Search Results - "Prohaska, Joseph"

Role of copper transporters in copper homeostasis by Prohaska, Joseph R

“…Copper is a redox active metal that is essential for biological function. Copper is potentially toxic; thus, its homeostasis is carefully regulated through a…”
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Impact of copper deficiency in humans by Prohaska, Joseph R.

“…Humans consume about 1 mg of copper daily, an amount thought adequate for most needs. Genetic, environmental, or physiological alterations can impose a higher…”
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Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases) by Prohaska, Joseph R.

“…Copper is an essential trace element whose recommended intake is met by most North American diets. However, incidence of new cases of secondary copper…”
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Metabolic crossroads of iron and copper by Collins, James F, Prohaska, Joseph R, Knutson, Mitchell D

“…Interactions between the essential dietary metals, iron and copper, have been known for many years. This review highlights recent advances in iron‐copper…”
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Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cells in Vivo That Is Controlled at the Level of Protein Stability by Nose, Yasuhiro, Wood, L. Kent, Kim, Byung-Eun, Prohaska, Joseph R., Fry, Robert S., Spears, Jerry W., Thiele, Dennis J.

“…Copper is an essential trace element that functions in a diverse array of biochemical processes that include mitochondrial respiration, neurotransmitter…”
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Fetal and Neonatal Iron Deficiency Exacerbates Mild Thyroid Hormone Insufficiency Effects on Male Thyroid Hormone Levels and Brain Thyroid Hormone-Responsive Gene Expression by Bastian, Thomas W, Prohaska, Joseph R, Georgieff, Michael K, Anderson, Grant W

“…Fetal/neonatal iron (Fe) and iodine/TH deficiencies lead to similar brain developmental abnormalities and often coexist in developing countries. We recently…”
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Reflections of a cupromaniac by Prohaska, Joseph R

“…Joseph Prohaska reflects on a career in copper research…”
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Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency by Mostad, Elise J, Prohaska, Joseph R

“…Ceruloplasmin (Cp), a multicopper ferroxidase, is expressed as both a secreted (sCp) plasma enzyme from the liver and a membrane-bound…”
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Perinatal Iron and Copper Deficiencies Alter Neonatal Rat Circulating and Brain Thyroid Hormone Concentrations by Bastian, Thomas W, Prohaska, Joseph R, Georgieff, Michael K, Anderson, Grant W

“…Copper (Cu), iron (Fe), and iodine/thyroid hormone (TH) deficiencies lead to similar defects in late brain development, suggesting that these micronutrient…”
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Intracellular copper transport in mammals by Prohaska, Joseph R, Gybina, Anna A

“…Copper is an essential cofactor for approximately a dozen cuproenzymes in which copper is bound to specific amino acid residues in an active site. However,…”
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Essential Role for Mammalian Copper Transporter Ctr1 in Copper Homeostasis and Embryonic Development by Lee, Jaekwon, Prohaska, Joseph R., Thiele, Dennis J.

“…The trace metal copper (Cu) plays an essential role in biology as a cofactor for many enzymes that include Cu, Zn superoxide dismutase, cytochrome oxidase,…”
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Erythrocyte copper chaperone for superoxide dismutase is increased following marginal copper deficiency in adult and postweanling mice by Lassi, Katie C, Prohaska, Joseph R

“…A sensitive and reliable biomarker has yet to be identified for marginal copper deficiency in humans. The need for such a biomarker is critical, because…”
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Copper deficiency has minimal impact on ferroportin expression or function by Prohaska, Joseph R., Broderius, Margaret

“…Interactions between copper and iron homeostasis have been known since the nineteenth century when anemia in humans was first described due to copper…”
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ATP7A Gene Addition to the Choroid Plexus Results in Long-term Rescue of the Lethal Copper Transport Defect in a Menkes Disease Mouse Model by Donsante, Anthony, Yi, Ling, Zerfas, Patricia M, Brinster, Lauren R, Sullivan, Patricia, Goldstein, David S, Prohaska, Joseph, Centeno, Jose A, Rushing, Elisabeth, Kaler, Stephen G

“…Menkes disease is a lethal infantile neurodegenerative disorder of copper metabolism caused by mutations in a P-type ATPase, ATP7A. Currently available…”
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Fetal and Neonatal Iron Deficiency Reduces Thyroid Hormone-Responsive Gene mRNA Levels in the Neonatal Rat Hippocampus and Cerebral Cortex by Bastian, Thomas W, Anderson, Jeremy A, Fretham, Stephanie J, Prohaska, Joseph R, Georgieff, Michael K, Anderson, Grant W

“…Copper (Cu), iron (Fe), and thyroid hormone (TH) deficiencies produce similar defects in late brain development including hypomyelination of axons and impaired…”
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Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein by Wang, Yanfang, Zhu, Sha, Hodgkinson, Victoria, Prohaska, Joseph R, Weisman, Gary A, Gitlin, Jonathan D, Petris, Michael J

“…The essential requirement for copper in early development is dramatically illustrated by Menkes disease, a fatal neurodegenerative disorder of early childhood…”
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Levels of plasma ceruloplasmin protein are markedly lower following dietary copper deficiency in rodents by Broderius, Margaret, Mostad, Elise, Wendroth, Krista, Prohaska, Joseph R.

“…Ceruloplasmin (Cp) is a multicopper oxidase and the most abundant copper binding protein in vertebrate plasma. Loss of function mutations in humans or…”
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Essential Role for Atox1 in the Copper-Mediated Intracellular Trafficking of the Menkes ATPase by Hamza, Iqbal, Prohaska, Joseph, Gitlin, Jonathan D.

“…The metallochaperone Atox1 directly interacts with the copper-transporting ATPases and plays a critical role in perinatal copper homeostasis. To determine the…”
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Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice by West, Elizabeth C, Prohaska, Joseph R

“…Discovery of a sensitive blood biochemical marker of copper status would be valuable for assessing marginal copper intakes. Rodent models were used to…”
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Interactions of peptide amidation and copper: Novel biomarkers and mechanisms of neural dysfunction by Bousquet-Moore, Danielle, Prohaska, Joseph R, Nillni, Eduardo A, Czyzyk, Traci, Wetsel, William C, Mains, Richard E, Eipper, Betty A

“…Abstract Mammalian genomes encode only a small number of cuproenzymes. The many genes involved in coordinating copper uptake, distribution, storage and efflux…”
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