Search Results - "Proietti, Enrico"

Immunomodulatory effects of cyclophosphamide and implementations for vaccine design by Sistigu, Antonella, Viaud, Sophie, Chaput, Nathalie, Bracci, Laura, Proietti, Enrico, Zitvogel, Laurence

“…Drug repositioning refers to the utilization of a known compound in a novel indication underscoring a new mode of action that predicts innovative therapeutic…”
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Nicotinamide inhibits melanoma in vitro and in vivo by Scatozza, Francesca, Moschella, Federica, D'Arcangelo, Daniela, Rossi, Stefania, Tabolacci, Claudio, Giampietri, Claudia, Proietti, Enrico, Facchiano, Francesco, Facchiano, Antonio

“…Abstract Background Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In…”
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Type I interferons induce peripheral T regulatory cell differentiation under tolerogenic conditions by Vitale, Sara, Russo, Valentina, Dettori, Beatrice, Palombi, Cecilia, Baev, Denis, Proietti, Enrico, Le Bon, Agnes, Belardelli, Filippo, Pace, Luigia

“…Abstract The type I interferons are central to a vast array of immunological functions. The production of these immune-modulatory molecules is initiated at the…”
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Cyclophosphamide Induces a Type I Interferon―Associated Sterile Inflammatory Response Signature in Cancer Patients' Blood Cells: Implications for Cancer Chemoimmunotherapy by MOSCHELLA, Federica, TORELLI, Giovanni Fernando, VALENTINI, Mara, URBANI, Francesca, BUCCIONE, Carla, PETRUCCI, Maria Teresa, NATALINO, Fiammetta, BELARDELLI, Filippo, FOA, Robin, PROIETTI, Enrico

“…Certain chemotherapeutics, particularly cyclophosphamide, can enhance the antitumor efficacy of immunotherapy. A better understanding of the cellular and…”
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Cyclophosphamide Enhances the Antitumor Efficacy of Adoptively Transferred Immune Cells through the Induction of Cytokine Expression, B-Cell and T-Cell Homeostatic Proliferation, and Specific Tumor Infiltration by BRACCI, Laura, MOSCHELLA, Federica, PROIETTI, Enrico, SESTILI, Paola, LA SORSA, Valentina, VALENTINI, Mara, CANINI, Irene, BACCARINI, Sara, MACCARI, Sonia, RAMONI, Carlo, BELARDELLI, Filippo

“…Purpose: Immunotherapy is a promising antitumor strategy, which can be successfully combined with current anticancer treatments, as suggested by recent studies…”
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Blood immune cells as potential biomarkers predicting relapse-free survival of stage III/IV resected melanoma patients treated with peptide-based vaccination and interferon-alpha by Moschella, Federica, Buccione, Carla, Ruspantini, Irene, Castiello, Luciano, Rozo Gonzalez, Andrea, Iacobone, Floriana, Ferraresi, Virginia, Palermo, Belinda, Nisticò, Paola, Belardelli, Filippo, Proietti, Enrico, Macchia, Iole, Urbani, Francesca

“…Despite the recent approval of several therapies in the adjuvant setting of melanoma, tumor relapse still occurs in a significant number of completely resected…”
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Unraveling Cancer Chemoimmunotherapy Mechanisms by Gene and Protein Expression Profiling of Responses to Cyclophosphamide by MOSCHELLA, Federica, VALENTINI, Mara, ARICO, Eleonora, MACCHIA, Lole, SESTILI, Paola, TERESA D'URSO, Maria, ALESSANDRI, Cristiano, BELARDELLI, Filippo, PROIETTI, Enrico

