Search Results - "Prokop, W"

Occupancy maps of 208 chromatin-associated proteins in one human cell type by Partridge, E. Christopher, Chhetri, Surya B., Prokop, Jeremy W., Ramaker, Ryne C., Jansen, Camden S., Goh, Say-Tar, Mackiewicz, Mark, Newberry, Kimberly M., Brandsmeier, Laurel A., Meadows, Sarah K., Messer, C. Luke, Hardigan, Andrew A., Coppola, Candice J., Dean, Emma C., Jiang, Shan, Savic, Daniel, Mortazavi, Ali, Wold, Barbara J., Myers, Richard M., Mendenhall, Eric M.

“…Transcription factors are DNA-binding proteins that have key roles in gene regulation 1 , 2 . Genome-wide occupancy maps of transcriptional regulators are…”
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Performance of single-use syringe versus multi-use MR contrast injectors: a prospective comparative study by Struik, F., Futterer, J. J., Prokop, W. M.

“…The goal of this study was to compare performance parameters of a single-use syringe and a multi-use MR contrast injector. We compared preparation time, cost…”
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Genome sequencing in the clinic: the past, present, and future of genomic medicine by Prokop, Jeremy W, May, Thomas, Strong, Kim, Bilinovich, Stephanie M, Bupp, Caleb, Rajasekaran, Surender, Worthey, Elizabeth A, Lazar, Jozef

“…Genomic sequencing has undergone massive expansion in the past 10 yr, from a rarely used research tool into an approach that has broad applications in a…”
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Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor by Prokop, Jeremy W, Schmidt, Cameron, Gasper, Donald, Duff, Robert J, Milsted, Amy, Ohkubo, Takeshi, Ball, Hope C, Shawkey, Matthew D, Mays, Jr, Herman L, Cogburn, Larry A, Londraville, Richard L

“…Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among…”
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Dilated coronary arteries in a 2-month-old with RIT1-associated Noonan syndrome: a case report by Aniol, Claudia V, Prokop, Jeremy W, Rajasekaran, Surender, Pageau, Spencer, Elizer, Sydney K, VanSickle, Elizabeth A, Bupp, Caleb P

“…Noonan Syndrome is caused by variants in a variety of genes found in the RAS/MAPK pathway. As more causative genes for Noonan Syndrome have been identified,…”
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Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B by Wilson, Jessica M., Prokop, Jeremy W., Lorimer, Ellen, Ntantie, Elizabeth, Williams, Carol L.

“…Two isoforms of the small GTPase Rap1, Rap1A and Rap1B, participate in cell adhesion; Rap1A promotes steady state adhesion, while Rap1B regulates dynamic…”
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Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease by Rajasekaran, Surender, Bupp, Caleb P, Leimanis-Laurens, Mara, Shukla, Ankit, Russell, Christopher, Junewick, Joseph, Gleason, Emily, VanSickle, Elizabeth A, Edgerly, Yvonne, Wittmann, Bryan M, Prokop, Jeremy W, Bachmann, André S

“…Polyamine levels are intricately controlled by biosynthetic, catabolic enzymes and antizymes. The complexity suggests that minute alterations in levels lead to…”
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High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals by Prokop, Jeremy W, Hartog, Nicholas L, Chesla, Dave, Faber, William, Love, Chanise P, Karam, Rachid, Abualkheir, Nelly, Feldmann, Benjamin, Teng, Li, McBride, Tamara, Leimanis, Mara L, English, B Keith, Holsworth, Amanda, Frisch, Austin, Bauss, Jacob, Kalpage, Nathisha, Derbedrossian, Aram, Pinti, Ryan M, Hale, Nicole, Mills, Joshua, Eby, Alexandra, VanSickle, Elizabeth A, Pageau, Spencer C, Shankar, Rama, Chen, Bin, Carcillo, Joseph A, Sanfilippo, Dominic, Olivero, Rosemary, Bupp, Caleb P, Rajasekaran, Surender

“…The immune response to COVID-19 infection is variable. How COVID-19 influences clinical outcomes in hospitalized patients needs to be understood through…”
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PEA15 loss of function and defective cerebral development in the domestic cat by Graff, Emily C, Cochran, J Nicholas, Kaelin, Christopher B, Day, Kenneth, Gray-Edwards, Heather L, Watanabe, Rie, Koehler, Jey W, Falgoust, Rebecca A, Prokop, Jeremy W, Myers, Richard M, Cox, Nancy R, Barsh, Gregory S, Martin, Douglas R

“…Cerebral cortical size and organization are critical features of neurodevelopment and human evolution, for which genetic investigation in model organisms can…”
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Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model by Keele, Gregory R., Prokop, Jeremy W., He, Hong, Holl, Katie, Littrell, John, Deal, Aaron W., Kim, Yunjung, Kyle, Patrick B., Attipoe, Esinam, Johnson, Ashley C., Uhl, Katie L., Sirpilla, Olivia L., Jahanbakhsh, Seyedehameneh, Robinson, Melanie, Levy, Shawn, Valdar, William, Garrett, Michael R., Solberg Woods, Leah C.

