenko, Victoria, Bazhenova, Ekaterina, Rak, Alexandra, Wong, Pei Fong, Prokopenko, Polina, Kotomina, Tatiana, Krutikova, Elena, Legotskiy, Sergei, Neterebskii, Bogdan, Ostroukhova, Tatiana, Sivak, Konstantin, Orshanskaya, Yana, Yakovlev, Kirill, Rudenko, Larisa

“…Influenza and SARS-CoV-2 are two major respiratory pathogens that cocirculate in humans and cause serious illness with the potential to exacerbate disease in…”
Get full text

Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site by Kotomina, Tatiana, Korenkov, Daniil, Matyushenko, Victoria, Prokopenko, Polina, Rudenko, Larisa, Isakova-Sivak, Irina

“…The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a…”
Get full text

Truncation of NS1 Protein Enhances T Cell-Mediated Cross-Protection of a Live Attenuated Influenza Vaccine Virus Expressing Wild-Type Nucleoprotein by Prokopenko, Polina, Matyushenko, Victoria, Rak, Alexandra, Stepanova, Ekaterina, Chistyakova, Anna, Goshina, Arina, Kudryavtsev, Igor, Rudenko, Larisa, Isakova-Sivak, Irina

“…Current seasonal influenza vaccines have suboptimal effectiveness, especially in seasons dominated by viruses that do not match the vaccine. Therefore, finding…”
Get full text

Development of a T Cell-Based COVID-19 Vaccine Using a Live Attenuated Influenza Vaccine Viral Vector by Isakova-Sivak, Irina, Stepanova, Ekaterina, Matyushenko, Victoria, Niskanen, Sergei, Mezhenskaya, Daria, Bazhenova, Ekaterina, Krutikova, Elena, Kotomina, Tatiana, Prokopenko, Polina, Neterebskii, Bogdan, Doronin, Aleksandr, Vinogradova, Elena, Yakovlev, Kirill, Sivak, Konstantin, Rudenko, Larisa

“…The COVID-19 pandemic emerged in 2020 and has caused an unprecedented burden to all countries in the world. SARS-CoV-2 continues to circulate and antigenically…”
Get full text

Safety and Immunogenicity Study of a Bivalent Vaccine for Combined Prophylaxis of COVID-19 and Influenza in Non-Human Primates by Stepanova, Ekaterina, Isakova-Sivak, Irina, Matyushenko, Victoria, Mezhenskaya, Daria, Kudryavtsev, Igor, Kostromitina, Arina, Chistiakova, Anna, Rak, Alexandra, Bazhenova, Ekaterina, Prokopenko, Polina, Kotomina, Tatiana, Donina, Svetlana, Novitskaya, Vlada, Sivak, Konstantin, Karal-Ogly, Dzhina, Rudenko, Larisa

“…Influenza and SARS-CoV-2 viruses are two highly variable pathogens. We have developed a candidate bivalent live vaccine based on the strain of licensed…”
Get full text

Recombinant Live Attenuated Influenza Vaccine Viruses Carrying Conserved T-cell Epitopes of Human Adenoviruses Induce Functional Cytotoxic T-Cell Responses and Protect Mice against Both Infections by Isakova-Sivak, Irina, Matyushenko, Victoria, Stepanova, Ekaterina, Matushkina, Anastasia, Kotomina, Tatiana, Mezhenskaya, Daria, Prokopenko, Polina, Kudryavtsev, Igor, Kopeykin, Pavel, Sivak, Konstantin, Rudenko, Larisa

“…Human adenoviruses (AdVs) are one of the most common causes of acute respiratory viral infections worldwide. Multiple AdV serotypes with low cross-reactivity…”
Get full text

Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses by Matyushenko, Victoria, Kotomina, Tatiana, Kudryavtsev, Igor, Mezhenskaya, Daria, Prokopenko, Polina, Matushkina, Anastasia, Sivak, Konstantin, Muzhikyan, Arman, Rudenko, Larisa, Isakova-Sivak, Irina

“…Respiratory syncytial virus (RSV) can cause recurrent infection in people because it does not stimulate a long-lived immunological memory. There is an urgent…”
Get full text

Influenza vaccine: progress in a vaccine that elicits a broad immune response by Isakova-Sivak, Irina, Stepanova, Ekaterina, Mezhenskaya, Daria, Matyushenko, Victoria, Prokopenko, Polina, Sychev, Ivan, Wong, Pei-Fong, Rudenko, Larisa

“…The licensed seasonal influenza vaccines predominantly induce neutralizing antibodies against immunodominant hypervariable epitopes of viral surface proteins,…”
Get more information

Enhancement of systemic and lung-localized CD4+ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain by Prokopenko, Polina I., Stepanova, Ekaterina A., Matyushenko, Victoria A., Rak, Alexandra Ya, Chistyakova, Anna K., Kostromitina, Arina D., Kotomina, Tatyana S., Kudryavtsev, Igor V., Rubinstein, Artem A., Komlev, Alexey S., Rudenko, Larisa G., Isakova-Sivak, Irina N.

“…Introduction. There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to…”
Get full text

Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters by Stepanova, Ekaterina, Matyushenko, Victoria, Mezhenskaya, Daria, Bazhenova, Ekaterina, Kotomina, Tatiana, Rak, Alexandra, Donina, Svetlana, Chistiakova, Anna, Kostromitina, Arina, Novitskaya, Vlada, Prokopenko, Polina, Rodionova, Kristina, Sivak, Konstantin, Kryshen, Kirill, Makarov, Valery, Rudenko, Larisa, Isakova-Sivak, Irina

“…Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, and both pathogens are characterized by a high…”
Get full text

Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site by Kotomina, Tatiana, Korenkov, Daniil, Matyushenko, Victoria, Prokopenko, Polina, Rudenko, Larisa, Isakova-Sivak, Irina

“…The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a…”
Get full text