“…Certain chemotherapeutic drugs, such as cyclophosphamide (CTX), can enhance the antitumor efficacy of immunotherapy because of their capacity to modulate…”
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Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells by Castiello, Luciano, Sestili, Paola, Schiavoni, Giovanna, Dattilo, Rosanna, Monque, Domenica M, Ciaffoni, Fiorella, Iezzi, Manuela, Lamolinara, Alessia, Sistigu, Antonella, Moschella, Federica, Pacca, Anna Maria, Macchia, Daniele, Ferrantini, Maria, Zeuner, Ann, Biffoni, Mauro, Proietti, Enrico, Belardelli, Filippo, Aricò, Eleonora

“…Type I interferon (IFN-I) is a class of antiviral immunomodulatory cytokines involved in many stages of tumor initiation and progression. IFN-I acts directly…”
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Cancer bio-immunotherapy XVI annual NIBIT-(Italian Network for Tumor Biotherapy) meeting, October 11–13 2018, Milan, Italy by Bellone, Matteo, Brevi, Arianna, Bruzzì, Stefania, Consonni, Michela, De Santis, Francesca, Di Lullo, Giulia, Majorini, Maria Teresa, Pastò, Anna, Amadori, Alberto, Bregni, Marco, Di Nicola, Massimo, Calabrò, Luana, Ferrucci, Pier Francesco, Proietti, Enrico, Colombo, Mario Paolo, Russo, Vincenzo

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Interferon-alpha in tumor immunity and immunotherapy by Belardelli, Filippo, Ferrantini, Maria, Proietti, Enrico, Kirkwood, John M

“…Interferon-alpha (IFN-α) is a pleiotropic cytokine belonging to type I IFN, currently used in cancer patients. Early studies in mouse tumor models have shown…”
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Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma by Rozera, Carmela, Cappellini, Giancarlo Antonini, D'Agostino, Giuseppina, Santodonato, Laura, Castiello, Luciano, Urbani, Francesca, Macchia, Iole, Aricò, Eleonora, Casorelli, Ida, Sestili, Paola, Montefiore, Enrica, Monque, Domenica, Carlei, Davide, Napolitano, Mariarosaria, Rizza, Paola, Moschella, Federica, Buccione, Carla, Belli, Roberto, Proietti, Enrico, Pavan, Antonio, Marchetti, Paolo, Belardelli, Filippo, Capone, Imerio

“…Advanced melanoma patients have an extremely poor long term prognosis and are in strong need of new therapies. The recently developed targeted therapies have…”
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Antigen-specificity and DTIC before peptide-vaccination differently shape immune-checkpoint expression pattern, anti-tumor functionality and TCR repertoire in melanoma patients by Palermo, Belinda, Franzese, Ornella, Donna, Cosmo Di, Panetta, Mariangela, Quintarelli, Concetta, Sperduti, Isabella, Gualtieri, Novella, Foddai, Maria Laura, Proietti, Enrico, Ferraresi, Virginia, Ciliberto, Gennaro, Nisticò, Paola

“…We have recently described that DNA-damage inducing drug DTIC, administered before peptide (Melan-A and gp100)-vaccination, improves anti-tumor CD8 +…”
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Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study by Urbani, Francesca, Ferraresi, Virginia, Capone, Imerio, Macchia, Iole, Palermo, Belinda, Nuzzo, Carmen, Torsello, Angela, Pezzotti, Patrizio, Giannarelli, Diana, Pozzi, Anna Fausta, Santaquilani, Mariano, Roazzi, Paolo, Bastucci, Silvia, Catricalà, Caterina, La Malfa, Antonia, Vercillo, Giuseppe, Gualtieri, Novella, Buccione, Carla, Castiello, Luciano, Cognetti, Francesco, Nisticò, Paola, Belardelli, Filippo, Moschella, Federica, Proietti, Enrico

“…Clinical studies based on novel rationales and mechanisms of action of chemotherapy agents and cytokines can contribute to the development of new concepts and…”
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Tumor-Intrinsic or Drug-Induced Immunogenicity Dictates the Therapeutic Success of the PD1/PDL Axis Blockade by Rossi, Alessandra, Lucarini, Valeria, Macchia, Iole, Sestili, Paola, Buccione, Carla, Donati, Simona, Ciccolella, Maria, Sistigu, Antonella, D'Urso, Maria Teresa, Pacca, Anna Maria, Cardarelli, Enrico, Mattei, Fabrizio, Proietti, Enrico, Schiavoni, Giovanna, Bracci, Laura