“…Chronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome…”
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Pricing and cost-saving potential for deep-learning computer-aided lung nodule detection software in CT lung cancer screening by Du, Yihui, Greuter, Marcel J. W., Prokop, Mathias W., de Bock, Geertruida H.

“…Objective An increasing number of commercial deep learning computer-aided detection (DL-CAD) systems are available but their cost-saving potential is largely…”
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ProPSA and the Prostate Health Index as predictive markers for aggressiveness in low-risk prostate cancer—results from an international multicenter study by Heidegger, I, Klocker, H, Pichler, R, Pircher, A, Prokop, W, Steiner, E, Ladurner, C, Comploj, E, Lunacek, A, Djordjevic, D, Pycha, A, Plas, E, Horninger, W, Bektic, J

“…Background: One of the major challenges in prostate cancer (PCa) treatment is distinguishing insignificant PCa from those forms that need active treatment. We…”
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Pediatric Multi-Organ Dysfunction Syndrome: Analysis by an Untargeted "Shotgun" Lipidomic Approach Reveals Low-Abundance Plasma Phospholipids and Dynamic Recovery over 8-Day Period, a Single-Center Observational Study by Leimanis-Laurens, Mara L, Ferguson, Karen, Wolfrum, Emily, Boville, Brian, Sanfilippo, Dominic, Lydic, Todd A, Prokop, Jeremy W, Rajasekaran, Surender

“…Lipids are molecules involved in metabolism and inflammation. This study investigates the plasma lipidome for markers of severity and nutritional status in…”
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CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications by Bauss, Jacob, Morris, Michele, Shankar, Rama, Olivero, Rosemary, Buck, Leah N, Stenger, Cynthia L, Hinds, David, Mills, Joshua, Eby, Alexandra, Zagorski, Joseph W, Smith, Caitlin, Cline, Sara, Hartog, Nicholas L, Chen, Bin, Huss, John, Carcillo, Joseph A, Rajasekaran, Surender, Bupp, Caleb P, Prokop, Jeremy W

“…In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and…”
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Structure-Function of the Human WAC Protein in GABAergic Neurons: Towards an Understanding of Autosomal Dominant DeSanto-Shinawi Syndrome by Rudolph, Hannah C, Stafford, April M, Hwang, Hye-Eun, Kim, Cheol-Hee, Prokop, Jeremy W, Vogt, Daniel

“…Dysfunction of the WW domain-containing adaptor with coiled-coil, , gene underlies a rare autosomal dominant disorder, DeSanto-Shinawi syndrome (DESSH). DESSH…”
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Understanding Insulin in the Age of Precision Medicine and Big Data: Under-Explored Nature of Genomics by Cook, Taylor W, Wilstermann, Amy M, Mitchell, Jackson T, Arnold, Nicholas E, Rajasekaran, Surender, Bupp, Caleb P, Prokop, Jeremy W

“…Insulin is amongst the human genome's most well-studied genes/proteins due to its connection to metabolic health. Within this article, we review literature and…”
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Gene expression signatures identify paediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unit by Shankar, Rama, Leimanis, Mara L., Newbury, Patrick A., Liu, Ke, Xing, Jing, Nedveck, Derek, Kort, Eric J., Prokop, Jeremy W, Zhou, Guoli, Bachmann, André S, Chen, Bin, Rajasekaran, Surender

“…Multiple organ dysfunction syndrome (MODS) occurs in the setting of a variety of pathologies including infection and trauma. Some patients decompensate and…”
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Methylation specific targeting of a chromatin remodeling complex from sponges to humans by Cramer, Jason M., Pohlmann, Deborah, Gomez, Fernando, Mark, Leslie, Kornegay, Benjamin, Hall, Chelsea, Siraliev-Perez, Edhriz, Walavalkar, Ninad M., Sperlazza, M. Jeannette, Bilinovich, Stephanie, Prokop, Jeremy W., Hill, April L., Williams Jr, David C.

“…DNA cytosine methylation and methyl-cytosine binding domain (MBD) containing proteins are found throughout all vertebrate species studied to date. However,…”
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Familial hypercholesterolaemia in patients with ischaemic stroke or transient ischaemic attack by Toell, T., Mayer, L., Pechlaner, R., Krebs, S., Willeit, K., Lang, C., Boehme, C., Prantl, B., Knoflach, M., Ferrari, J., Fuchs, P., Prokop, W., Griesmacher, A., Lang, W., Kiechl, S., Willeit, J.

“…Background and purpose Identification of patients with familial hypercholesterolaemia (FH) is a prerequisite for the appropriate management of their excess…”
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Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales by Ball, H. C., Londraville, R. L., Prokop, J. W., George, John C., Suydam, R. S., Vinyard, C., Thewissen, J. G. M., Duff, R. J.

“…The processes of lipid deposition and utilization, via the gene leptin ( Lep ), are poorly understood in taxa with varying degrees of adipose storage. This…”
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