Prevalence of hepatitis E markers in children

Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status. The presence of HEV markers (anti-HEV IgG and IgM, HEV RNA) was studied in 609 sera samples of children with neurolo...

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Published in:	Žurnal mikrobiologii, ėpidemiologii i immunobiologii Vol. 92; no. 2; pp. 38 - 46
Main Authors:	Potemkin, I A, Lopatukhina, M A, Gadzhieva, O A, Prokhorova, E L, Diyarrassuba, A, Isaeva, O A, Kozhanova, T V, Ivanova, O E, Silenova, O V, Setdikova, N Kh, Kyuregyan, K K, Mikhailov, M I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) Central Research Institute for Epidemiology 01-03-2015
Subjects:	Acute Disease Adolescent anti-hev Child Child, Preschool Female Hepatitis Antibodies - blood hepatitis e Hepatitis E - blood Hepatitis E - epidemiology Hepatitis E - immunology Hepatitis E - virology Hepatitis E virus - classification Hepatitis E virus - genetics Hepatitis E virus - isolation & purification Humans immune suppression Immunocompromised Host Immunoglobulin G - blood Immunoglobulin M - blood Infant Infant, Newborn Male Phylogeny Prevalence RNA, Viral - blood Russia - epidemiology Sequence Analysis, RNA Young Adult Russia
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Summary:	Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status. The presence of HEV markers (anti-HEV IgG and IgM, HEV RNA) was studied in 609 sera samples of children with neurologic pathologies, 87 samples--from children with immune deficiencies, as well as 3122 samples from conditionally healthy children of 6 regions of Russia. The children were divided into 5 age groups. Anti-HEV IgG and IgM determination was carried out in EIA, HEV RNA--by RT-PCR. The frequency of detection of anamnestic anti-HEV IgG turned out to be significantly higher among immune-compromised. children compared with healthy children (5.7% against 1.4%, p < 0.05). Anti-HEV IgM, that testify to current or recent infection, were also detected significantly more frequently among children with immune-suppression (1.1-1.6%) compared with healthy children (0.25%, p < 0.05). HEV RNA was detected in 1 child with the absence of anti-HEV IgM and IgG. Nucleotide sequence analysis of HEV confirmed membership of this isolate in genotype 3, that is prevalent in non-endemic territories. The data obtained have demonstrated, that HEV-infection is prevalent among children in Russia and its course is, probably, asymptomatic in most cases. Immune suppression is a factor of increased risk of infection of children with HEV.
ISSN:	0372-9311 2686-7613