“…Immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment providing unprecedented clinical benefits. However, many patients do…”
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Type I IFN as a Natural Adjuvant for a Protective Immune Response: Lessons from the Influenza Vaccine Model by Proietti, Enrico, Bracci, Laura, Puzelli, Simona, Di Pucchio, Tiziana, Sestili, Paola, De Vincenzi, Enrico, Venditti, Massimo, Capone, Imerio, Seif, Isabelle, De Maeyer, Edward, Tough, David, Donatelli, Isabella, Belardelli, Filippo

“…The identification of natural adjuvants capable of selectively promoting an efficient immune response against infectious agents would represent an important…”
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Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level by Bracci, Laura, Canini, Irene, Puzelli, Simona, Sestili, Paola, Venditti, Massimo, Spada, Massimo, Donatelli, Isabella, Belardelli, Filippo, Proietti, Enrico

“…In view of the increasing interest in mucosal vaccination, we investigated whether type I IFN could act as adjuvant of an intranasally administered influenza…”
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Twenty-five years of type I interferon-based treatment: A critical analysis of its therapeutic use by Antonelli, Guido, Scagnolari, Carolina, Moschella, Federica, Proietti, Enrico

“…Abstract The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this…”
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Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis by SCHIAVONI, Giovanna, SISTIGU, Antonella, GABRIELE, Lucia, PROIETTI, Enrico, BRACCI, Laura, VALENTINI, Mara, MATTEI, Fabrizio, SESTILI, Paola, SPADARO, Francesca, SANCHEZ, Massimo, LORENZI, Silvia, D'URSO, Maria Teresa, BELARDELLI, Filippo

“…Successful chemotherapy accounts for both tumor-related factors and host immune response. Compelling evidence suggests that some chemotherapeutic agents can…”
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The added value of type i interferons to cytotoxic treatments of cancer by Bracci, Laura, Sistigu, Antonella, Proietti, Enrico, Moschella, Federica

“…Highlights • The therapeutic efficacy of some conventional chemotherapeutics, target therapies and radiotherapy relies not only on direct cytotoxicity but also…”
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Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy by Sistigu, Antonella, Yamazaki, Takahiro, Vacchelli, Erika, Chaba, Kariman, Enot, David P, Adam, Julien, Vitale, Ilio, Goubar, Aicha, Baracco, Elisa E, Remédios, Catarina, Fend, Laetitia, Hannani, Dalil, Aymeric, Laetitia, Ma, Yuting, Niso-Santano, Mireia, Kepp, Oliver, Schultze, Joachim L, Tüting, Thomas, Belardelli, Filippo, Bracci, Laura, La Sorsa, Valentina, Ziccheddu, Giovanna, Sestili, Paola, Urbani, Francesca, Delorenzi, Mauro, Lacroix-Triki, Magali, Quidville, Virginie, Conforti, Rosa, Spano, Jean-Philippe, Pusztai, Lajos, Poirier-Colame, Vichnou, Delaloge, Suzette, Penault-Llorca, Frederique, Ladoire, Sylvain, Arnould, Laurent, Cyrta, Joanna, Dessoliers, Marie-Charlotte, Eggermont, Alexander, Bianchi, Marco E, Pittet, Mikael, Engblom, Camilla, Pfirschke, Christina, Préville, Xavier, Uzè, Gilles, Schreiber, Robert D, Chow, Melvyn T, Smyth, Mark J, Proietti, Enrico, André, Fabrice, Kroemer, Guido, Zitvogel, Laurence

“…Anthracyclines can induce a type 1 interferon response in tumor cells that may predict clinical response to these drugs. Some of the anti-neoplastic effects of…”
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