Search Results - "Prohens, Llucia"
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Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia
Published in Progress in neuro-psychopharmacology & biological psychiatry (20-04-2024)“…Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating the negative and cognitive symptoms. The SZ…”
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Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data
Published in Frontiers in pharmacology (13-08-2021)“…Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia and metabolic syndrome. This…”
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Gene expression imputation provides clinical and biological insights into treatment-resistant schizophrenia polygenic risk
Published in Psychiatry research (01-02-2024)“…Genome-wide association studies (GWAS) have revealed the polygenic nature of treatment-resistant schizophrenia TRS. Gene expression imputation allowed the…”
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Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort
Published in Psychiatry research (01-07-2023)“…•Cannabis use disorder polygenic risk score is linked to current cannabis use.•Cannabis initiation polygenic risk score is associated with psychotic…”
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Polygenic risk scores mediating functioning outcomes through cognitive and clinical features in youth at family risk and controls
Published in European neuropsychopharmacology (01-04-2024)“…Schizophrenia and bipolar disorder exhibit substantial clinical overlap, particularly in individuals at familial high risk, who frequently present…”
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The polygenic basis of relapse after a first episode of schizophrenia
Published in European neuropsychopharmacology (01-10-2023)“…•The polygenic risk score for educational attainment (PRS-EA), rather than psychopathological PRS (schizophrenia or bipolar disorder), was associated with…”
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Epigenetic clocks in relapse after a first episode of schizophrenia
Published in NPJ schizophrenia (22-07-2022)“…The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with…”
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